Results 141 to 150 of about 4,897,809 (228)

LAM nodules express fibroblast markers.

, 2015
LAM nodules react with antibodies against alpha-Smooth Muscle Actin, Fibroblast Surface Protein (FSP), Fibroblast Activation Protein (FAP) and S100A4.
Arundhati Dongre (529194), Vera P. Krymskaya (188111), Simon R. Johnson (529197), Debbie Clements (529193)   +3 more
core   +1 more source

Integrated scRNA‐Seq and Spatial Transcriptomics Reveal CHPF and GPC1 as Markers of Cancer‐Associated Fibroblast–Dominant Domains in Colorectal Cancer

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Spatial heterogeneity in the colorectal cancer (CRC) tumor microenvironment (TME) is closely related to stromal organization and may influence treatment‐related features. In this study, we integrated single‐cell RNA sequencing and spatial transcriptomic data from CRC tissues to examine cancer‐associated fibroblast (CAF)‐dominant spatial ...
Yuan‐jie Liu, Qian‐wen Ye, Hui Zhang, Ning Yang, Yang Li, Jie‐pin Li   +5 more
wiley   +1 more source

Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP)

, 2014
: Fibroblast activation protein (FAP) is a serine protease related to dipeptidyl peptidase IV (DPPIV). It has been convincingly linked to multiple disease states involving remodeling of the extracellular matrix.
Heirbaut, Leen, Joossens, Jurgen, Maes, Louis, Cos, Paul, De Meester, Ingrid, Lambeir, Anne-Marie, van der Veken, Pieter, Verkerk, Robert, Jansen, Koen, Cheng, Jonathan D., Augustyns, Koen   +10 more
core   +1 more source

Expression of COL6A1 in Tumor Matrix of Cholangiocarcinoma and Its Mechanism of Tumor Progression

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Cholangiocarcinoma (CCA), a malignant tumor originating from the bile duct epithelial cells, is characterized by aggressive invasion and poor prognosis. Abnormal remodeling of the tumor microenvironment plays a pivotal role in its disease progression.
Weibin Zhang, Chongshi Gao, Chongzhou Lan, Jia Dong, Boxing Xu, Yingmei Li, Jin Dai, Baitong Che, Cheng Li, Gang Dong, Yunfei Wu, Bo Li, Cheng Yang, Lingmei Kong   +13 more
wiley   +1 more source

PEGylated black-phosphorus nanosheet–alginate hydrogels enable local PRRX1 delivery to drive fibroblast reprogramming in intestinal fibrosis

Journal of Nanobiotechnology
Intestinal fibrosis drives stricturing complications in Crohn’s disease (CD), yet the core stromal regulators remain incompletely defined. Here, we profile paired fibrotic and non-fibrotic ileum from CD patients using single-cell RNA sequencing and ...
Yidong Chen, Jiamin Li, Junrong Li, Xiaopeng Zhang, Fang Liu, Qi Yu, Liangru Zhu   +6 more
doaj   +1 more source

Extended Structure–Activity Relationship and Pharmacokinetic Investigation of (4-Quinolinoyl)glycyl-2-cyanopyrrolidine Inhibitors of Fibroblast Activation Protein (FAP)

, 2016
Fibroblast activation protein (FAP) is a serine protease related to dipeptidyl peptidase IV (DPPIV). It has been convincingly linked to multiple disease states involving remodeling of the extracellular matrix.
Jonathan D. Cheng (1822102), Leen Heirbaut (1822099), Jurgen Joossens (1403128), Paul Cos (233137), Ingrid De Meester (823111), Pieter Van der Veken (713741), Koen Augustyns (713742), Anne-Marie Lambeir (328419), Robert Verkerk (394953), Koen Jansen (1822096), Louis Maes (191127)   +10 more
core   +1 more source

Microbiome and Tumor Microenvironment Interactions: Advances From Ecological Niches to Precision Oncology

Cancer Nexus, Volume 2, Issue 4, October 2026.
Tumor‐associated microbiota occupies spatially organized ecological niches and influence cancer progression by reshaping tumor‐cell signaling, metabolism, immunity, stromal remodeling, and therapeutic response. Integrating microbiome‐derived biomarkers, targeted microbial interventions, spatial multi‐omics, longitudinal monitoring, and AI may enable ...
Yiwen Zhang, Ji'an Liu, Jing Li, Xue Liu, Yang Su, Peng Luo, Yuhan Zhang, Zhengrui Li   +7 more
wiley   +1 more source

Preparation of Extracellular Matrices and Cell/Matrix Functional Units Produced by Cultured and Primary Fibroblasts

Current Protocols, Volume 6, Issue 10, October 2026.
Abstract Fibroblast‐derived matrices (FDMs) provide a biologically relevant in vitro alternative to conventional two‐dimensional (2D) substrates by enabling fibroblasts to assemble and organize their own extracellular matrix (ECM) environment, closely mimicking the physiological stromal microenvironment.
Aleksandr Dolskii, Janusz Franco‐Barraza, Mariia Dmitrieva, Tiffany Luong, Olivia C. Williams, Sérgio A. Alcantara dos Santos, Yash Chhabra, Brooke A. Pereira, Michael Miano, Julia Hoopman, Lu Chen, Caneta Brown, Edna Cukierman   +12 more
wiley   +1 more source

CLDN18.2 in pancreatic ductal adenocarcinoma: Biomarker assessment, spatial heterogeneity and therapeutic modality selection

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review presents a framework for selecting Claudin 18.2 (CLDN18.2)‐directed treatment modalities in pancreatic ductal adenocarcinoma according to tumour antigen coverage and spatial distribution. Representative assessment at baseline and reassessment after progression can guide treatment adaptation over time.
Ruyu Tan, Zhexin Zhang, Jiaxin Wang, Roland Andersson, Daniel Ansari, Jinfei Chen   +5 more
wiley   +1 more source

Fibro‐Adipogenic Progenitor Ablation Triggers Muscle Atrophy Through Cell Death‐Induced Inflammation

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Skeletal muscle mass maintenance involves coordination of myofibers with mononuclear cell populations, including satellite cells, resident macrophages and fibro‐adipogenic progenitors (FAPs). FAPs, identified by surface expression of PDGFRα, are important contributors to muscle homeostasis, as genetic ablation of FAPs induces rapid ...
Yangyi E. Luo, Young il Lee, Zoe Abe‐Teh, Rachel Y. Young, Lan Wei‐LaPierre, Elisabeth R. Barton   +5 more
wiley   +1 more source