Results 81 to 90 of about 12,053 (162)

Fibred fibration categories [PDF]

2017 32nd Annual ACM/IEEE Symposium on Logic in Computer Science (LICS), 2017
We introduce fibred type-theoretic fibration categories which are fibred categories between categorical models of Martin-L f type theory. Fibred type-theoretic fibration categories give a categorical description of logical predicates for identity types. As an application, we show a relational parametricity result for homotopy type theory.
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Adverse Effects of Fenofibrate in Mice Deficient in the Protein Quality Control Regulator, CHIP

Journal of Cardiovascular Development and Disease, 2018
We previously reported how the loss of CHIP expression (Carboxyl terminus of Hsc70-Interacting Protein) during pressure overload resulted in robust cardiac dysfunction, which was accompanied by a failure to maintain ATP levels in the face of increased ...
Saranya Ravi, Traci L. Parry, Monte S. Willis, Pamela Lockyer, Cam Patterson, James R. Bain, Robert D. Stevens, Olga R. Ilkayeva, Christopher B. Newgard, Jonathan C. Schisler   +9 more
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Chemical degradation kinetics of fibrates: bezafibrate, ciprofibrate and fenofibrate

Brazilian Journal of Pharmaceutical Sciences
Fibrates are drugs used for the treatment of hypertriglyceridemia and for the prevention of atherosclerosis. Three drugs in the fibrate class, ciprofibrate, fenofibrate and bezafibrate, were chosen for this study because their raw materials are readily ...
Marcelo Antonio de Oliveira, Gerliane Damázio da Silva, Michele Soares Tacchi Campos   +2 more
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LPL gene variants affect apoC-III response to combination therapy of statins and fenofibric acid in a randomized clinical trial of individuals with mixed dyslipidemia

Journal of Lipid Research, 2012
ApoC-III is a proatherogenic protein associated with elevated triglycerides; its deficiency is associated with reduced atherosclerosis. Mixed dyslipidemia, characterized by elevated triglyceride and apoC-III levels and low HDL cholesterol level, with or ...
Ariel Brautbar, Salim S. Virani, John Belmont, Vijay Nambi, Peter H. Jones, Christie M. Ballantyne   +5 more
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s-Fibrations [PDF]

Fundamenta Mathematicae, 1980
Husch, L. S., Stoughton, J. R.
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Itching for Answers: A Comprehensive Review of Cholestatic Pruritus Treatments

Biomolecules
Cholestasis is a clinical and laboratory syndrome indicating impaired bile production or excretion. One of the hallmark symptoms of cholestasis is pruritus.
Filippo Gabrielli, Eleonora Crepaldi, Alessia Cavicchioli, Marco Rivi, Arianna Carmen Costanzo, Carmela Cursaro, Pietro Andreone   +6 more
doaj   +1 more source

Pleiotropic Effects of Peroxisome Proliferator-Activated Receptor Alpha and Gamma Agonists on Myocardial Damage: Molecular Mechanisms and Clinical Evidence—A Narrative Review

Cells
Cardiovascular diseases remain the leading cause of death in the world, and that is why finding an effective and multi-functional treatment alternative to combat these diseases has become more important.
María Esther Rubio-Ruíz, Juan Carlos Plata-Corona, Elizabeth Soria-Castro, Julieta Anabell Díaz-Juárez, María Sánchez-Aguilar   +4 more
doaj   +1 more source

Targeting Cardiac Metabolism in Heart Failure with PPARα Agonists: A Review of Preclinical and Clinical Evidence

Biomedicines
Background and objective: Heart failure (HF) is associated with high morbidity, mortality, and healthcare costs. Its prevalence continues to rise, particularly in the context of ageing populations and increasing rates of metabolic comorbidities such as ...
Carla Handford, Laura Stirling-Barros, Mahboube Ganji-Arjenaki, Masliza Mahmod, Milad Nazarzadeh, Malgorzata Wamil   +5 more
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Principal Fibrations [PDF]

Transactions of the American Mathematical Society, 1963
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Discrete 2-fibrations

Higher Structures
This paper is concerned with developing a 2-dimensional analogue of the notion of an ordinary discrete fibration. A definition is proposed, and it is shown that such discrete 2-fibrations correspond via a 2-equivalence to certain category-valued 2-functors.
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