Results 251 to 260 of about 52,203 (302)

Feedback optimization of fed‐batch fermentation

Biotechnology and Bioengineering, 1987
AbstractThe problem of feedback optimization of the feed rate for fed‐batch fermentation processes is formulated in the framework of singular control theory and switching hypersurfaces. Using four differential balance equations that describe a general class of fedbatch processes and a general objective function to be minimized, it is shown that under ...
J M, Modak, H C, Lim
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Calorimetric control of fed‐batch fermentations

Biotechnology and Bioengineering, 1990
AbstractMeasurements of the heat produced by Saccharomyces cerevisiae CBS 426 were used in conjunction with elemental and enthalpic balances to control fed‐batch fermentations. A proportional control using the ratio of carbon dioxide evolution rate to heat production resulted in high biomass yields and minimal ethanol production.
T W, Randolph, I W, Marison, D E, Martens, U, von Stockar   +3 more
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Industrial Fed-Batch Fermentation Monitoring

IFAC Proceedings Volumes, 1997
Abstract A multivariate statistical model is developed and used for fault diagnosis of an industrial fed-batch fermentation process. Process faults may be detected on-line using existing measurements. In the applied approach the modelling is entirely data driven. Several data sets (25) are used to develop a model for cultivation behaviour. This model
Lars Gregersen, Sten Bay Jørgensen, Maria Yolanda Andersen   +2 more
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Supervision of fed-batch fermentations

Chemical Engineering Journal, 1999
Process faults may be detected on-line using existing measurements based upon modelling that is entirely data driven. A multivariate statistical model is developed and used for fault diagnosis of an industrial fed-batch fermentation process. Data from several (25) batches are used to develop a model for cultivation behaviour.
Lars Gregersen, Sten Bay Jørgensen
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Reachability of nonlinear fed‐batch fermentation processes

International Journal of Robust and Nonlinear Control, 2002
AbstractThe reachability of a simple nonlinear fed‐batch fermentation process model is investigated in this paper. It is shown that the known difficulties of controlling such processes are primarily caused by the fact that the rank of the reachability distribution is always less than the number of state variables.Furthermore, a co‐ordinates ...
Szederkényi, G., Kovács, M., Hangos, K. M.   +2 more
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Adaptive Optimal Control of Fed-Batch Alcoholic Fermentation

Applied Biochemistry and Biotechnology, 1998
An adaptive control scheme is developed for the optimization of a fed-batch ethanol production process. The fermentation process is modeled by an hybrid neural model combining mass balance equations and neural networks, used to represent the kinetic rates.
T L, Alves, A C, Costa, A W, Henriques, E L, Lima   +3 more
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Extended cyclic fed-batch tylosin fermentations

Biotechnology Letters, 1987
Biosynthesis of the macrolide antibiotic tylosin was studied in fed-batch fermentations. When glucose and sodium glutamate were fed to the fermentation in a cyclic square wave fashion with a period of 24 hours, it was possible to maintain high initial rates of tylosin biosynthesis for up to 240 hours before the synthetic rate decreased. By adding basic
P. P. Gray, K. Vu-Trong
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Fed-batch fermentation for ergosterol production

Process Biochemistry, 2003
Abstract The relationship between the fermentation parameters pH, DO and the concentrations of glucose, biomass and the ergosterol content of Saccharomyces cerevisiae in different fed-batch methods are discussed. Different fed-batch methods including constant feed rate fed-batch, constant glucose concentration fed-batch, exponential fed-batch, DO ...
Hua Gao, Tianwei Tan
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Robust operation of fed batch fermenters

Bioprocess Engineering, 1998
Optimisation of fed batch fermenters can substantially increase the profitability of these processes. Optimal control of a fed batch fermenter is usually based on a nominal process model. Parameter uncertainties are not taken into account. Simulation studies show that results obtained with fixed nominal model parameters can be quite sensitive to the ...
C. Kuhlmann, I. D. L. Bogle, Z. S. Chalabi   +2 more
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Ammonium controlled fed-batch fermentation for amylase production

Journal of Fermentation and Bioengineering, 1989
Abstract Batch and ammonium controlled fed-batch fermentations were compared for the production of amylase by Bacillus amyloliquefaciens . In shake flask culture, maximum amylase production was obtained when the concentration of ammonium was 20–30 mM. In a 15 l batch fermentation, maximum amylase production occurred at an ammonium concentration of
Manoj M. Kole, Donald F. Gerson
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