Results 21 to 30 of about 87,565 (266)
High and Hyper: Fentanyl Induces Psychomotor Side-Effects in Healthy Pigs
Animals, 2023 Analgesic effects of fentanyl have been investigated using behavior. The behavioral effects of fentanyl and possible serotonergic influence are largely unknown.
Nora Digranes +2 more
doaj +1 more source
Higher doses of naloxone are needed in the synthetic opioid era
Substance Abuse Treatment, Prevention, and Policy, 2019 There has been a dramatic increase of deaths due to illicit fentanyl. We examined the pharmacology of fentanyl and reviewed data on the number of repeat doses of naloxone used to treat fentanyl overdoses.
Ronald B. Moss, Dennis J. Carlo
doaj +1 more source
Investigation of monoclonal antibody CSX-1004 for fentanyl overdose
Nature Communications, 2023 The opioid crisis in the United States is primarily driven by the highly potent synthetic opioid fentanyl leading to >70,000 overdose deaths annually; thus, new therapies for fentanyl overdose are urgently needed. Here, we present the first clinic-ready,
Paul T. Bremer +3 more
doaj +1 more source
Ain Shams Journal of Anesthesiology, 2020 Background Intravenous lidocaine has been shown to be an analgesic and anti-inflammatory medication with modulation of excessive inflammatory response.
Mostafa K. Abdellatif, Tamer H. Ibrahim
doaj +1 more source
Systemic Administration of Tempol Attenuates the Cardiorespiratory Depressant Effects of Fentanyl
Frontiers in Pharmacology, 2021 Fentanyl is a high-potency opioid receptor agonist that elicits profound analgesia and suppression of breathing in humans and animals. To date, there is limited evidence as to whether changes in oxidant stress are important factors in any of the actions ...
Santhosh Baby +9 more
doaj +1 more source
Intravenous fentanyl self-administration in male and female C57BL/6J and DBA/2J mice
Scientific Reports, 2023 The genetic mechanisms underlying fentanyl addiction, a highly heritable disease, are unknown. Identifying these mechanisms will lead to better risk assessment, early diagnosis, and improved intervention.
Michael Leonardo +4 more
doaj +1 more source
BMC Global and Public HealthBackground In the USA, many states, including Colorado, have increased criminal penalties for illicit opioid possession, which may alter overdose risk.
Katherine LeMasters +10 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Recent advances in diagnostics have accelerated the development of miniaturized wearable technologies for the continuous monitoring of diseases. This paradigm is shifting healthcare away from invasive, centralized blood tests toward decentralized monitoring, using alternative body biofluids.
Lanka Tata Rao +2 more
wiley +1 more source
Advanced Science, EarlyView.A new tissue sampling device using an acupuncture needle with bio‐compatible extraction sorbents in the recessed section is developed. The coating material using self‐wettable particles doesn't require solvent activation after sterilization. This device is applied for the anti‐cancer drug concentration monitoring during the in vivo lung perfusion ...
Runshan Will Jiang +9 more
wiley +1 more source
Fentanyl demand and seeking in female rats: Role of the orexin system and estrous cycle
Addiction NeuroscienceThe orexin system plays a major role in drug reward. Orexin-1 receptor (OxR1) blockade reduces fentanyl demand in males. However, there are a number of sex differences in the orexin system, and it is unclear how OxR1 antagonism would decrease fentanyl ...
David De Sa Nogueira +6 more
doaj +1 more source