Results 161 to 170 of about 4,897,809 (228)

Integrated Multi‐Time‐Point 18F‐FAPI PET/CT and Immune Histopathology for Predicting Pathological Complete Response in Microsatellite‐Stable Locally Advanced Rectal Cancer Treated With Neoadjuvant Radiotherapy, Chemotherapy, and Immunotherapy

MedComm, Volume 7, Issue 10, October 2026.
Serial multi‐time‐point 18F‐FAPI PET/CT‐derived stromal kinetics and baseline immune‐histopathological features, including iTLS count and B‐cell density, jointly predicted pCR in MSS locally advanced rectal cancer. The resulting four‐variable model achieved a mean nested cross‐validated AUC of 0.874.
Minyi He, Huiting Yang, Yunxing Shi, Rongqin Zhang, Taixuan Wan, Xiaolin Pang, Zhanwen Zhang, Liang Huang   +7 more
wiley   +1 more source

Contemporary Concise Review 2025: Interstitial Lung Disease

Respirology, Volume 31, Issue 10, Page 974-982, October 2026.
ABSTRACT Multidisciplinary discussion remains the cornerstone of ILD diagnosis and management, with recent advances further strengthening the integration of clinical, radiological, pathological, and molecular information. Updated ILD nomenclature and classification better align disease terminology with underlying morphology and pathobiology.
Tonia Magrì, Luca Richeldi
wiley   +1 more source

Sensing‐Integrated Patient‐Derived Tumorspheres Predict Chemotherapeutic Efficacy via Local Extracellular pH Dynamics

Small, Volume 22, Issue 58, 16 October 2026.
The study introduces a 3D sensing‐integrated platform enabling real‐time, non‐invasive monitoring of pH dynamics in patient‐derived PDAC tumorspheres. It revealed distinct extracellular acidification patterns under FOLFIRINOX, gemcitabine, and paclitaxel, correlating with therapeutic efficacy.
Stefania Forciniti, Valentina Onesto, Anna Chiara Siciliano, Helena Iuele, Stefano D'Ugo, Norma Depalma, Cinzia Fasano, Alessandro D'Amuri, Giuseppe Gigli, Marcello G. Spampinato, Loretta L. del Mercato   +10 more
wiley   +1 more source

High expression of fibroblast activation protein (FAP) predicts poor outcome in high-grade serous ovarian cancer. [PDF]

BMC Cancer, 2020
Li M, Cheng X, Rong R, Gao Y, Tang X, Chen Y.   +5 more
europepmc   +1 more source

Fibroblast activation protein (FAP)-mediated promotion of metastasis via the FN1-TGFβ axis and immune suppression in aggressive thyroid cancer. [PDF]

J Transl Med
Udinotti M, Siebolts U, Bauer M, Vaxevanis C, Asiminas A, Lorenz K, Dierks C, Wickenhauser C, Seliger B.   +8 more
europepmc   +1 more source

From Regenerative to Degenerative Niche: Multicellular Crosstalk and Population Dynamics in Skeletal Muscle Aging

Aging Cell, Volume 25, Issue 10, October 2026.
Aging transforms the skeletal muscle microenvironment from a balanced, regenerative niche into a maladaptive, degenerative state. This review highlights how disrupted multicellular crosstalk drives chronic inflammation, fibrosis, and neuromuscular dysfunction, ultimately compromising tissue repair and fueling sarcopenia.
Seongwan Kim, Min Ju Kim, Yong Ryoul Yang   +2 more
wiley   +1 more source

Circulating soluble fibroblast activation protein (FAP) in patients with intra-thoracic cancer undergoing chest radiation. [PDF]

Discov Oncol
Lange T, Renko A, Flierl U, Ademmer FB, Bauersachs J, Christiansen H, Tillmanns J.   +6 more
europepmc   +1 more source

Inhibition of Ornithine Decarboxylase 1 Mitigates Denervation‐Induced Muscle Atrophy by Suppressing Proteolysis and Preserving Muscle Stem Cell Homeostasis

Cell Proliferation, Volume 59, Issue 10, October 2026.
Polyamine metabolism is innervation responsive and involved in denervation‐induced muscle atrophy. Inhibition of polyamine metabolism attenuates muscle atrophy by restraining proteolysis and preserving MuSCs homeostasis. Denervation‐induced activation of FAP‐derived FGF7 drives premature MuSCs activation, while DFMO suppresses this paracrine cue to ...
Mingming Zhang, Feifan Chang, Siliang Ge, Fuming Cao, Pincong Fu, Haobo Zhang, Ming Chen, Yi Li, Peifu Tang, Pengbin Yin   +9 more
wiley   +1 more source

Revolutionizing Solid Tumor Surgery with Fibroblast Activation Protein (FAP)-Targeted Imaging Probes for a Fluorescence-Guided Surgery of Pancreatic Cancer. [PDF]

Bioconjug Chem
Ma H, de Muynck LDAN, Houvast RD, Beekman S, Piet A, March TL, Hawinkels LJAC, Mieog JSD, Vahrmeijer AL, Seimbille Y.   +9 more
europepmc   +1 more source

Cystic Fibrosis and Colorectal Cancer Risk: Reprogramming of the Intestinal Epithelial Niche and Cell‐State Plasticity in the CFTR Modulator Era

Cell Proliferation, Volume 59, Issue 10, October 2026.
In cystic fibrosis disorder, CFTR dysfunction drives multilayered intestinal niche disruption, including dysbiosis, inflammation, hypoxia, metabolic stress and genotoxic injury, promoting cell‐state plasticity and a pre‐neoplastic ecosystem. CFTR modulators and environmental factors may partially reshape these processes, highlighting opportunities for ...
Bala Umashankar, Ines Pankonien, Margarida Amaral, Chee Y. Ooi, Thierry Jardé, Shafagh A. Waters   +5 more
wiley   +1 more source