Results 61 to 70 of about 188,238 (387)
Journal of Neuroscience, 2020 We recently developed a rat model of relapse to drug seeking after food choice-induced voluntary abstinence. Here, we used this model to study the role of the orbitofrontal cortex (OFC) and its afferent projections in relapse to fentanyl seeking.
D. Reiner +7 more
semanticscholar +1 more source
Exploring the baseline knowledge and experience of healthcare professionals in the United Kingdom on Novel Psychoactive Substances [PDF]
, 2020 Submitted 28 january 2020. Reviwers' comments received 11 February 2020. Accepted 26 February 2020. Published 2 March 2020.Objective: This survey aimed to explore knowledge and experience on novel psychoactive substances (NPS) of healthcare professionals
Bancroft, Angus +9 more
core +2 more sources
Effects of chronic fentanyl administration on behavioral characteristics of mice
Neuropsychopharmacology Reports, 2019 Background Fentanyl, a synthetic opioid categorized as a narcotic analgesic, has a 100‐ to 200‐fold stronger effect than most opioids, such as morphine. Fatal accidents due to chronic use and abuse of fentanyl are a worldwide social problem.
Kazuki Fujii +3 more
doaj +1 more source
Higher doses of naloxone are needed in the synthetic opioid era
Substance Abuse Treatment, Prevention, and Policy, 2019 There has been a dramatic increase of deaths due to illicit fentanyl. We examined the pharmacology of fentanyl and reviewed data on the number of repeat doses of naloxone used to treat fentanyl overdoses.
Ronald B. Moss, Dennis J. Carlo
doaj +1 more source
Intravenous fentanyl self-administration in male and female C57BL/6J and DBA/2J mice
Scientific Reports, 2023 The genetic mechanisms underlying fentanyl addiction, a highly heritable disease, are unknown. Identifying these mechanisms will lead to better risk assessment, early diagnosis, and improved intervention.
Michael Leonardo +4 more
doaj +1 more source
MMWR. Morbidity and mortality weekly report, 2020 Approximately two thirds of the 70,237 U.S. drug overdose deaths reported in 2017 involved opioids (1). Since 2013, opioid-involved overdose deaths involving illicitly manufactured fentanyl has sharply increased (1,2).
J. O'Donnell +4 more
semanticscholar +1 more source
Harm Reduction Journal, 2020 Background The opioid epidemic has caused an increase in overdose deaths which can be attributed to fentanyl combined with various illicit substances. Drug checking programs have been started by many harm reduction groups to provide tools for users to ...
Tracy-Lynn E. Lockwood +2 more
semanticscholar +1 more source
Abuse potential of fentanyl and fentanyl analogues
BioImpactsIntroduction: In this perspective review, we evaluated the clinical management of fatal fentanyl overdose in several routes of administration, concentrating on both legally prescribed and illegally produced formulations. Methods: A literature search was conducted on Web of Science, PubMed, and Google Scholar databases, using the following keywords ...
Anusha Thumma +5 more
openaire +3 more sources
Computational and Structural Biotechnology Journal, 2022 Fentanyl and its analogs are selective agonists of the µ-opioid receptor (MOR). Among novel synthetic opioids (NSOs), they dominate the recreational drug market and are the main culprits for the opioid crisis, which has been exacerbated by the COVID-19 ...
Bing Xie, Alexander Goldberg, Lei Shi
doaj
Journal of Pharmacology and Experimental Therapeutics, 2019 In December 2018, the Centers for Disease Control declared fentanyl the deadliest drug in America. Opioid overdose is the single greatest cause of death in the United States adult population (ages 18–50), and fentanyl and its analogs [fentanyl/fentanyl ...
Randy Torralva, A. Janowsky
semanticscholar +1 more source