Results 51 to 60 of about 14,279 (236)

Disentangling Sex Differences in Sulfonylurea Drug Response With Genome‐Wide Association Studies in Individuals With Type 2 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
A sex‐stratified genome‐wide association study of sulfonylurea response identified sex‐specific genetic loci associated with HbA1c reduction in individuals with type 2 diabetes. Replication and functional validation supported a male‐specific association at the TMEM64/NECAB1 locus, highlighting the potential of sex‐informed pharmacogenomics to advance ...
Joseph H. Breeyear, John S. House, Mark Kvale, Stella Nam, Farida S. Akhtari, Hetal S. Shah, Monique M. Hedderson, Kathleen M. Giacomini, Josyf C. Mychaleckyj, Alessandro Doria, Michael J. Wagner, Josephine H. Li, Sook Wah Yee, John B. Buse, Richard P. Woychik, Daniel M. Rotroff, Alison A. Motsinger‐Reif   +16 more
wiley   +1 more source

Induction of 1-Acylglycerophosphocholine Acyltransferase Genes by Fibrates in the Liver of Rats [PDF]

, 2012
The effect of fibrates (clofibric acid, bezafibrate and fenofibrate) on the gene expression and activity of 1-acylglycerophosphocholine acyltransferase (LPCAT) was investigated.
川嶋, 洋一, 光本, 篤史, 田中, 静代, 坂本, 武史, 山崎, 研, 若林, 美智子, 池田, 英里香, 工藤, なをみ   +7 more
core   +1 more source

Ciprofibrate therapy in patients with hypertriglyceridemia and low high density lipoprotein (HDL)-cholesterol: greater reduction of non-HDL cholesterol in subjects with excess body weight (The CIPROAMLAT study)

Cardiovascular Diabetology, 2004
Background Hypertriglyceridemia in combination with low HDL cholesterol levels is a risk factor for cardiovascular disease. Our objective was to evaluate the efficacy of ciprofibrate for the treatment of this form of dyslipidemia and to identify factors ...
Medel Octavio, Hernández Ismael, Salinas Saul, Vazquez Cuauhtémoc, Ramírez Erika, Jiménez Sergio, Hernández Ma, Florenzano Fernando, Saavedra Victor, Reyes Eliana, Machado Carlos, Oliveira José, Torres Kerginaldo, Rabelo Lísia, Neto Abrahão, Filho José, Rengifo Hector, Stockins Benjamín, Aguilar-Salinas Carlos A, Assis-Luores-Vale Andréia, Moreno Ricardo, Lugo Paula, Alvarado Ricardo, Mehta Roopa, Gutierrez Victor, Gómez Pérez Francisco J   +25 more
doaj   +1 more source

Lefschetz Fibrations and real Lefschetz fibrations

Winter Braids Lecture Notes, 2015
This note is based on the lectures that I have given during the winter school Winter Braids IV, School on algebraic and topological aspects of braid groups held in Dijon on 10 - 13 February 2014.
openaire   +1 more source

Food‐grade proteins, lipids, and fibers as potential tools to ameliorate cardiovascular disorders: A review

Food Biomacromolecules, EarlyView.
Abstract Cardiovascular diseases (CVDs) remain the leading cause of global mortality, necessitating effective preventive and adjunct therapeutic strategies beyond conventional pharmacological interventions. Although previous reviews have focused on individual nutrients or dietary patterns, this review provides a mechanism‐based, integrative perspective
Sridevi Shanmugam, Rukaiah Fatma Begum, Nirenjen Shanmugasundaram, Bhupendra Gopalbhai Prajapati, Suresh Ankul Singh, Pavithra Nagenthran, Sudarshan Singh, Kesarla Rajesh   +7 more
wiley   +1 more source

Fibrates in the prevention of cardiovascular disease in patients with type 2 diabetes mellitus: meta-analysis of randomised controlled trials

, 2006
To assess the impact of lipid lowering treatment with fibrates on cardiovascular endpoints in patients with type 2 diabetes ...
Allemann, Sabin, Egger, Matthias, Christ, Emanuel R, Diem, Peter, Stettler, Christoph   +4 more
core   +1 more source

Isolated low high density lipoprotein-cholesterol (HDL-C): implications of global risk reduction. Case report and systematic scientific review

Cardiovascular Diabetology, 2005
Background The importance of low high-density lipoprotein cholesterol (HDL-C), elevated non HDL-C (as part of the metabolic syndrome, prediabetes, and type 2 diabetes mellitus), and an isolated low HDL-C is rapidly emerging. The antiatherosclerotic roles
Tyagi Suresh C, Hayden Melvin R
doaj   +1 more source

Fenofibrate (a PPAR-α Agonist) Administered During Ethanol Withdrawal Reverts Ethanol-Induced Astrogliosis and Restores the Levels of Glutamate Transporter in Ethanol-Administered Adolescent Rats

Frontiers in Pharmacology, 2021
High-ethanol intake induces a neuroinflammatory response, which has been proposed as responsible for the maintenance of chronic ethanol consumption. Neuroinflammation decreases glutamate transporter (GLT-1) expression, increasing levels of glutamate that
Francisca Villavicencio-Tejo, Osvaldo Flores-Bastías, Lucas Marambio-Ruiz, Diliana Pérez-Reytor, Eduardo Karahanian   +4 more
doaj   +1 more source

Mécanismes d'action des statines et des fibrates

, 2007
Les statines et les fibrates constituent les deux classes majeures d'hypolipémiants. Les statines sont utilisées dans le traitement des hypercholestérolémies essentielles et des hyperlipidémies mixtes, alors que les fibrates sont employés dans celui des ...
Patrick Duriez
core   +1 more source

Lipid-lowering therapy in the outpatient practice

Медицинский совет, 2013
The review focuses on the importance of primary and secondary prevention of cardiovascular disease in outpatient settings, and principles of effective and safe use of modern lipid-lowering drugs.
S. A. Urazgildeyeva
doaj   +1 more source