Results 201 to 210 of about 280,507 (256)

Dysregulation of the MACF1‐Rab14/KIF16B‐FGFR Vesicular Trafficking Axis Skews MSC Lineage Commitment in Glucocorticoid‐Induced Osteoporosis

Advanced Science, EarlyView.
Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su, Ye Tian, Fan Zhao, Jing Li, Suryaji Patil, Chunyu Zhu, Yujia Tian, Junrong Wang, Jiating Liu, Aoqi Xiang, Hua Guan, Lusha Zhang, Xiaochang Chen, Airong Qian, Qi Yu   +14 more
wiley   +1 more source

Therapeutic Applications of Fibroblast Activation Protein (FAP)-Binding Radiopharmaceuticals: Review of Opportunities and Challenges. [PDF]

Cancers (Basel)
Maes J, Pôlet B, Kleynhans J, Van Herpe F, Goffin K, Dekervel J, Nafteux P, Topal B, Cleeren F, Deroose CM.   +9 more
europepmc   +1 more source

BraMARS: An Interpretable Histopathology‐Driven Deep Learning Model for Brain Metastasis Risk Stratification in Surgically Resected Limited‐Stage SCLC

Advanced Science, EarlyView.
This study presents BraMARS, an explainable deep learning model that estimates future brain metastasis risk in surgically resected limited‐stage small‐cell lung cancer using routine H&E‐stained whole‐slide images. By linking model‐attributed spatial histopathology with clinical outcomes and proteomic programs, BraMARS provides a biologically ...
Zijian Yang, Taolue Wang, Shilong Liu, Zicheng Zhang, Yibo Zhang, Fan Yang, Bo Yu, Shuaishuai Gao, Yu Chen, Lin Yang, Meng Zhou   +10 more
wiley   +1 more source

CAR-T cells targeting fibroblast activation protein eliminate pathological fibroblasts and preserve cardiac function in a Duchenne Muscular Dystrophy murine model. [PDF]

Stem Cell Res Ther
Marigny C, Revet G, Berger A, Boulch M, Mougenot N, Li Z, Corre B, Lemaitre M, Bois A, Castelli C, Collombat V, Parlakian A, Perier MC, Bot A, Epstein JA, Lafuste P, Hagege A, Aghajanian H, Cochain C, Bousso P, Agbulut O, Menasché P.   +21 more
europepmc   +1 more source

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source

Correction: Combined antitumor activity of [177Lu]Lu-FAPI-2286 and pazopanib in a sarcoma model: a preclinical theranostic study targeting fibroblast activation protein. [PDF]

EJNMMI Res
Tseng JR, Hsu CL, Hsieh HH, Ho KC, Wu CY, Lin KH, Chung YH, Weng CC.   +7 more
europepmc   +1 more source

Transcriptomic profiling across stages of non-muscle-invasive bladder cancer identifies fibroblast activation protein-alpha as a stromal biomarker associated with progression. [PDF]

Mol Med
Akand M, Nakauma-González JA, Jatsenko T, Gevaert T, Baekelandt L, Baldewijns M, Vermeesch JR, Van der Aa F, Joniau S.   +8 more
europepmc   +1 more source

Inhibition of Fibroblast Activation Protein-α Ameliorates Intervertebral Disc Degeneration via Reduced Vascular Invasion in Cartilage Endplate. [PDF]

Cell Prolif
Xu HW, Chang SJ, Wang S, Liu XW, Wang SJ.   +4 more
europepmc   +1 more source

Fibroblast Activation Protein Alpha-Targeted Nanoparticles for Tumor Microenvironment Remodeling and Antitumor Therapy in Triple-Negative Breast Cancer. [PDF]

Biomater Res
Lameirinhas A, Díez P, Hicke FJ, Ágreda-Roca A, Torres-Ruiz S, Sánchez-Serrano P, Tapia M, Lluch A, Bermejo B, Cejalvo JM, Martínez-Máñez R, Eroles P, Garrido-Cano I.   +12 more
europepmc   +1 more source

Is There an Added Value of Dual-Time-Point [⁶⁸Ga]Ga-Fibroblast Activation Protein Inhibitor (FAPI) PET/CT in Differentiating Malignant and Benign Uptake Findings? [PDF]

Cancers (Basel)
Al-Ibraheem A, Moghrabi S, Alsyouf B, Abdulrahman M, Al-Foqaha M, Al-Tameemi F, Bashabsheh B, Ruzzeh S, Jiad DK, Al-Hammouri AF, Shi H, Abdlkadir AS, Mansour A.   +12 more
europepmc   +1 more source