Results 21 to 30 of about 17,727 (258)
Hepcidin-Induced Endocytosis of Ferroportin Is Dependent on Ferroportin Ubiquitination [PDF]
Cell Metabolism, 2012 Ferroportin exports iron into plasma from absorptive enterocytes, erythrophagocytosing macrophages, and hepatic stores. The hormone hepcidin controls cellular iron export and plasma iron concentrations by binding to ferroportin and causing its internalization and degradation. We explored the mechanism of hepcidin-induced endocytosis of ferroportin, the
Qiao, Bo +6 more
openaire +2 more sources
Human macrophage ferroportin biology and the basis for the ferroportin disease [PDF]
Hepatology, 2017 Ferroportin (FPN1) is the sole iron exporter in mammals, but its cell‐specific function and regulation are still elusive. This study examined FPN1 expression in human macrophages, the cells that are primarily responsible on a daily basis for plasma iron turnover and are central in the pathogenesis of ferroportin disease (FD), the disease attributed to ...
M. Sabelli +6 more
openaire +2 more sources
Flatiron Mice and Ferroportin Disease [PDF]
Nutrition Reviews, 2007 Flatiron mice provide the first genetic model that fully recapitulates the iron-loading disorder ferroportin disease. Unlike the other known genetic causes of hemochromatosis, missense mutations in the ferroportin gene are autosomal dominant. These new findings show that ferroportin disease results from dominant negative effects rather than haplo ...
Erin E, Johnson +1 more
openaire +2 more sources
Leishmania-mediated inhibition of iron export promotes parasite replication in macrophages. [PDF]
PLoS Pathogens, 2014 Leishmania parasites infect macrophages, cells that play an important role in organismal iron homeostasis. By expressing ferroportin, a membrane protein specialized in iron export, macrophages release iron stored intracellularly into the circulation ...
Rym Ben-Othman +5 more
doaj +1 more source
eLife, 2022 The iron hormone hepcidin is transcriptionally activated by iron or inflammation via distinct, partially overlapping pathways. We addressed how iron affects inflammatory hepcidin levels and the ensuing hypoferremic response. Dietary iron overload did not
Edouard Charlebois +8 more
doaj +1 more source
The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages [PDF]
Nature Communications, 2018 Oriana Marques +2 more
exaly +2 more sources
Modelling Systemic Iron Regulation during Dietary Iron Overload and Acute Inflammation: Role of Hepcidin-Independent Mechanisms. [PDF]
PLoS Computational Biology, 2017 Systemic iron levels must be maintained in physiological concentrations to prevent diseases associated with iron deficiency or iron overload. A key role in this process plays ferroportin, the only known mammalian transmembrane iron exporter, which ...
Mihaela Enculescu +6 more
doaj +1 more source
Cell Death Discovery, 2022 Compared to cancer cells, macrophages are inert to lipid peroxidation-triggered, iron-dependent cell death known as ferroptosis. Mechanisms underlying macrophage resistance towards ferroptosis are largely obscure.
Dmitry Namgaladze +2 more
doaj +1 more source
The effect of amino acid deprivation on the transfer of iron through Caco-2 cell monolayers [PDF]
, 2017 Funding Source Rural and Environmental Scientific and Analytical Services, the Scottish Government Acknowledgments We thank Dr Helen Hayes for her technical support during this project.
Cottin, Sarah +3 more
core +3 more sources
Journal of Biomedical Science, 2023 Background Apo- (iron free) and holo- (iron bound) transferrin (Tf) participate in precise regulation of brain iron uptake at endothelial cells of the blood–brain barrier.
Stephanie L. Baringer +4 more
doaj +1 more source