Results 121 to 130 of about 4,897,809 (228)

Time‐Dependent Efficacy of Lymphaticovenous Anastomosis in Secondary Lymphedema: A Rabbit Model Study

open access: yesThe FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Secondary lymphedema was induced in New Zealand White rabbits by popliteal lymph node excision and afferent lymphatic vessel ligation, causing sustained hind limb swelling. LVA was performed immediately or after 4, 8, or 12 weeks. Patency was verified intraoperatively by microsuturing and postoperatively by indocyanine green (ICG) lymphangiography ...
Ping Zhao   +5 more
wiley   +1 more source

Derajat Ekspresi Fibroblast Activation Protein Pada Cancer-Associated Fibroblast Karsinoma Kolorektal

open access: yesMajalah Kedokteran Andalas
Objective: to determine the degree of expression of Fibroblast Activation Protein in Cancer Associated Fibroblasts of colorectal carcinoma. Methods: descriptive study with a cross sectional research design.
Vonny Amalia
doaj   +1 more source

Fibro‐Adipogenic Progenitors From Skeletal Muscle Enhance Microvascular Angiogenesis in a 3D Model

open access: yesAdvanced Biology, Volume 10, Issue 10, October 2026.
Fibro‐adipogenic progenitors (FAPs) are skeletal muscle stem cells that reside between fibers and near capillaries. However, relatively few studies have investigated interactions between FAPs and the microvasculature. We demonstrate that FAPs enhance angiogenesis of microvascular fragments (MVFs) by promoting increases in vessel percentage area and ...
Christian M. Mendiondo   +6 more
wiley   +1 more source

Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 39, 23 October 2026.
Three‐dimensional bioprinting transforms breast cancer modeling from simple constructs into spatially organized, multicellular, perfused, and patient‐derived platforms. This review shows how bioinks, cellular composition, architecture, and flow govern tumor behavior and drug response, while revealing why complexity alone is insufficient without ...
Mustafa Nakipoglu   +7 more
wiley   +1 more source

Fibroblast activation protein and the tumour microenvironment: challenges and therapeutic opportunities

open access: yesOncology Reviews
Fibroblast Activation Protein (FAP) has emerged as a critical player in cancer biology, particularly in shaping the tumour microenvironment (TME) and influencing immunotherapy outcomes.
Hsing Hwa Lee, Zeyad Al-Ogaili
doaj   +1 more source

Cyclic Mechanical Loading of Cardiomyocytes via Pressure‐Driven Non‐Planar Membrane Deformation in a Bioreactor System

open access: yesAdvanced Science, Volume 13, Issue 55, 5 October 2026.
In this research article, Mansoor and coworkers present a novel device that applies controlled mechanical stimuli to cardiomyocytes using pressure‐driven membrane deformation. By exposing cells to physiologically and pathologically relevant loading conditions, the platform reproduces distinct structural, functional and molecular responses associated ...
Haris Mansoor   +11 more
wiley   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

open access: yesAdvanced Science, Volume 13, Issue 55, 5 October 2026.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang   +19 more
wiley   +1 more source

A review of the development and research progress of FAPI PET probes

open access: yes肿瘤影像学
The application of fibroblast activation protein (FAP) in cancer-associated fibroblast (CAF) has garnered widespread attention in nuclear medicine. FAP is highly expressed in most cancer tissues and rarely expressed in healthy tissues.
CHENG Hua, BAI Liyan, SONG Shaoli
doaj  

Protein-based Radiopharmaceuticals that target fibroblast activation protein alpha: a review of current progress

open access: yesEJNMMI Radiopharmacy and Chemistry
Background Fibroblast activation protein alpha (FAP) is a serine protease that is expressed at basal levels in benign tissues but is overexpressed in a variety of pathologies, including cancer.
Abdelrahman Homedan   +3 more
doaj   +1 more source

Synthesis, radiolabeling, and evaluation of a (4-quinolinoyl)glycyl-2-cyanopyrrolidine analogue for fibroblast activation protein (FAP) PET imaging. [PDF]

open access: yesFront Bioeng Biotechnol, 2023
Zhang N   +10 more
europepmc   +1 more source

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