Results 51 to 60 of about 17,727 (258)

Hepcidin and Host Defense against Infectious Diseases. [PDF]

, 2015
Hepcidin is the master regulator of iron homeostasis in vertebrates. The synthesis of hepcidin is induced by systemic iron levels and by inflammatory stimuli.
Ganz, Tomas, Mehrad, Borna, Michels, Kathryn, Nemeth, Elizabeta   +3 more
core   +1 more source

Hepcidin and erythroferrone response to 3 weeks of exposure to normobaric hypoxia at rest in trained cyclists

Frontiers in Physiology, 2023
Purpose: The effectiveness of altitude training on haematological adaptations is largely dependent on iron metabolism. Hepcidin and erythroferrone (ERFE) are key iron-regulating hormones, yet their response to altitude training is poorly understood.
Kamila Płoszczyca, Miłosz Czuba, Małgorzata Chalimoniuk, Konrad Witek, Marcin Baranowski   +4 more
doaj   +1 more source

Placental iron utilisation in fetal growth restriction: alterations in mitochondrial haem synthesis and iron-sulphur cluster assembly pathways. [PDF]

J Physiol
Abstract figure legend Altered iron handling and mitochondrial pathways in FGR placentas. Placental tissue from FGR pregnancies showed increased expression of iron importers, transferrin and divalent metal transporter 1, and decreased expression of the iron exporter ferroportin, suggesting that the FGR placenta is retaining iron to meet its own ...
Botha VB, Murray HC, Acharya S, Pringle KG, Smith R, Fisher JJ.   +5 more
europepmc   +2 more sources

Long-term phlebotomy successfully alleviated hepatic iron accumulation in a ferroportin disease patient with a mutation in SLC40A1: a case report

BMC Gastroenterology, 2021
Background Hereditary hemochromatosis is a heterogenous group of inherited iron-overload conditions that is characterized by increased intestinal absorption and deposition in vital organs.
Sohji Nishina, Yasuyuki Tomiyama, Katsuya Ikuta, Yasuaki Tatsumi, Yasumichi Toki, Ayako Kato, Koichi Kato, Naoko Yoshioka, Kyo Sasaki, Yuichi Hara, Keisuke Hino   +10 more
doaj   +1 more source

The molecular basis of ferroportin-linked hemochromatosis [PDF]

Proceedings of the National Academy of Sciences, 2005
Mutations in the iron exporter ferroportin (Fpn) (IREG1, SLC40A1 , and MTP1) result in hemochromatosis type IV, a disorder with a dominant genetic pattern of inheritance and heterogeneous clinical presentation. Most patients develop iron loading of Kupffer cells with relatively low saturation
DE DOMENICO I, WARD DM, NEMETH E, VAUGHN MB, MUSCI, Giovanni, GANZ T, KAPLAN J.   +6 more
openaire   +3 more sources

Neuropilin-1 Controls Endothelial Homeostasis by Regulating Mitochondrial Function and Iron-Dependent Oxidative Stress. [PDF]

, 2018
The transmembrane protein neuropilin-1 (NRP1) promotes vascular endothelial growth factor (VEGF) and extracellular matrix signaling in endothelial cells (ECs).
Bosseboeuf, E, Chikh, A, De Winter, N, Dufton, N, Gestri, G, Issitt, T, Raimondi, C, Randi, AM, Senatore, V   +8 more
core   +3 more sources

TAM-ing the CIA—Tumor-Associated Macrophages and Their Potential Role in Unintended Side Effects of Therapeutics for Cancer-Induced Anemia

Frontiers in Oncology, 2021
Cancer-induced anemia (CIA) is a common consequence of neoplasia and has a multifactorial pathophysiology. The immune response and tumor treatment, both intended to primarily target malignant cells, also affect erythropoiesis in the bone marrow.
Stefan Weiler, Stefan Weiler, Manfred Nairz   +2 more
doaj   +1 more source

Isolation and thermal stabilization of mouse ferroportin [PDF]

FEBS Open Bio, 2020
Ferroportin (Fpn) is an essential mammalian iron transporter that is negatively regulated by the hormone hepcidin. Our current molecular understanding of Fpn‐mediated iron efflux and regulation is limited due to a lack of biochemical, biophysical and high‐resolution structural studies.
Chandrika N. Deshpande, Corbin R. Azucenas, Bo Qiao, Norimichi Nomura, Vicky Xin, Josep Font, So Iwata, Tomas Ganz, Elizabeta Nemeth, Bryan Mackenzie, Mika Jormakka   +10 more
openaire   +4 more sources

Ferroportin-related haemochromatosis associated with novel Y64H mutation of the SCL40A1 gene [PDF]

, 2014
In this paper we described the first Polish patient with ferroportin disease. Hereditary haemochromatosis (HH) is a condition associated with universal iron overload, and it is divided into four types, according to the Online Mendelian Inheritance in Man
Caleffi, Angela, Milkiewicz, Piotr, PIETRANGELO, Antonello, Raszeja Wyszomirska, Joanna   +3 more
core   +1 more source

An essential cell-autonomous role for hepcidin in cardiac iron homeostasis

eLife, 2016
Hepcidin is the master regulator of systemic iron homeostasis. Derived primarily from the liver, it inhibits the iron exporter ferroportin in the gut and spleen, the sites of iron absorption and recycling respectively.
Samira Lakhal-Littleton, Magda Wolna, Yu Jin Chung, Helen C Christian, Lisa C Heather, Marcella Brescia, Vicky Ball, Rebeca Diaz, Ana Santos, Daniel Biggs, Kieran Clarke, Benjamin Davies, Peter A Robbins   +12 more
doaj   +1 more source