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Imaging of Fibroblast Activation Protein in the Microenvironment of Tumors by <sup>18</sup>F‑Labeled Positron Emission Tomography Tracers with Increased Polarity. [PDF]
ACS Pharmacol Transl SciKöchel R +5 more
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Fibroblast Activation Protein Inhibitor Theranostics
PET Clinics, 2022The evolution of the fibroblast activation protein inhibitor molecules over the past decade has brought into the forefront a novel theranostic agent that has the potential of matching the workhorse of PET/computed tomography, [fluorine-18] fluoro-2-deoxy-d-glucose (18F-FDG).
Shobhana, Raju +2 more
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Journal of Molecular and Cellular Cardiology, 2015
Fibroblast activation protein α (FAP) is a membrane-bound serine protease expressed by activated fibroblasts during wound healing in the skin. Expression of FAP after myocardial infarction (MI) and potential effects on cardiac wound healing are largely unknown.MI was induced in rats and FAP expression was analyzed at 3, 7 and 28 days post-MI by ...
Paolo Galuppo +2 more
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Fibroblast activation protein α (FAP) is a membrane-bound serine protease expressed by activated fibroblasts during wound healing in the skin. Expression of FAP after myocardial infarction (MI) and potential effects on cardiac wound healing are largely unknown.MI was induced in rats and FAP expression was analyzed at 3, 7 and 28 days post-MI by ...
Paolo Galuppo +2 more
exaly +3 more sources
The Role of Fibroblast Activation Protein in Health and Malignancy
Cancer and Metastasis Reviews, 2020 Fibroblast activation protein-α (FAP) is a type-II transmembrane serine protease expressed almost exclusively to pathological conditions including fibrosis, arthritis, and cancer. Across most cancer types, elevated FAP is associated with worse clinical outcomes.
Louis M Weiner, Allison A Fitzgerald
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Ecto-protein kinase activity of fibroblasts
Archives of Biochemistry and Biophysics, 1979Abstract Isolated, intact dermal fibroblasts can transfer the terminal phosphate of adenosine triphosphate, [γ- 32 P]ATP, to an exogenously added macromolecule (histone). The incorporation of labeled phosphate to histone is attributed to an extracellularly directed protein kinase activity (ecto-kinase) which cannot be accounted for by soluble ...
T M, Chiang, E S, Kang, A H, Kang
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Oral Diseases, 2023
Abstract Objectives Fibroblast activating protein (FAP) is associated with various organ fibrosis. However, the expression and molecular function of FAP in oral submucous fibrosis (OSF) is still unclear. Materials and Methods
Ming Li +6 more
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Abstract Objectives Fibroblast activating protein (FAP) is associated with various organ fibrosis. However, the expression and molecular function of FAP in oral submucous fibrosis (OSF) is still unclear. Materials and Methods
Ming Li +6 more
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Fibroblast Activation Protein in Remodeling Tissues
Current Molecular Medicine, 2012Tissue remodeling is critical during development and wound healing. It also characterizes a number of pathologic conditions, including chronic inflammation, fibrosis and cancer. It is well appreciated that reactive stromal cells play critical roles in these settings.
M, Jacob, L, Chang, E, Puré
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Cardiac Applications of Fibroblast Activation Protein Imaging
PET Clinics, 2023Several promising applications of cardiac molecular fibroblast activation protein (FAP) imaging are emerging. Myocardial fibrosis plays a key role in the complex process of cardiac remodeling and can lead to adverse clinical outcomes such as left ventricular dysfunction, propensity to arrhythmias, and reduction of perfusion.
Johanna, Diekmann, Frank M, Bengel
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