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The Role and Application of Fibroblast Activating Protein
Current Molecular MedicineAbstract: Fibroblast activation protein-α (FAP), a type-II transmembrane serine protease, is rarely expressed in normal tissues but highly abundant in pathological diseases, including fibrosis, arthritis, and cancer. Ever since its discovery, we have deciphered its structure and biological properties and continue to investigate its roles in various ...
Xiao-Lou, Zhang +6 more
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Fibroblast activation protein and chronic liver disease
Frontiers in Bioscience, 2008Fibroblast activation protein (FAP) is the member of Dipeptidyl Peptidase IV (DPIV) gene family that is most similar to DPIV. Four members of this family, DPIV, FAP, DP8 and DP9 possess a rare catalytic activity, hydrolysis of a prolyl bond two residues from the substrate N terminus.
Xin Maggie, Wang +5 more
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Fibroblast Activation Protein Imaging
PET Clinics, 2023Rodney J. Hicks +2 more
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Fibroblast Activation Protein Inhibitor Theranostics
PET Clinics, 2023Kazuko Kaneda-Nakashima +3 more
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Fibroblast activation protein in atherosclerosis and atherothrombosis
2011Heart attacks and strokes currently kill more people every year than cancer and HIV combined. These cardiovascular diseases are caused by atherosclerosis ‐ the formation of so‐called “plaques” in blood vessels. Interestingly, an enzyme called “Fibroblast Activation Protein (FAP)” contributes to arthritis and inflammatory liver disease; both of which ...
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Compounds for inhibition of fibroblast activation protein
2021SIMKOVA ADELA +4 more
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Comprehensive Analysis of Fibroblast Activation Protein Expression in Interstitial Lung Diseases
American Journal of Respiratory and Critical Care Medicine, 2023Jinhe Zhang, Yingying Gu, Yunxin Lai
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