Results 71 to 80 of about 14,279 (236)

The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its comorbidities

British Journal of Pharmacology, EarlyView.
The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli, Alessia Campagna, Barbara Eramo, Christian Sepe, Annarita Zuena, Silvana Gaetani, Adele Romano   +6 more
wiley   +1 more source

Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates. [PDF]

Epidemiological and transgenic animal studies have implicated apo C-III as a major determinant of plasma triglyceride metabolism. Since fibrates are very efficient in lowering triglycerides, it was investigated whether fibrates regulate apo C-III gene ...
Saladin, R, Staels, B, Dallongeville, J, Auwerx, J, Fruchart, J C, Vu-Dac, N, Kosykh, V A   +6 more
core   +2 more sources

Macrophage Lipid Homeostasis Drives IVDD via a Senescence‐Dependent Impairment of Efferocytosis

Cell Proliferation, EarlyView.
Intervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Jinyu Wang, Shiyong Ling, Qi Wang, Xuege Qiao, Jianpeng Xing, Siyang Ji, Linhui Han, Chen Yan, Zhishen Niu, Lei Yuan, Baolian Zhao, Kaiqiang Sun, Jiangang Shi   +12 more
wiley   +1 more source

FIBRATES SEEM TO BE EQUALLY EFFECTIVE AS SECOND-LINE THERAPY IN PRIMARY BILIARY CHOLANGITIS, WITH BIOCHEMICAL RESPONSE PLATEAUING AT 6 MONTHS

Annals of Hepatology
Introduction and Objectives: Approximately 40% of patients with primary biliary cholangitis (PBC) exhibit an incomplete biochemical response to ursodeoxycholic acid (UDCA) and require second-line therapy.
Guilherme Grossi Lopes Cançado, María Lucía Ferraz, Debora Raquel Benedita Terrabuio, Alejandra Villamil, Lorena Castro Solari, Graciela Elia Castro-Narro, Ezequiel Ridruejo, Cristiane A. Villela-Nogueira, Malen L. Fernandes, Daniela Chiodi, Carla Enrique, Paulo Lisboa Bittencourt, Gustavo Pereira, Fernando Bessone, Eira Cerda, Rodrigo Zapata, Hugo Cheinquer, Álvaro Urzúa, Manuel Mendizabal, Liliana Sampaio Costa Mendes, Pablo Andrés Coste Murillo, Janaina L. Narciso-Schiavon, Fernanda A. Gelape, Vinicius A. Santos, Raimundo de Araujo Gama, Ana Cristina Amaral, Mario Guimarães Pessoa, Sarah Rufino, Eduardo Luiz Rachid Cançado, Andreína Fragens, Natalia Sobenko, Franco Weisser Vuskovic, Gabriel Mezzano Puentes, Mirta Peralta, Harlim Rodrigues, Lívia Villela Nogueira, Vivian Rotman, Federico Orozco, Nelia Hernandez, Claudia Alves Couto   +39 more
doaj   +1 more source

Hitchin fibrations are Ngô fibrations

We study the geometry of the Hitchin fibration for $\mathcal{L}$-valued $G$-Higgs bundles over a smooth projective curve of genus $g$, where $G$ is a reductive group and $\mathcal{L}$ is a suitably positive line bundle. We show that the Hitchin fibration admits the structure of a weak Abelian fibration. In the case when the line bundle $\mathcal{L}$ is
de Cataldo, Mark Andrea, Fringuelli, Roberto, Herrero, Andres Fernandez, Mauri, Mirko   +3 more
openaire   +2 more sources

Mirrorfolds with K3 fibrations

Journal of High Energy Physics, 2008
Eqns (2.61) and (3.17 ...
Kawai, Shinsuke, Sugawara, Yuji
openaire   +2 more sources

Early Worsening of Diabetic Retinopathy Following Initiation of Hybrid Closed‐Loop/Automated Insulin Delivery Systems in Type 1 Diabetes: A Systematic Review and Structured Study‐Level Synthesis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Hybrid closed‐loop (HCL) systems achieve rapid, algorithm‐driven improvements in glycaemia in type 1 diabetes (T1D). Paradoxically, rapid improvement in glycaemic control is associated with early worsening of diabetic retinopathy (EWDR), a phenomenon established in the intensive insulin therapy era.
Matthew Anson, Ahmed Iqbal, Shazli Azmi, Philip Weston, Lucy Hughes, Mahreen Choudhury, David M. Hughes, Yalin Zheng, Philip I. Burgess, Uazman Alam   +9 more
wiley   +1 more source

Efficacy and Safety of SGLT2 Inhibitors in Patients With Genetic Lipodystrophy: A Real‐Life Experience From a National Reference Network

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim Lipodystrophy syndromes are rare diseases with metabolic and cardiovascular consequences. This study explores the metabolic and renal effects of sodium‐glucose cotransporter 2 inhibitors (SGLT2i) in patients with genetic lipodystrophy. Patients and Methods Patients with familial partial lipodystrophy (n = 57) or congenital generalised ...
Léna Robert, Ines Belalem, Corinne Vigouroux, Hippolyte Dupuis, Marie Christine Vantyghem, Mathilde Simonson, Estelle Nobecourt, Héléna Mosbah, Sophie Beliard, Stéphanie Jellimann, Sonja Janmaat, Camille Vatier, Sophie Lamothe   +12 more
wiley   +1 more source

Primary sclerosing cholangitis response to the combination of fibrates with ursodeoxycholic acid: French–Spanish experience

, 2018
International audienceBACKGROUND & AIMS: In patients with primary sclerosing cholangitis (PSC), ursodeoxycholic acid (UDCA) treatment improves serum liver tests and surrogate markers of prognosis but has no proven effect on survival. Additional therapies
Kemgang Fankem, Astrid Donald, Poupon, Raoul, Housset, Chantal, Belkacem, Karima, Ben, Pares, Albert, Gaouar, Farid, Corpechot, Christophe, Chazouillères, Olivier, Lemoinne, Sara, Reig, Anna   +9 more
core   +1 more source

Dyslipidaemia, Chronic Kidney Disease and Diabetes Mellitus: A Triple Threat to Cardiovascular Health

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Diabetes mellitus (DM) and chronic kidney disease (CKD) frequently coexist and together create a ‘triple threat’ with dyslipidaemia, enhancing the risk for cardiovascular morbidity and mortality. Diabetic kidney disease (DKD) leads to altered lipid metabolism through insulin resistance, inflammation and oxidative stress resulting in an ...
Ann S. Forrest, Priyanka Majety, Stéphanie B. Mayer, Om P. Ganda   +3 more
wiley   +1 more source