Results 111 to 120 of about 4,897,809 (228)

Scaling temporal resolution from mice to humans: Challenges and innovations in preclinical imaging of translational models

The Journal of Physiology, EarlyView.
Abstract figure legend Temporal scaling physiology differs significantly between mice and humans. Mice have higher metabolism, heart and respiratory rate, as well as faster blood flow rates, brain activity and physiological dynamics over time. These differences influence the temporal resolution needed in preclinical imaging of mouse models to ...
Sara Gargiulo, Matteo Gramanzini
wiley   +1 more source

Prognostic impact of discordant lesions on [18F]FDG and [68Ga]Ga-FAPI-04 PET/CT compared to histological FAP expression in neuroendocrine neoplasms

Frontiers in Nuclear Medicine
ObjectiveOn dual-tracer positron emission tomography/computed tomography (PET/CT) with 2-deoxy-2-[¹⁸F]fluoro-D-glucose ([¹⁸F]FDG) and fibroblast activation protein inhibitor ([⁶⁸Ga]Ga-FAPI-04), discordant lesions (FDG+/FAPI-) in aggressive neuroendocrine
Tim Jedamzik, Aleksander Kosmala, Stefan Kircher, Marieke Heinrich, Wiebke Schlötelburg, Andreas K. Buck, Alexander Meining, Alexander Meining, Rudolf A. Werner, Rudolf A. Werner, Rudolf A. Werner, Alexander Weich, Alexander Weich, Kerstin Michalski   +13 more
doaj   +1 more source

Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

The Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo, Haoyan Han, Michael O'Dwyer, Eileen Reidy, Aideen E. Ryan   +4 more
wiley   +1 more source

Fibroblast activation protein (FAP) [PDF]

Science-Business eXchange, 2013
openaire   +2 more sources

Increased perivascular fibrosis and pro-fibrotic cellular transition in intramyocardial blood vessels in myocardial infarction patients

Journal of Molecular and Cellular Cardiology Plus
Background and objectives: Structural and functional changes in the intramyocardial microcirculation increase the risk of myocardial infarction (MI). This study investigated intramyocardial perivascular fibrosis and pro-fibrotic cellular transitions in ...
Zhu Jiang, Giulia Sorrentino, Suat Simsek, Joris J.T.H. Roelofs, Hans W.M. Niessen, Paul A.J. Krijnen   +5 more
doaj   +1 more source

New therapeutic options for metabolic‐associated steatotic liver disease

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3770-3777, November 2026.
An increasing number of patients are being diagnosed with metabolic dysfunction‐associated steatotic liver disease (MASLD). MASLD results from disturbances in hepatic lipid metabolism and is associated with an increased risk of cirrhosis and hepatocellular carcinoma and significant extrahepatic morbidity, including cardiovascular disease and ...
Tessa Straatmijer, Midas Mulder
wiley   +1 more source

Fibroblast activation protein (FAP)-targeted radionuclide therapy: which ligand is the best? [PDF]

Eur J Nucl Med Mol Imaging, 2023
Chakravarty R, Song W, Chakraborty S, Cai W.   +3 more
europepmc   +1 more source

Prognostic Value of LINC01140 in Colorectal Cancer and Its Regulatory Effect on Chemotherapy Resistance via miR‐942‐5p/NRXN1

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
Targeting the LINC01140/miR‐942‐5p/NRXN1 axis may be able to inhibit CRC progression by simultaneously regulating the functions of tumor cells and CAFs, which might significantly enhance the clinical efficacy of targeted therapy. ABSTRACT Long non‐coding RNAs play a wide role in colorectal cancer (CRC).
Jian Zhao, Songjie Liu, Bing Xu
wiley   +1 more source

Based on small molecules: development and application of fibroblast activation protein inhibitors radiopharmaceutical in tumor precision therapy

Frontiers in Pharmacology
The discovery of biomarkers for malignant tumors is driving the development of new radiopharmaceuticals in nuclear medicine. The development and optimization of novel radiopharmaceuticals to occupy an increasingly important role in tumor diagnosis and ...
Yihui Luo, Haitian Fu, Haitian Fu, Chunjing Yu, Chunjing Yu   +4 more
doaj   +1 more source

Ocular Manifestations of Infectious Salmon Anaemia Virus Infection in Atlantic Salmon (Salmo salar)

Journal of Fish Diseases, Volume 49, Issue 11, November 2026.
ABSTRACT Eyes are essential sensory organs needed by teleost Atlantic salmon for high visual acuity and survival in both the wild and in aquaculture settings. In this work, we assessed the ocular manifestations of Infectious Salmon Anaemia Virus (ISAV) infection in Atlantic salmon by a cohabitation‐mediated infection assay and histological and ...
Emily Mahon, Rebecca R. Kwabiah, Hélène Paradis, Manuel A. Soto‐Dávila, Sathees Duglas, Raja Ram Gurung, Thurka Paramanathan, Ignacio Vasquez, Shams Al‐Badoosh, John Law, Javier Santander, Mark D. Fast, Robert L. Gendron   +12 more
wiley   +1 more source