Results 21 to 30 of about 12,053 (162)

Fibrates: A Possible Treatment Option for Patients with Abdominal Aortic Aneurysm?

open access: yesBiomolecules, 2022
Abdominal aortic aneurysm (AAA) is a life-threatening disease; however, there is no established treatment for patients with AAA. Fibrates are agonists of peroxisome proliferator-activated receptor alpha (PPARα) that are widely used as therapeutic agents ...
Naofumi Amioka, Toru Miyoshi
doaj   +1 more source

HIV: how to manage dyslipidaemia in HIV

open access: yesDrugs in Context, 2022
Background: Dyslipidaemia is a common metabolic condition occurring in people with HIV (PWH), whether treated or untreated with antiretroviral therapy (ART).
Daniel Lee
doaj   +1 more source

Which is the best lipid-modifying strategy in metabolic syndrome and diabetes: fibrates, statins or both?

open access: yesCardiovascular Diabetology, 2004
Although less clinical intervention studies have been performed with fibrates than with statins, there are evidences indicating that fibrates may reduce risk of cardiovascular events. The potential clinical benefit of the fenofibrate will be specified by
Tenenbaum Alexander, Fisman Enrique Z
doaj   +1 more source

Noncommutative fibrations [PDF]

open access: yesCommunications in Algebra, 2019
We show that faithfully flat smooth extensions are reduced flat, and therefore, fit into the Jacobi-Zariski exact sequence in Hochschild homology and cyclic (co)homology even when the algebras are noncommutative or infinite dimensional. We observe that such extensions correspond to tale maps of affine schemes, and we propose a definition for generic ...
openaire   +2 more sources

Hypolipidemic activity of select fibrates correlates to changes in hepatic apolipoprotein C-III expression: a potential physiologic basis for their mode of action.

open access: yesJournal of Lipid Research, 1995
For the last 30 years fibrates have been widely prescribed to treat human dyslipidemia. However, the primary mechanism by which they lower plasma lipid levels is still unknown.
S Haubenwallner   +9 more
doaj   +1 more source

Lipid metabolism dysregulation in diabetic retinopathy

open access: yesJournal of Lipid Research, 2021
: Lipid metabolic abnormalities have emerged as potential risk factors for the development and progression of diabetic complications, including diabetic retinopathy (DR).
Julia V. Busik
doaj   +1 more source

Calibrated fibrations [PDF]

open access: yesCommunications in Analysis and Geometry, 2002
In this paper we investigate the geometry of Calibrated submanifolds and study relations between their moduli-space and geometry of the ambient manifold. In particular for a Calabi-Yau manifold we define Special Lagrangian submanifolds for any Kahler metric on it.
openaire   +2 more sources

Farmacologia do fibratos Pharmacology of fibrates

open access: yesArquivos Brasileiros de Cardiologia, 2005
Os fibratos são as drogas de escolha nas hipertrigliceridemias. Após sua absorção, os fibratos são metabolizados pelo fígado, utilizando isoenzimas P450 não compartilhadas pelas estatinas.
Hermes Toros Xavier
doaj   +1 more source

Fibrates for the Treatment of Primary Biliary Cholangitis Unresponsive to Ursodeoxycholic Acid: An Exploratory Study

open access: yesFrontiers in Pharmacology, 2022
Aim: Up to 40% of patients with primary biliary cholangitis (PBC) will have a suboptimal biochemical response to ursodeoxycholic acid (UDCA), which can be improved by the addition of fibrates.
Guilherme Grossi Lopes Cançado   +23 more
doaj   +1 more source

Análise da Revisão Cochrane: fibratos na prevenção secundária de doença cardiovascular e acidente vascular cerebral

open access: yesRevista Portuguesa de Cardiologia, 2017
Resumo: A influência dos fibratos no risco cardiovascular tem sido o foco de vários ensaios clínicos. Esta revisão sistemática da Cochrane Collaboration avaliou o efeito dos fibratos na prevenção secundária de eventos cardiovasculares e acidente vascular
Gilberto Pires da Rosa   +2 more
doaj   +1 more source

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