Results 61 to 70 of about 14,040 (225)

Fenofibrate Decreases Ethanol-Induced Neuroinflammation and Oxidative Stress and Reduces Alcohol Relapse in Rats by a PPAR-α-Dependent Mechanism

open access: yesAntioxidants, 2023
High ethanol consumption triggers neuroinflammation, implicated in sustaining chronic alcohol use. This inflammation boosts glutamate, prompting dopamine release in reward centers, driving prolonged drinking and relapse.
Cristina Ibáñez   +5 more
doaj   +1 more source

Mécanismes d'action des statines et des fibrates

open access: yes, 2007
Les statines et les fibrates constituent les deux classes majeures d'hypolipémiants. Les statines sont utilisées dans le traitement des hypercholestérolémies essentielles et des hyperlipidémies mixtes, alors que les fibrates sont employés dans celui des ...
Patrick Duriez
core   +1 more source

Lipid-lowering therapy in the outpatient practice

open access: yesМедицинский совет, 2013
The review focuses on the importance of primary and secondary prevention of cardiovascular disease in outpatient settings, and principles of effective and safe use of modern lipid-lowering drugs.
S. A. Urazgildeyeva
doaj   +1 more source

Repurposing Peroxisome Proliferator-Activated Receptor Agonists in Neurological and Psychiatric Disorders

open access: yesPharmaceuticals, 2021
Common pathophysiological mechanisms have emerged for different neurological and neuropsychiatric conditions. In particular, mechanisms of oxidative stress, immuno-inflammation, and altered metabolic pathways converge and cause neuronal and non-neuronal ...
Claudia Sagheddu   +3 more
doaj   +1 more source

Fibrations of graphs

open access: yesDiscrete Mathematics, 2002
A fibration of graphs is a morphism that is a local ismorphism of in-neighbourhoods, much in the same way a covering projection is a local isomorphism of neighbourhoods. The authors develop systematically the theory of graph fibrations, with a special emphasis on results related to some applications in computer science.
P. Boldi, S. Vigna
openaire   +2 more sources

Inhibitory action of gemfibrozil on cholesterol absorption in rat intestine

open access: yesJournal of Lipid Research, 2001
This study was designed to determine whether gemfibrozil inhibits intestinal lipid absorption. Male Sprague-Dawley rats received an oral dose of 30 mg gemfibrozil/kg body weight for 14 days.
Yoh Umeda   +6 more
doaj   +1 more source

Effects of Hypolipidemic Drugs on Psoriasis

open access: yesMetabolites, 2023
Psoriasis is a chronic, systematic, inflammatory disease in which multiple metabolic and immunologic disturbances lead to lipid abnormalities, impaired glucose tolerance, metabolic syndrome, diabetes mellitus, atherosclerosis, hypertension, ischemic ...
Mateusz Matwiejuk   +4 more
doaj   +1 more source

Mode‐of‐Action and Human Relevance Assessment for Diisononyl Phthalate‐Induced Liver Tumors in Rodents

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Diisononyl phthalate (DINP) is a high molecular weight phthalate and high production volume chemical. DINP's carcinogenic potential has been investigated in four rodent bioassays, with liver tumors observed in three of the studies. Authoritative assessments have hypothesized that DINP acts through the peroxisome proliferator‐activated receptor
Amanda N. Buerger   +3 more
wiley   +1 more source

Systemic medications associate with surgically treated cataract among adults over 50 years in Finland

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen   +3 more
wiley   +1 more source

Fibrates for primary prevention of cardiovascular disease events

open access: yes, 2012
This is the protocol for a review and there is no abstract. The objectives are as follows: To assess the clinical benefit and harm of fibrates versus placebo or usual care or fibrates plus other lipid-modifying drugs versus other lipid-modifying drugs ...
Benjamin Kasenda   +13 more
core   +1 more source

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