Results 41 to 50 of about 17,727 (258)

Identification of Antibody and Small Molecule Antagonists of Ferroportin-Hepcidin Interaction

Frontiers in Pharmacology, 2017
The iron exporter ferroportin and its ligand, the hormone hepcidin, control fluxes of stored and recycled iron for use in a variety of essential biochemical processes. Inflammatory disorders and malignancies are often associated with high hepcidin levels,
Sandra L. Ross, Kaustav Biswas, James Rottman, Jennifer R. Allen, Jason Long, Les P. Miranda, Aaron Winters, Tara L. Arvedson   +7 more
doaj   +1 more source

Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin

Clinical and Translational Medicine, 2021
Background Ferroptosis is essential to regulate tumor growth and serves as a promising therapeutic target to lung cancer. Ubiquitin‐specific protease 35 (USP35) belongs to the deubiquitinases family that is associated with cell proliferation and mitosis.
Zheng Tang, Wanli Jiang, Ming Mao, Jinping Zhao, Jiakuan Chen, Nitao Cheng   +5 more
doaj   +1 more source

Ferrostatin-1 Ameliorates Liver Dysfunction via Reducing Iron in Thioacetamide-induced Acute Liver Injury in Mice

Frontiers in Pharmacology, 2022
Background and Aims: Hepatic iron overload always leads to oxidative stress, which has been found to be involved in the progression of liver disease. However, whether iron disorder is involved in acute liver disease and the further molecular mechanisms ...
Hui Jiang, Xinyu Zhang, Wanping Yang, Meiqi Li, Guohua Wang, Qianqian Luo   +5 more
doaj   +1 more source

Lipid raft-dependent endocytosis: a new route for hepcidin-mediated regulation of ferroportin in macrophages

Haematologica, 2010
Background Expression of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and is decreased by hepcidin. We previously showed that ferroportin is present in specific cell surface domains suggestive of lipid ...
Anne Auriac, Alexandra Willemetz, François Canonne-Hergaux   +2 more
doaj   +1 more source

Molecular Mechanism of Hepcidin-Mediated Ferroportin Internalization Requires Ferroportin Lysines, Not Tyrosines or JAK-STAT [PDF]

Cell Metabolism, 2012
Ferroportin is the primary means of cellular iron efflux and a key component of iron metabolism. Hepcidin regulates Fpn activity by inducing its internalization and degradation. The mechanism of internalization is reported to require JAK2 activation, phosphorylation of Fpn tyrosine residues 302 and 303, and initiation of transcription through STAT3 ...
Ross, Sandra L., Tran, Lynn, Winters, Aaron, Lee, Ki-Jeong, Plewa, Cherylene, Foltz, Ian, King, Chadwick, Miranda, Les P., Allen, Jennifer, Beckman, Holger, Cooke, Keegan S., Moody, Gordon, Sasu, Barbra J., Nemeth, Elizabeta, Ganz, Tomas, Molineux, Graham, Arvedson, Tara L.   +16 more
openaire   +2 more sources

Heme Oxygenase Induction Suppresses Hepatic Hepcidin and Rescues Ferroportin and Ferritin Expression in Obese Mice [PDF]

, 2017
Hepcidin, a phase II reactant secreted by hepatocytes, regulates cellular iron levels by increasing internalization of ferroportin-a transmembrane protein facilitating egress of cellular iron.
Arefiev, Yevgeniy, Chao, Robert, Chaudry, Hibba, Klug, Rebecca, Lakhani, Vishal Hari, Nawab, Athar, Nichols, Alexandra, Peterson, Stephen J., Puri, Nitin, Sacerdoti, David, Sharma, Dana, Sodhi, Komal, Srikathanan, Krithika   +12 more
core   +2 more sources

Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position −7007 of the FPN1 promoter

Haematologica, 2010
Background Macrophages of the reticuloendothelial system play a key role in recycling iron from hemoglobin of senescent or damaged erythrocytes. Heme oxygenase 1 degrades the heme moiety and releases inorganic iron that is stored in ferritin or exported ...
Samuele Marro, Deborah Chiabrando, Erika Messana, Jens Stolte, Emilia Turco, Emanuela Tolosano, Martina U. Muckenthaler   +6 more
doaj   +1 more source

Hepcidin and iron homeostasis during pregnancy. [PDF]

, 2014
Hepcidin is the master regulator of systemic iron bioavailability in humans. This review examines primary research articles that assessed hepcidin during pregnancy and postpartum and report its relationship to maternal and infant iron status and birth ...
Cadwell, Brooke, Day, Jessica, Koenig, Mary Dawn, Nemeth, Elizabeta, Tussing-Humphreys, Lisa   +4 more
core   +1 more source

Twenty Years of Ferroportin Disease: A Review or An Update of Published Clinical, Biochemical, Molecular, and Functional Features

Pharmaceuticals, 2019
Iron overloading disorders linked to mutations in ferroportin have diverse phenotypes in vivo, and the effects of mutations on ferroportin in vitro range from loss of function (LOF) to gain of function (GOF) with hepcidin resistance.
L. Tom Vlasveld, Roel Janssen, Edouard Bardou-Jacquet, Hanka Venselaar, Houda Hamdi-Roze, Hal Drakesmith, Dorine W. Swinkels   +6 more
doaj   +1 more source

Ferroportin: Lack of evidence for multimers

Blood Cells, Molecules, and Diseases, 2008
Ferroportin is a multi-transmembrane glycoprotein that mediates iron export from cells. Mutations in ferroportin are linked to type IV hemochromatosis, a dominantly inherited disorder of iron metabolism. Multimers of ferroportin, whose existence may relate to the dominant inheritance pattern of disease, have been detected in some studies but not others.
Schimanski, L, Drakesmith, H, Talbott, C, Horne, K, James, JR, Davis, S, Sweetland, E, Bastin, J, Cowley, D, Townsend, A   +9 more
openaire   +2 more sources