Results 11 to 20 of about 12,053 (162)

Lagrangian Fibrations

Milan Journal of Mathematics, 2022
AbstractWe review the theory of Lagrangian fibrations of hyperkähler manifolds as initiated by Matsushita. We also discuss more recent work of Shen–Yin and Harder–Li–Shen–Yin. Occasionally, we give alternative arguments and complement the discussion by additional observations.
D. Huybrechts, M. Mauri
openaire   +4 more sources

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

Hepatology, EarlyView., 2022
Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran, Charlotte Wilhelmina Wernberg, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Sofie Marchsteiner Bendixen, Frederik Tibert Larsen, Camilla Dalby Hansen, Lea Ladegaard Grønkjær, Majken Storm Siersbæk, Tina Di Caterino, Sönke Detlefsen, Holger Jon Møller, Lars Grøntved, Kim Ravnskjaer, Søren Kragh Moestrup, Maja Sofie Thiele, Aleksander Krag, Jonas Heilskov Graversen   +17 more
wiley   +1 more source

Double Fibrations

Theory and Applications of Categories, 2022
Comment: 59 ...
Cruttwell, G. S. H., Lambert, M. J., Pronk, D. A., Szyld, M.   +3 more
openaire   +3 more sources

Lipid Messenger Phosphatidylinositol-4,5-Bisphosphate Is Increased by Both PPARα Activators and Inhibitors: Relevance for Intestinal Cell Differentiation

Biology, 2022
We investigated the effects of PPARα activators fenofibrate and WY-14643 as well as the PPARα inhibitor GW6471 on the PI3K/Akt/PTEN pathway of intestinal cell differentiation. Our previous study showed that all these compounds increased the expression of
Katerina Cizkova, Katerina Koubova, Zdenek Tauber   +2 more
doaj   +1 more source

Latent Fibrations: Fibrations for Categories of Partial Maps

Theory and Applications of Categories, 2021
65 pages, submitted to "Theory and Applications of Categories"
Cockett, Robin, Cruttwell, Geoff, Gallagher, Jonathan, Pronk, Dorette   +3 more
openaire   +3 more sources

Equivariant Fibrations

Journal of Mathematical Sciences, 2023
In this paper, we study equivariant Hurewicz fibrations, obtain their internal characteristics, and prove theorems on relationship between equivariant fibrations and fibrations generated by them. Local and global properties of equivariant fibrations are examined.
openaire   +3 more sources

Fenofibrate enhances lipid deposition via modulating PPARγ, SREBP-1c, and gut microbiota in ob/ob mice fed a high-fat diet

Frontiers in Nutrition, 2022
Obesity is characterized by lipid accumulation in distinct organs. Presently, fenofibrate is a commonly used triglyceride-lowering drug. This study is designed to investigate whether long-term fenofibrate intervention can attenuate lipid accumulation in ...
Ying Zhang, Xiu-Bin Jia, Yun-Chao Liu, Wen-Qian Yu, Yan-Hong Si, Yan-Hong Si, Shou-Dong Guo   +6 more
doaj   +1 more source

Concrete Fibrations [PDF]

Notre Dame Journal of Formal Logic, 2017
As far as we know no notion of concreteness for fibrations exists. We introduce such a notion and discuss some basic results about it.
openaire   +4 more sources

Fibrates ameliorate the course of bacterial sepsis by promoting neutrophil recruitment via CXCR2

EMBO Molecular Medicine, 2014
Bacterial sepsis results in high mortality rates, and new therapeutics to control infection are urgently needed. Here, we investigate the therapeutic potential of fibrates in the treatment of bacterial sepsis and examine their effects on innate immunity.
Ivan Tancevski, Manfred Nairz, Kristina Duwensee, Kristina Auer, Andrea Schroll, Christiane Heim, Clemens Feistritzer, Julia Hoefer, Romana R Gerner, Alexander R Moschen, Ingrid Heller, Petra Pallweber, Xiaorong Li, Markus Theurl, Egon Demetz, Anna M Wolf, Dominik Wolf, Philipp Eller, Andreas Ritsch, Guenter Weiss   +19 more
doaj   +1 more source