Results 61 to 70 of about 14,279 (236)

Current and future opportunities for the management of primary biliary cholangitis

Frontiers in Gastroenterology, 2023
Primary biliary cholangitis (PBC) is a rare immune-mediated chronic cholestatic liver disease that can progress to liver fibrosis and, ultimately, cirrhosis if left untreated.
Sandra Naffouj, Jennifer Wang
doaj   +1 more source

Fibrations of graphs

Discrete Mathematics, 2002
A fibration of graphs is a morphism that is a local ismorphism of in-neighbourhoods, much in the same way a covering projection is a local isomorphism of neighbourhoods. The authors develop systematically the theory of graph fibrations, with a special emphasis on results related to some applications in computer science.
P. Boldi, S. Vigna
openaire   +3 more sources

Inhibitory action of gemfibrozil on cholesterol absorption in rat intestine

Journal of Lipid Research, 2001
This study was designed to determine whether gemfibrozil inhibits intestinal lipid absorption. Male Sprague-Dawley rats received an oral dose of 30 mg gemfibrozil/kg body weight for 14 days.
Yoh Umeda, Yuko Kako, Kayo Mizutani, Yohji Iikura, Mitsunobu Kawamura, Mitsuru Seishima, Hiroshi Hayashi   +6 more
doaj   +1 more source

Flavonoids and fibrate modulate apoE4-induced processing of amyloid precursor protein in neuroblastoma cells

Frontiers in Neuroscience, 2023
IntroductionApolipoprotein (apo) E4, being a major genetic risk factor for Alzheimer’s disease (AD), is actively involved in the proteolytic processing of amyloid precursor protein (APP) to amyloid β (Aβ) peptide, the principle constituent of amyloid ...
Viralkumar Davra, Kenza E. Benzeroual
doaj   +1 more source

Mode‐of‐Action and Human Relevance Assessment for Diisononyl Phthalate‐Induced Liver Tumors in Rodents

Journal of Applied Toxicology, EarlyView.
ABSTRACT Diisononyl phthalate (DINP) is a high molecular weight phthalate and high production volume chemical. DINP's carcinogenic potential has been investigated in four rodent bioassays, with liver tumors observed in three of the studies. Authoritative assessments have hypothesized that DINP acts through the peroxisome proliferator‐activated receptor
Amanda N. Buerger, Melissa M. Heintz, Laurie C. Haws, Chad M. Thompson   +3 more
wiley   +1 more source

Fibrates for primary prevention of cardiovascular disease events

, 2012
This is the protocol for a review and there is no abstract. The objectives are as follows: To assess the clinical benefit and harm of fibrates versus placebo or usual care or fibrates plus other lipid-modifying drugs versus other lipid-modifying drugs ...
Benjamin Kasenda, Ramon Saccilotto, Saccilotto, Ramon, Alain J Nordmann, Dirk Bassler, Nordmann, Alain J., Bassler, Dirk, Neera Bhatnagar, Matthias Briel, Ferreira-González, Ignacio, Briel, Matthias, Bhatnagar, Neera, Kasenda, Benjamin, Ignacio Ferreira-González   +13 more
core   +1 more source

Effects of post‐hepatic portoenterostomy adjuvant therapy on liver transplantation in children with biliary atresia: A systematic review

JPGN Reports, EarlyView.
Abstract Objectives Biliary atresia (BA) is a cholangiopathy characterized by obstruction of the intrahepatic and extrahepatic bile ducts. Hepatic portoenterostomy (HPE) is the primary palliative treatment and there is still an urgent need to improve post‐HPE management.
Bianca Ferraz de Almeida Silva, Alice Palmeira Nascimento Cerqueira, Breno Oliveira Marques, Gabriela Garcia de Carvalho Laguna, Gabrielle dos Santos Aguiar, Luana Leal Gonzaga, Raquel Teles de Lacerda, Natalia Oliveira e Silva   +7 more
wiley   +1 more source

From Crisis to Diagnosis: A Case of Hypertriglyceridemic Pancreatitis as the First Clinical Presentation of Type 1 Diabetes [PDF]

Journal of Clinical and Diagnostic Research
Acute Pancreatitis (AP) is a prevalent and rapidly progressive inflammatory disorder of the pancreas, often presenting with abdominal pain and elevated serum pancreatic enzymes.
Subashini Vadivel, Sheetal Nandha Kishore, Jagannath S Dhadwad, Janvi Panchal   +3 more
doaj   +1 more source

Hyperhomocysteinemia and Vitamin B Deficiency as Potential Aggravating Factors in Huntington's Disease: A Prospective Monocentric Study

Movement Disorders, EarlyView.
Abstract Background Although not confirmed, some studies have suggested that elevated homocysteine levels are common in patients with Huntington's disease (HD). Its clinical relevance remains unclear. Objectives We aimed to assess vitamin B and homocysteine levels in HD patients and explore the relationships among hyperhomocysteinemia, vitamin B ...
Salomé Puisieux, Elise Pourié, Céline Bonnet, Lucie Hopes, Solène Frismand, Myriam Bronner, Virginie Roth, Marion Wandzel, Natacha Sloboda, Laetitia Lambert, Abderrahim Oussalah, Amélia Julien, Irina Rotaru, Rosa‐Maria Guéant‐Rodriguez, Jean Louis Guéant, Carine Bossenmeyer‐Pourié, Mathilde Renaud   +16 more
wiley   +1 more source

Safety of Combined Statin and Fibrate Therapy: Risks of Liver Injury and Acute Kidney Injury in a Cohort Study from the Shizuoka Kokuho Database

Drugs - Real World Outcomes
Introduction Statins and fibrates are important means of preventing cardiovascular diseases, particularly when administered in combination as part of various therapeutic strategies.
Yohei Sobukawa, Taichi Hatta, Daito Funaki, Eiji Nakatani   +3 more
doaj   +1 more source