Fibroblast activation protein fap

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Understanding fibroblast activation protein (FAP): Substrates, activities, expression and targeting for cancer therapy

PROTEOMICS – Clinical Applications, 2014
Fibroblast activation protein (FAP) is best known for its heightened expression in tumour stroma. This atypical serine protease has both dipeptidyl peptidase and endopeptidase activities, cleaving substrates at a post‐proline bond. FAP expression is difficult to detect in non‐diseased adult organs, but is greatly upregulated in sites of tissue ...
Hamson, Elizabeth J. +4 more
openaire +3 more sources

Abstract 4287: Serological quantification of fibroblast activation protein (FAP) cleaved type III collagen: A biomarker for FAP activity

Cancer Research
Abstract Introduction: Fibroblast activation protein (FAP) has unique proteolytic activity with very low expression in healthy tissues, while being upregulated in diseased tissues including many types of cancer for example non-small cell lung cancer (NSCLC). The disease specific expression and unique proteolytic activity have made FAP an
Rasmus Sund Pedersen, Morten Karsdal, Nicholas Willumsen +2 more
openaire +1 more source

Targeting fibroblast activation protein (FAP): advances in CAR-T cell, antibody, and vaccine in cancer immunotherapy

Drug Delivery and Translational Research, 2023
Leila Arabi
exaly

Fibroblast Activation Protein Alpha (FAPα) in Fibrosis: Beyond a Perspective Marker for Activated Stromal Cells?

Biomolecules, 2023
Maria Kulebyakina, Anastasia Efimenko, Nataliya Basalova +2 more
exaly

Design, Synthesis and Preclinical Assessment of 99mTc-iFAP for In Vivo Fibroblast Activation Protein (FAP) Imaging

Molecules, 2022
Clara L Santos-Cuevas +2 more
exaly

A Protective Role For Fibroblast Activation Protein (FAP) In Pulmonary Fibrosis