Results 51 to 60 of about 12,053 (162)

From Crisis to Diagnosis: A Case of Hypertriglyceridemic Pancreatitis as the First Clinical Presentation of Type 1 Diabetes [PDF]

Journal of Clinical and Diagnostic Research
Acute Pancreatitis (AP) is a prevalent and rapidly progressive inflammatory disorder of the pancreas, often presenting with abdominal pain and elevated serum pancreatic enzymes.
Subashini Vadivel, Sheetal Nandha Kishore, Jagannath S Dhadwad, Janvi Panchal   +3 more
doaj   +1 more source

Safety of Combined Statin and Fibrate Therapy: Risks of Liver Injury and Acute Kidney Injury in a Cohort Study from the Shizuoka Kokuho Database

Drugs - Real World Outcomes
Introduction Statins and fibrates are important means of preventing cardiovascular diseases, particularly when administered in combination as part of various therapeutic strategies.
Yohei Sobukawa, Taichi Hatta, Daito Funaki, Eiji Nakatani   +3 more
doaj   +1 more source

Pyridoxal Reprograms Peroxisomal Hydrogen Peroxide Metabolism to Induce Lethal Oxidative Stress in Ovarian Cancer

iMetaMed, EarlyView.
Pyridoxal (PL) exhibits the strongest anti‐tumor activity within the vitamin B6 family, demonstrating significant ovarian cancer cell‐killing efficacy in vivo, in vitro, and in patient‐derived organoid (PDO) models. The anti‐tumor mechanism involves PL inducing a shift in peroxisome dynamics towards fission, promoting peroxisome proliferation, and ...
Ruonan Li, Huiyan Wang, Dunke Zhang, Qiuying Gu, Jinlong Wang, Bin Liu, Huabin Gao, Jingya Duan, Yimin Liu, Xiaolan Huang, Youquan Bu, Tongchuan He, Hua Linghu   +12 more
wiley   +1 more source

Phase IIb Trial for the Palliative Treatment of Patients With Primary Hepatic Malignancy Unable to Receive Curative Treatment: Efficacy of Colchicine

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This trial was to evaluate the efficacy and the safety of colchicine for the palliative treatment of patients with primary hepatic malignancy unable to receive curative treatment. Forty hepatocellular carcinoma (HCC) patients and two intrahepatic cholangiocarcinoma (ICC) patients signed the informed consents.
Zu‐Yau Lin, Ming‐Lun Yeh, Po‐Cheng Liang, Shinn‐Cherng Chen, Chung‐Feng Huang, Jee‐Fu Huang, Chia‐Yen Dai, Ming‐Lung Yu, Wan‐Long Chuang   +8 more
wiley   +1 more source

Hitchin fibrations are Ngô fibrations

We study the geometry of the Hitchin fibration for $\mathcal{L}$-valued $G$-Higgs bundles over a smooth projective curve of genus $g$, where $G$ is a reductive group and $\mathcal{L}$ is a suitably positive line bundle. We show that the Hitchin fibration admits the structure of a weak Abelian fibration. In the case when the line bundle $\mathcal{L}$ is
de Cataldo, Mark Andrea, Fringuelli, Roberto, Herrero, Andres Fernandez, Mauri, Mirko   +3 more
openaire   +2 more sources

Lefschetz Fibrations and real Lefschetz fibrations

Winter Braids Lecture Notes, 2015
This note is based on the lectures that I have given during the winter school Winter Braids IV, School on algebraic and topological aspects of braid groups held in Dijon on 10 - 13 February 2014. The aim of series of three lectures was to give an overview of geometrical and topological properties of 4-dimensional Lefschetz fibrations.
openaire   +1 more source

Systemic medications associate with surgically treated cataract among adults over 50 years in Finland

Acta Ophthalmologica, EarlyView.
Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen, Jari Haukka, Tuomas Lilius, Sirpa Loukovaara   +3 more
wiley   +1 more source

FIBRATES SEEM TO BE EQUALLY EFFECTIVE AS SECOND-LINE THERAPY IN PRIMARY BILIARY CHOLANGITIS, WITH BIOCHEMICAL RESPONSE PLATEAUING AT 6 MONTHS

Annals of Hepatology
Introduction and Objectives: Approximately 40% of patients with primary biliary cholangitis (PBC) exhibit an incomplete biochemical response to ursodeoxycholic acid (UDCA) and require second-line therapy.
Guilherme Grossi Lopes Cançado, María Lucía Ferraz, Debora Raquel Benedita Terrabuio, Alejandra Villamil, Lorena Castro Solari, Graciela Elia Castro-Narro, Ezequiel Ridruejo, Cristiane A. Villela-Nogueira, Malen L. Fernandes, Daniela Chiodi, Carla Enrique, Paulo Lisboa Bittencourt, Gustavo Pereira, Fernando Bessone, Eira Cerda, Rodrigo Zapata, Hugo Cheinquer, Álvaro Urzúa, Manuel Mendizabal, Liliana Sampaio Costa Mendes, Pablo Andrés Coste Murillo, Janaina L. Narciso-Schiavon, Fernanda A. Gelape, Vinicius A. Santos, Raimundo de Araujo Gama, Ana Cristina Amaral, Mario Guimarães Pessoa, Sarah Rufino, Eduardo Luiz Rachid Cançado, Andreína Fragens, Natalia Sobenko, Franco Weisser Vuskovic, Gabriel Mezzano Puentes, Mirta Peralta, Harlim Rodrigues, Lívia Villela Nogueira, Vivian Rotman, Federico Orozco, Nelia Hernandez, Claudia Alves Couto   +39 more
doaj   +1 more source

Comparison of SGLT2 Inhibitors for New‐Onset Proteinuria Risk in Patients With Type 2 Diabetes and Preserved Kidney Function

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To compare the effects of individual SGLT2 inhibitors on preventing new‐onset proteinuria in patients with type 2 diabetes and preserved kidney function. Materials and Methods A target trial emulation was performed using commercially available databases, including health checkups and claims data, between April 1, 2014 and March 31, 2023 ...
Hiroki Nobayashi, Michihiro Satoh, Takuo Hirose, Shingo Nakayama, Yutaro Iwabe, Hideaki Hashimoto, Takahisa Murakami, Kouji Okada, Takefumi Mori, Hirohito Metoki   +9 more
wiley   +1 more source

Constructing approximate fibrations [PDF]

Transactions of the American Mathematical Society, 1983
In this paper two results concerning the construction of approximate fibrations are established. The first shows that there are approximate fibrations p : M → S 2 p:M \to S^2 which are homotopic to bundle maps but which cannot be approximated by bundle maps. Here M
Chapman, T. A., Ferry, Steve
openaire   +2 more sources