Combined use of x-ray fluorescence microscopy, phase contrast imaging for high resolution quantitative iron mapping in inflamed cells [PDF]
, 2017 X-ray fluorescence microscopy (XRFM) is a powerful technique to detect and localize elements in cells. To derive information useful for biology and medicine, it is essential not only to localize, but also to map quantitatively the element concentration ...
Berlutti, Francesca +16 more
core +2 more sources
Cellular and Molecular Gastroenterology and Hepatology, 2017 Background & Aims: Previous studies have suggested that iron absorption in suckling mammals is refractory to stimuli that normally would decrease absorption in adults.
David M. Frazer +5 more
doaj +1 more source
Ferroportin depletes iron needed for cell cycle progression in head and neck squamous cell carcinoma
Frontiers in Oncology, 2023 IntroductionFerroportin (FPN), the only identified eukaryotic iron efflux channel, plays an important role in iron homeostasis and is downregulated in many cancers.
Benjamin Ross Belvin +3 more
doaj +1 more source
Ferroportin and Erythroid Cells: An Update [PDF]
Advances in Hematology, 2010 In recent years there have been major advances in our knowledge of the regulation of iron metabolism that have had implications for understanding the pathophysiology of some human disorders like beta-thalassemia and other iron overload diseases.
Luciano Cianetti +2 more
openaire +3 more sources
Ironing out the details: Untangling dietary iron and genetic background in diabetes [PDF]
, 2018 The search for genetic risk factors in type-II diabetes has been hindered by a failure to consider dietary variables. Dietary nutrients impact metabolic disease risk and severity and are essential to maintaining metabolic health.
Lawson, Heather A, Miranda, Mario A
core +2 more sources
Lactoferrin. A natural glycoprotein involved in iron and inflammatory homeostasis [PDF]
, 2017 Human lactoferrin (hLf), an iron-binding multifunctional cationic glycoprotein secreted by exocrine glands and by neutrophils, is a key element of host defenses.
Cutone, Antimo +4 more
core +4 more sources
Hepcidin induces HIV-1 transcription inhibited by ferroportin
Retrovirology, 2010 Background Physiological regulation of cellular iron involves iron export by the membrane protein, ferroportin, the expression of which is induced by iron and negatively modulated by hepcidin.
Turner Willie +6 more
doaj +1 more source
Iron-tracking strategies: Chaperones capture iron in the cytosolic labile iron pool
Frontiers in Molecular Biosciences, 2023 Cells express hundreds of iron-dependent enzymes that rely on the iron cofactors heme, iron-sulfur clusters, and mono-or di-nuclear iron centers for activity.
Caroline C. Philpott +6 more
doaj +1 more source
Efficacy of lactoferrin oral administration in the treatment of anemia and anemia of inflammation in pregnant and non-pregnant women: an interventional study [PDF]
, 2018 The discovery of the ferroportin-hepcidin complex has led to a critical review on the treatment of anemia and anemia of inflammation (AI). Ferroportin, the only known mammalian iron exporter from cells to blood, is negatively regulated by hepcidin, a ...
Antimo Cutone +6 more
core +2 more sources
The dynamics of hepcidin‐ferroportin internalization and consequences of a novel ferroportin disease mutation [PDF]
American Journal of Hematology, 2017 AbstractThe hepcidin‐ferroportin axis underlies the pathophysiology of many iron‐associated disorders and is a key target for the development of therapeutics for treating iron‐associated disorders. The aims of this study were to investigate the dynamics of hepcidin‐mediated ferroportin internalization and the consequences of a novel disease‐causing ...
Daniel F. Wallace +5 more
openaire +3 more sources