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Ferulic acid: Pharmacological and toxicological aspects
Food and Chemical Toxicology, 2014Ferulic acid (FA) belongs to the family of phenolic acids and is very abundant in fruits and vegetables. Over the past years, several studies have shown that FA acts as a potent antioxidant by scavenging free radicals and enhancing the cell stress response through the up-regulation of cytoprotective systems, e.g. heme oxygenase-1, heat shock protein 70,
Mancuso, Cesare, Santangelo, Rosaria
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Specificity of ferulic acid (feruloyl) esterases
Biochemical Society Transactions, 1998Specificity of ferulic acid (feruloyl) esterases G. Williamson’, C. B. Faulds and P. A. Kroon Biochemistry Department, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, U.K. 205 moyl esters (manifest as a K,,, of between lop6 Feruloyl esterases are a subclass of the carboxylic ester hydrolases (EC 3.1.1.1) which hydrolyse ...
G, Williamson, C B, Faulds, P A, Kroon
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Esterification of ferulic acid with polyols using a ferulic acid esterase from Aspergillus niger
Biochimica et Biophysica Acta (BBA) - General Subjects, 2006Commercially available enzyme preparations were screened for enzymes that have a high ability to catalyze direct ester-synthesis of ferulic acid with glycerol. Only a preparation, Pectinase PL "Amano" produced by Aspergillus niger, feruloylated glycerol under the experimental conditions.
Moriyasu, Tsuchiyama +4 more
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Antioxidant potential of ferulic acid
Free Radical Biology and Medicine, 1992Ferulic acid is a ubiquitous plant constituent that arises from the metabolism of phenylalanine and tyrosine. It occurs primarily in seeds and leaves both in its free form and covalently linked to lignin and other biopolymers. Due to its phenolic nucleus and an extended side chain conjugation, it readily forms a resonance stabilized phenoxy radical ...
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Antioxidative potential of ferulic acid phenoxyl radical
Phytochemistry, 2020The vast majority of previous studies dealing with antioxidant potency of (poly)phenols does not investigate the fate of phenoxyl radical obtained after single free radical scavenging. We investigated possible pathways of inactivation of ferulic acid phenoxyl radical (FAPR) using DFT method.
Amić, Ana +4 more
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Ferulic Acid and Alzheimer’s Disease: Promises and Pitfalls
Mini-Reviews in Medicinal Chemistry, 2015Oxidative stress plays an important role in both initiation and progression of neurodegenerative diseases, such as Alzheimer and Parkinson. Therefore, much attention has been paid to antioxidants for developing therapeutic strategies for the neurodegenerative diseases.
Nabavi Seyed Fazel +5 more
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Detoxification of ferulic acid by ectomycorrhizal fungi
Mycorrhiza, 2003The ectomycorrhizal fungi Laccaria amethystina and Lactarius deterrimus grown in liquid culture were used to study the fate of added ferulic acid. Laccaria amethystina degraded ferulic acid to the major metabolite vanillic acid. The intermediate vanillin was not detected. Lactarius deterrimus showed a completely different detoxification pattern.
B, Münzenberger +5 more
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Characterization of physicochemical properties of ferulic acid
Archives of Pharmacal Research, 2003Ferulic acid (3-methoxy, 4-hydroxy cinnamic acid) is a flavoid component possessing antioxidant property. The compound is currently under development as a new drug candidate for the treatment of the dementia. The objective of this preformulation study was to determine the physicochemical properties of ferulic acid.
Young Taek, Sohn, Jin Hee, Oh
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Carbohydrate Polymers, 1993
Abstract Streptomyces olivochromogenes ferulic acid esterase released free ferulic acid from 0-[5-0-(trans-feruloyl)-α- l -arabinofuranosyl]-(1→3)-0-β-xylopyranosyl-(1→4)- d -xylopyranose (FAXX) prepared from wheat bran. The Km and Vmax of the reaction were 0·24 m m and 0·134 U mg−1, respectively.
Craig B. Faulds, Gary Williamson
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Abstract Streptomyces olivochromogenes ferulic acid esterase released free ferulic acid from 0-[5-0-(trans-feruloyl)-α- l -arabinofuranosyl]-(1→3)-0-β-xylopyranosyl-(1→4)- d -xylopyranose (FAXX) prepared from wheat bran. The Km and Vmax of the reaction were 0·24 m m and 0·134 U mg−1, respectively.
Craig B. Faulds, Gary Williamson
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Peroxidase-Catalyzed Oligomerization of Ferulic Acid Esters
Journal of Agricultural and Food Chemistry, 2008Valuable information about possible types of linkages, reaction mechanisms, and sequences for oxidative coupling of phenolic compounds in planta is available from in vitro model systems. Ferulate oligomers were generated in a system using ethyl ferulate, peroxidase, and hydrogen peroxide under various conditions.
Mirko, Bunzel +3 more
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