Antigenic and biological diversity of feline coronaviruses: feline infectious peritonitis and feline enteritis virus [PDF]
Antigenically related feline coronaviruses cause two distinct disease manifestations in infected cats. The diseases are feline infectious peritonitis (FIP), in which the virus is widely disseminated, and feline enteric coronavirus (FECV), a mild disease in which the virus is usually limited to the villi.
Tupper, G. T. +3 more
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Mutation in Spike Protein Cleavage Site and Pathogenesis of Feline Coronavirus
Feline coronaviruses (FCoV) exist as 2 biotypes: feline enteric coronavirus (FECV) and feline infectious peritonitis virus (FIPV). FECV causes subclinical infections; FIPV causes feline infectious peritonitis (FIP), a systemic and fatal disease.
Beth N. Licitra +6 more
doaj +1 more source
Feline Lectin Activity Is Critical for the Cellular Entry of Feline Infectious Peritonitis Virus [PDF]
ABSTRACTFeline infectious peritonitis is a lethal disease of felids caused by systemic infection with a feline coronavirus. Here, we report identification and analysis of the feline homologue to the human lectin DC-SIGN and show that it is a coreceptor for virulent strains of serotype 1 and serotype 2 feline coronaviruses.
Andrew D, Regan +2 more
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Enteritis due to Feline Infectious Peritonitis Virus
臨床・病理・血清学的にネコ伝染性腹膜炎(FIP)と診断され死亡したネコ4例および仔ネコの実験接種例14例について, 腸病変とウイルス抗原あるいはウイルス粒子の所在を検索した. 自然例2例および実験例12例が下痢を発した. 多くの病例の小腸・大腸粘膜は水腫性に肥厚し, 腸内容は水様~粘液状であった. 自然例3例および実験例12例の小腸・大腸病変は粘膜上皮の変性・剥離・増生を特徴とする比較的表在性の変化で, 固有層には浮腫, 少数の好中球お上び単核細胞浸潤がみられ, 隣接上皮細胞相互の癒合もしばしばみとめられた. しかし, 他の自然例1例および実験死亡例2例では, 小腸・大腸ともに炎症病変は激しく粘膜深部に及んでいた.
HAYASHI, Toshiharu +3 more
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Successful in vitro propagation of feline coronavirus from clinically diagnosed feline infectious peritonitis cases using Vero cells: A potential model for future research. [PDF]
Abstract Background Feline coronavirus (FCoV) causes inapparent to progressive fatal feline infectious peritonitis (FIP) in domestic and wild cats, which affects multiple‐organ systems. Methods We investigated three clinically sick cats using different laboratory and molecular tests to diagnose and confirm FCoV and propagate the virus in Vero cell ...
Rana EA +5 more
europepmc +2 more sources
Host Gene Expression of Macrophages in Response to Feline Coronavirus Infection
Feline coronavirus is a highly contagious virus potentially resulting in feline infectious peritonitis (FIP), while the pathogenesis of FIP remains not well understood, particularly in the events leading to the disease.
Yvonne Drechsler +4 more
doaj +1 more source
Coronaviruses are widespread in mammals and birds, causing mostly digestive and respiratory problems. In cats, feline coronaviruses undergo mutations while replicating, giving rise to the fatal coronavirus causing the feline infectious peritonitis (FIP ...
Ivona Popovici +3 more
doaj +1 more source
Application of versatile reverse genetics system for feline coronavirus
Feline infectious peritonitis (FIP) is a fatal disease caused by feline coronavirus (FCoV). Although multiple gene mutations in FCoV likely account for FIP pathogenesis, molecular studies for FCoV have been limited due to the lack of a suitable reverse ...
Izumi Kida +5 more
doaj +1 more source
Feline Infectious Peritonitis (FIP) Virus
Summary The highest susceptibility for infection with FIP virus (6th passage level) by the intracerebral route was observed in mice between 1 and 4 days of age, as judged from the intensity and extent of immunofluorescence in sections through the brains, spinal cord and retina; other organs were consistently negative.
Horzinek, M.C. +3 more
openaire +6 more sources
The Ultrastructure of Feline Infectious Peritonitis Virus in Feline Embryonic Lung Cells
The ultrastructure of feline infectious peritonitis virus in cultured feline embryonic lung cells is reported. Feline embryonic lung cells were infected with feline infectious peritonitis virus and studied by transmission electron microscopy. The virus was not apparent in the cultured cells until 24 h after infection when it occurred in the endoplasmic
J E, Beesley, L M, Hitchcock
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