Results 11 to 20 of about 17,727 (258)
Cellular catabolism of the iron-regulatory peptide hormone hepcidin. [PDF]
PLoS ONE, 2013 Hepcidin, a 25-amino acid peptide hormone, is the principal regulator of plasma iron concentrations. Hepcidin binding to its receptor, the iron exporter ferroportin, induces ferroportin internalization and degradation, thus blocking iron efflux from ...
Gloria Cuevas Preza +3 more
doaj +8 more sources
Hepcidin targets ferroportin for degradation in hepatocytes
Haematologica, 2010 Hepcidin, a circulating regulatory hormone peptide produced by hepatocytes, functions as the master regulator of cellular iron export by controlling the amount of ferroportin, an iron exporter present on the basolateral surface of intestinal enterocytes ...
Guillemette Ramey +5 more
doaj +4 more sources
Lactoferrin Efficiently Counteracts the Inflammation-Induced Changes of the Iron Homeostasis System in Macrophages [PDF]
Frontiers in Immunology, 2017 Human lactoferrin (hLf), an 80-kDa multifunctional iron-binding cationic glycoprotein, is constitutively secreted by exocrine glands and by neutrophils during inflammation. hLf is recognized as a key element in the host immune defense system.
Antimo Cutone +7 more
doaj +4 more sources
Blood Cells, Molecules, and Diseases, 2014 A new inherited disorder of iron metabolism, hereafter called "the ferroportin disease," is increasingly recognized worldwide. The disorder is due to pathogenic mutations in the SLC40A1 gene encoding for a main iron export protein in mammals, ferroportin1/IREG1/MTP1, and it was originally identified as an autosomal-dominant form of iron overload not ...
Antonello Pietrangelo
+7 more sources
Hepcidin-ferroportin axis in health and disease
, 2019 Hepcidin is central to regulation of iron metabolism. Its effect on a cellular level involves binding ferroportin, the main iron export protein, resulting in its internalization and degradation and leading to iron sequestration within ferroportin-expressing cells.
Yelena Ginzburg
openalex +5 more sources
Insights Into Macrophage Ferroptosis: Implications for Atherosclerosis. [PDF]
Cell ProlifMacrophage ferroptosis drives atherosclerosis by enhancing oxidative stress and inflammation, accelerating plaque progression and instability. Targeting macrophage ferroptosis presents a promising therapeutic strategy for atherosclerosis treatment.
Chen X, Liu X, Zeng C.
europepmc +2 more sources
Mechanism of Ca2+ transport by ferroportin
eLife, 2023 Abstract Ferroportin (Fpn) is a transporter that releases Fe 2+ from cells and is important for iron homeostasis in circulation. Export of Fe 2+ by Fpn is coupled to import of H + to maintain charge balance ...
Jiemin Shen +3 more
openalex +5 more sources
Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis [PDF]
International Journal of Molecular Sciences, 2021 Despite its abundance in the environment, iron is poorly bioavailable and subject to strict conservation and internal recycling by most organisms. In vertebrates, the stability of iron concentration in plasma and extracellular fluid, and the total body iron content are maintained by the interaction of the iron-regulatory peptide hormone hepcidin with ...
Elizabeta Nemeth, Tomas Ganz
openalex +6 more sources
A disease-causing mutation K240E disrupts ferroportin trafficking by SUMO (ferroportin SUMOylation)
Biochemistry and Biophysics Reports, 2021 Ferroportin (Fpn/IREG1/MTP1) is the only known transporter mediating iron efflux from epithelial cells and macrophages, and thus regulates how much iron is released into the circulation. Consequently, Fpn mutations are associated with haemochromatosis. Fpn itself is post-translationally regulated by hepcidin (Hepc) which induces its redistribution and ...
Henry K. Bayele, Surjit Kaila S. Srai
openaire +4 more sources
Evidence for the multimeric structure of ferroportin [PDF]
Blood, 2006 Abstract Ferroportin (Fpn) (IREG1, SLC40A1, MTP1) is an iron transporter, and mutations in Fpn result in a genetically dominant form of iron overload disease. Previously, we demonstrated that Fpn is a multimer and that mutations in Fpn are dominant negative.
Ivana De Domenico +3 more
openalex +5 more sources