Pharmacologic Inhibition of Erythrocyte Ferroportin Expression Exacerbates Plasmodium Infection [PDF]
MicroorganismsPlasmodium parasites rely on host iron for survival and replication, making host iron availability a critical determinant of malaria pathogenesis. Central to iron homeostasis is the hepcidin–ferroportin regulatory axis, where hepcidin suppresses iron ...
Sareh Zeydabadinejad +6 more
doaj +2 more sources
Hepcidin, ferroportin, and hemoglobin as predictors of iron deficiency anemia risk and perinatal outcomes in twin pregnancy [PDF]
Frontiers in MedicineObjectiveThis study investigated iron-deficiency anemia (IDA), third-trimester hepcidin and ferroportin levels, and perinatal outcomes in twin pregnancies.Study designPregnant women with twin gestations (n = 195) were enrolled and classified into an IDA ...
Yanling Zhong +9 more
doaj +2 more sources
Reduced sensitivity of the ferroportin Q248H mutant to physiological concentrations of hepcidin
Haematologica, 2013 Ferroportin Q248H mutation has an allele frequency of 2.2–13.4% in African populations and is associated with a mild tendency to increased serum ferritin in the general population. Some investigators have reported that ferroportin Q248H is degraded after
Sergei Nekhai +9 more
doaj +3 more sources
The Role of Copper in the Regulation of Ferroportin Expression in Macrophages [PDF]
Cells, 2021 The critical function of ferroportin (Fpn) in maintaining iron homeostasis requires complex and multilevel control of its expression. Besides iron-dependent cellular and systemic control of Fpn expression, other metals also seem to be involved in ...
Aneta Jończy +6 more
doaj +2 more sources
Structural basis of ion transport and inhibition in ferroportin
Nature Communications, 2020 Ferroportin is an iron exporter essential for releasing cellular iron into circulation and is inhibited by a peptide hormone, hepcidin. Here authors present cryo-EM structures of the ferroportin from the primate Philippine tarsier (TsFpn) with and ...
Yaping Pan, Shuai Gao, Jiemin Shen
exaly +2 more sources
Polychlorinated Biphenyl 138 Induces Toxicant-Associated Steatohepatitis via Hepatic Iron Overload and Adipose Inflammation [PDF]
ToxicsToxicant-associated steatohepatitis (TASH) is caused by environmental toxicants rather than metabolic factors; however, its pathogenic mechanisms remain poorly understood.
Hyeon Jeong Hwang +9 more
doaj +2 more sources
Safety and pharmacodynamics of the ferroportin inhibitor vamifeport in patients with non-transfusion-dependent β-thalassemia: results from a randomized phase 2a study. [PDF]
Orphanet J Rare DisKattamis A +8 more
europepmc +4 more sources
Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt [PDF]
Nature Communications, 2016 Ja Hyun Koo +2 more
exaly +2 more sources
UBA6 and NDFIP1 regulate the degradation of ferroportin
Haematologica, 2021 Hepcidin regulates iron homeostasis by controlling the level of ferroportin, the only membrane channel that facilitates export of iron from within cells.
Lisa Traeger +10 more
doaj +1 more source
Hepatology Communications, 2021 Hepcidin is a liver‐derived peptide hormone that limits iron egress from tissues to the bloodstream. It operates by binding to the iron exporter ferroportin, which blocks iron transport and tags ferroportin for degradation.
Angeliki Katsarou +3 more
doaj +1 more source