Physiological implications of NTBI uptake by T lymphocytes [PDF]
, 2014 In iron overload disorders a significant fraction of the total iron circulates in the plasma as low molecular weight complexes not bound to transferrin, known as non-transferrin-bound iron (NTBI).
Arezes, J. +10 more
core +1 more source
HFE-Related Hemochromatosis May Be a Primary Kupffer Cell Disease
BiomedicinesIron overload can lead to increased deposition of iron and cause organ damage in the liver, the pancreas, the heart and the synovium. Iron overload disorders are due to either genetic or acquired abnormalities such as excess transfusions or chronic liver
Elias Kouroumalis +2 more
doaj +1 more source
Inherited Disorders of Iron Overload
Frontiers in Nutrition, 2018 Dietary iron absorption and systemic iron traffic are tightly controlled by hepcidin, a liver-derived peptide hormone. Hepcidin inhibits iron entry into plasma by binding to and inactivating the iron exporter ferroportin in target cells, such as duodenal
Kostas Pantopoulos, Kostas Pantopoulos
doaj +1 more source
The gut in iron homeostasis: role of HIF-2 under normal and pathological conditions. [PDF]
, 2013 International audienceAlthough earlier, seminal studies demonstrated that the gut per se has the intrinsic ability to regulate the rates of iron absorption, the spotlight in the past decade has been placed on the systemic regulation of iron homeostasis ...
Mastrogiannaki, Maria +2 more
core +4 more sources
High resolution preparation of monocyte-derived macrophages (MDM) protein fractions for clinical proteomics [PDF]
, 2009 Background: Macrophages are involved in a number of key physiological processes and complex responses such as inflammatory, immunological, infectious diseases and iron homeostasis.
Rita Polati +9 more
core +1 more source
Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mouse model of hereditary hemochromatosis [PDF]
, 2018 Osteoporosis is associated with chronic iron overload secondary to hereditary hemochromatosis (HH), but the causative mechanisms are incompletely understood.
Camacho, António +7 more
core +4 more sources
Borrowed alleles and convergence in serpentine adaptation [PDF]
, 2016 ACKNOWLEDGMENTS. We thank members of the L.Y. and K.B. laboratories for helpful discussions. This work was supported through the European Research Council Grant StG CA629F04E (to L.Y.); a Harvard University Milton Fund Award (to K.B.); Ruth L ...
Arnold, Brian J. +7 more
core +2 more sources
BiomoleculesAlzheimer’s disease (AD) is a prevalent neurodegenerative disorder characterized by cognitive decline and neuropathological hallmarks, including β-amyloid (Aβ) plaques, Tau tangles, synaptic dysfunction and neurodegeneration.
Susana Junceda +5 more
doaj +1 more source
S36 Ferroportin Is Expressed In Human Pulmonary Artery Smooth Muscle Cells: Implications For Pulmonary Arterial Hypertension [PDF]
, 2014 Latha Ramakrishnan +3 more
openalex +1 more source
Decreased ferroportin in hepatocytes promotes macrophages polarize towards an M2-like phenotype and liver fibrosis [PDF]
, 2021 Chengyuan Cai +6 more
openalex +1 more source