Results 271 to 280 of about 775,242 (294)

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Controlling Off-Odors in Plant Proteins Using Sequential Fermentation. [PDF]

Foods
Kaur M, Gray C, Barringer S.
europepmc   +1 more source

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression

Advanced Science, EarlyView.
This study identifies elevated taurocholic acid (TCA) in Major Depressive Disorder patients. Gut microbiome‐associated TCA impairs hippocampal neurogenesis, triggers microglia activation, and elicits depression‐like behavior in mice via the S1PR2. In patients, functional neuroimaging reveals that serum TCA levels correlate with altered functional ...
Xiaoying Cai, Taipeng Sun, Mengzhen Feng, Gang Chen, Junchi Zhou, Hong Zhuang, Dan Wang, Ying Chen, Zhen Cheng, Zhi Xu, Xiao Zheng, Xueli Zhang, Yonggui Yuan   +12 more
wiley   +1 more source

Induced Phase Separation and Recovery of 2,3-Butanediol from Fermentation Broth. [PDF]

ACS Omega
Stoklosa RJ, Latona RJ.
europepmc   +1 more source

CellPolaris: Transfer Learning for Gene Regulatory Network Construction to Guide Cell State Transitions

Advanced Science, EarlyView.
CellPolaris decodes how transcription factors guide cell fate by building gene regulatory networks from transcriptomic data using transfer learning. It generates tissue‐ and cell‐type‐specific networks, identifies master regulators in cell state transitions, and simulates TF perturbations in developmental processes.
Guihai Feng, Xin Qin, Jiahao Zhang, Wuliang Huang, Yiyang Zhang, Wentao Cui, Yao Chen, Shirui Li, Wenhao Liu, Yao Tian, Yana Liu, Jingxi Dong, Ping Xu, Zhenpeng Man, Guole Liu, Zhongming Liang, Xinlong Jiang, Xiaodong Yang, Pengfei Wang, Ge Yang, Hongmei Wang, Xuezhi Wang, Ming‐Han Tong, Yuanchun Zhou, Shihua Zhang, Yiqiang Chen, Yong Wang, Xin Li   +27 more
wiley   +1 more source

Exploring the changes in anticoagulant active ingredients before and after bovine bile fermentation of the traditional Chinese medicine Yaomu <i>via</i> an aggregation-induced emission fluorescence sensor. [PDF]

RSC Adv
Qin Q, Zhang J, Feng G, Liao Y, Chen Y, Han C, Lei Y, Ma K, Li W, Jin Y, Wang J, Wang P, Wang B, Yu XA.   +13 more
europepmc   +1 more source

Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins

Advanced Science, EarlyView.
As newly emerged optogenetic tools, potassium channelrhodopsins (KCRs) can drift from inhibition to activation during illumination as K⁺ selectivity declines. It is shown that both the absolute K⁺/Na⁺ permeability ratio and its stability over time govern this drift, identify KCR1‐C29D as a reliably inhibitory variant, and outline design principles for ...
Xiao Duan, Chong Zhang, Stanislav Ott, Zhiyi Zhang, Christiane Ruse, Sven Dannhäuser, Robert Jacobi, Nadine Ehmann, Divya Sachidanandan, Georg Nagel, Manfred Heckmann, Robert J. Kittel, Alexander Gottschalk, Adam Claridge‐Chang, Shiqiang Gao   +14 more
wiley   +1 more source

<i>Lachnoclostridium</i>-mediated fermentation of <i>Konjac glucomannan</i>: short chain fatty acids production and inhibitory xanthine oxidase activity. [PDF]

Front Nutr
Deng J, Liang Y, Zhang Z, Yang Z, Bao Y, Nong Y, Wang H, Zhao C, Mai S, Tan C, Pan Y, Feng C, Li M, Luo W.   +13 more
europepmc   +1 more source

Edible Pneumatic Battery for Sustained and Repeated Robot Actuation

Advanced Science, EarlyView.
This work presents an edible energy source and valve system to power soft, pneumatically driven edible robots. A chemical reaction between sodium bicarbonate and citric acid generates carbon dioxide gas, and a pressure‐triggered edible valve enables self‐repetitive motion of the edible actuator.
Bokeon Kwak, Shuhang Zhang, Alexander Keller, Qiukai Qi, Jonathan Rossiter, Dario Floreano   +5 more
wiley   +1 more source

Fruit Rind Peel as Promising Support Materials for Immobilizing Yeast Cells and Application in Repeated-Batch Cider and Wine Fermentation with Improved Aromatic Compound Profiles. [PDF]

J Microbiol Biotechnol
Intasit R, Iadcharoen A, Cheirsilp B.
europepmc   +1 more source