Results 191 to 200 of about 18,150,697 (227)
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The role of the fibrinolytic system in thromboembolism
Progress in Cardiovascular Diseases, 1979The present concept of physiologic fibrinolysis was reviewed. It was concluded that the nonspecific proteolytic activity of plasmin would essentially be limited to fibrin in vivo in view of (A) the specific adsorption of activator and of plasminogen onto the fibrin surface resulting in local generation of plasmin and (B) the fact that plasmin ...
J G, Vermylen, D A, Chamone
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The Fibrinolytic System in Peripartum Depression
Seminars in Thrombosis and Hemostasis, 2022AbstractThe relationship between depression and reduced fibrinolytic activity reflects the role of tissue plasminogen activator and plasmin in brain remodeling underlying resilience, depression remission, and reward processing, rather than the dissolution of fibrin clots.
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An assessment of the fibrinolytic system in hemophilia A
American Journal of Hematology, 1982AbstractThe fibrinolytic system was assessed in 28 hemophiliacs using the chromogenic substrate H‐D‐Val‐Leu‐Lys‐pNA. To determine whether a state of hyperfibrinolysis might be associated with Factor VIII replacement therapy, 14 patients with severe disease who were intensively treated with Factor VIII concentrates were compared with 14 patients with ...
M E, Eyster +3 more
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The Fibrinolytic System in Neoplasia
Seminars in Thrombosis and Hemostasis, 1996During activation of the fibrinolytic system plasminogen is converted to plasmin by tissue plasminogen activator (t-PA) or urokinase-type plasminogen activator (u-PA). t-PA is predominantly released from endothelial cells, u-PA primarily by renal parenchymal cells. The activation of plasminogen is regulated by plasminogen activator inhibitor-1 (PAI-1),
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The Fibrinolytic System in Human Ascites
Scandinavian Journal of Gastroenterology, 1995We recently reported that the contact and kallikrein-kinin systems are activated in malignancy-related ascites. We have now studied the fibrinolytic system in ascites and plasma from patients with gastrointestinal cancer(n = 14) and non-malignant liver disease (n = 18).Enzyme immunoassays (EIAs) showed that urokinase and tissue plasminogen activators ...
L, Buø +6 more
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Obesity, haemostasis and the fibrinolytic system
Obesity Reviews, 2002SummaryObese patients are at risk for the development of cardiovascular diseases, which can in part be explained by disturbances in the haemostatic and fibrinolytic systems. Indeed, obese subjects tend to have higher values of fibrinogen, factor VII, factor VIII, von Willebrand factor and plasminogen activator inhibitor compared to non‐obese subjects ...
Mertens, I., Van Gaal, L.
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The fibrinolytic system—Basic considerations
Progress in Cardiovascular Diseases, 1979T HE fibrinolytic system consists basically of fibrinogen, fibrin, plasminogen, plasmin, and activators of plasminogen. Plasmin, however, appears to be implicated in pathways other than fibrinolysis or fibrinogenolysis. For example, plasmin is capable of digesting factor Xlla to factor Xlla fragments which, in turn, are potent activators of ...
F J, Castellino, B N, Violand
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Lactones as Inhibitors of the Fibrinolytic System
Science, 1967Caprolactone, valerolactone, and butyrolactone inhibit proteolytic and fibrinolytic activities of human plasmin. In very low concentrations, they also inhibit activation of plasminogen through plasmin-streptokinase activator and human urokinase. The degree of inhibitory potency depends upon the number of carbon atoms in the lactone.
W, Auerswald, W, Doleschel
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Tumor interaction with the fibrinolytic system
Journal of Surgical Research, 1979Abstract Tumor activation and inhibition of fibrinolysis appear to be related to the pathophysiology of metastatic tumor spread. Our data demonstrate a correlation between the incidence of tumor metastases and both increasing tumor fibrinolytic activator activity and decreasing tumor fibrinolytic inhibitory activity.
J M, Malone +3 more
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The Fibrinolytic System of the Vascular Wall
Clinics in Haematology, 1985The vascular endothelium produces both PAs and a PAI. The activities of these components in the circulation must be regulated precisely to ensure that normal vascular homeostasis is not compromised. The blood contains a number of molecules that may function in this way by either promoting or inhibiting the synthesis, release and/or activity of the PAs ...
L A, Erickson +3 more
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