Results 131 to 140 of about 4,897,809 (228)

Fibroblast activation protein is induced by inflammation and degrades type I collagen in thin-cap fibroatheromata [PDF]

, 2017
Aims Collagen degradation in atherosclerotic plaques with thin fibrous caps renders them more prone to rupture. Fibroblast activation protein (FAP) plays a role in arthritis and tumour formation through its collagenase activity. However, the significance
Graves, Kirk, Lüscher, Thomas F., Renner, Christoph, Genoni, Michele, Richards, Peter, Aikawa, Elena, Hoerstrup, Simon P., Winnik, Stephan, Matter, Christian M., Vogt, Peter, Brokopp, Chad E., Weber, Benedikt, Lohmann, Christine, Bauer, Stefan, Schoenauer, Roman, Emmert, Maximilian Y.   +15 more
core  

Modulating Calcium Homeostasis via a Biomimetic Scaffold to Rescue Diabetic Ischemic Wounds

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This strategy addresses impaired microcirculation and loss of extracellular matrix (ECM) guidance in diabetic wound healing. Musc@CP, a nanofibrous dressing combining an ECM‐mimetic chitosan‐pullulan scaffold with muscone, enhances perfusion by attenuating intracellular Ca2+ overload‐associated endothelial dysfunction.
Xiang Zheng, Mingmei Li, Jianjun Jiang, Yongchao Wang, Yaru Jia, Weilun Sun, Yi Yao, Pengli Gao, Linhua Zhang, Qi Guo, Guang Jia, Xing‐Jie Liang, Dunwan Zhu, Jinchao Zhang, Fangzhou Li   +14 more
wiley   +1 more source

T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li, Junting Guan, Yifan Song, Hongxia Yang, Guangtao Li, Xiaodong Zhao, Jiaxin Liu, Bin Liu, Yang Tan, Honglan Zhou, Yang‐He Zhang, Yishu Wang   +11 more
wiley   +1 more source

Design, Synthesis and Preclinical Assessment of ^99mTc-iFAP for In Vivo Fibroblast Activation Protein (FAP) Imaging. [PDF]

Molecules, 2022
Trujillo-Benítez D, Luna-Gutiérrez M, Ferro-Flores G, Ocampo-García B, Santos-Cuevas C, Bravo-Villegas G, Morales-Ávila E, Cruz-Nova P, Díaz-Nieto L, García-Quiroz J, Azorín-Vega E, Rosato A, Meléndez-Alafort L.   +12 more
europepmc   +1 more source

In Situ Self‐Assembled Molecular Fortifying Agent for Enhanced Retention and Therapeutic Efficacy of Radiopharmaceuticals

Aggregate, Volume 7, Issue 10, October 2026.
A molecular‐fortifying agent strategy based on in situ self‐assembly is developed to prolong tumor retention of radioligands. After tumor‐targeting, FAP‐α cleavage triggers nanofiber formation, presenting azide anchors for bioorthogonal capture of pre‐accumulated radioligands.
Daojia Liu, Xiaoqin Luo, Xiaojuan Wang, Xing Liu, Fanglei Zhang, Pan Wang, Jibin Song, Junqiang Chen   +7 more
wiley   +1 more source

FAP-Anchored Retinoic Acid Nanoparticles for Stromal Reprogramming and Enhanced Intratumoral Oxaliplatin Delivery in Fibrotic Colorectal Tumours

Biosensors
In colorectal cancer (CRC), cancer-associated fibroblasts (CAFs) and the fibrotic stroma generate form a dense stromal barrier that restricts the intratumoural exposure and spatial distribution of oxaliplatin.
Haixia Wang, Can Xu, Ling Xie, Xiaohe Chu, Xinyu Liu, Peng Wang   +5 more
doaj   +1 more source

Translational imaging of the fibroblast activation protein (FAP) using the new ligand [⁶⁸Ga]Ga-OncoFAP-DOTAGA. [PDF]

Eur J Nucl Med Mol Imaging, 2022
Backhaus P, Gierse F, Burg MC, Büther F, Asmus I, Dorten P, Cufe J, Roll W, Neri D, Cazzamalli S, Millul J, Mock J, Galbiati A, Zana A, Schäfers KP, Hermann S, Weckesser M, Tio J, Wagner S, Breyholz HJ, Schäfers M.   +20 more
europepmc   +1 more source

Fibroblast activation protein (FAP) [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

Integrated Spatial and Bulk Transcriptomic Analysis Identifies a Multicellular Ecosystem Involved in Progression of Young Breast Cancer

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Young breast cancer (YBC), defined as diagnosis at or before the age of 40 years, is characterized by an aggressive phenotype and poor prognosis. The tumor microenvironment (TME), comprising immune and stromal cells, plays a critical role in tumor initiation and progression and is closely associated with clinical outcomes. However, alterations
Xiaolin Chen, Zhuozhi Liang, Xinming Chen, Qian Ouyang, Qianru Chen, Liling Zhu, Shunrong Li, Kai Chen   +7 more
wiley   +1 more source

Investigation of FAP (Fibroblast Activation Protein) in Thymic Epithelial Tumors

Thymic epithelial tumors (TETs), encompassing thymomas and thymic carcinomas, are rare neoplasms with diverse clinical behaviors, posing challenges in prognosis prediction and treatment. This study investigates the role of cancer-associated fibroblasts (CAFs) and Fibroblast Activation Protein (FAP) in TET progression.
openaire   +1 more source