Results 131 to 140 of about 5,296,642 (245)

[68Ga]Ga-labeled fibroblast activation protein inhibitor PET/CT for monitoring neoadjuvant chemotherapy responses in breast cancer subtypes

Breast Cancer Research
Background [68Ga]Ga-labeled fibroblast activation protein inhibitor ([68Ga]Ga-FAPI) PET/CT has shown promising potential in predicting pathological complete response (pCR) in patients with breast cancer (BC).
Ling Chen, Lingjun Kong, Jiaqi Yang, Jiajie Xue, Shan Zheng, Linying Chen, Sunwang Xu, Xiangjin Chen, Youzhi Zhu   +8 more
doaj   +1 more source

Human iPSC‐Derived Tissue‐Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model

Advanced Healthcare Materials, EarlyView.
Inspired by conventional cell therapy and emerging bioengineering approaches, the tissue‐engineered nigrostriatal pathway (TE‐NSP) has an anatomically‐inspired design comprising a population of human dopaminergic neurons with unidirectional, long‐projecting axon tracts.
Wisberty J. Gordián‐Vélez, Dimple Chouhan, Kevin D. Browne, James Lim, Saarang P. Karandikar, Rodrigo A. España, John E. Duda, H. Isaac Chen, D. Kacy Cullen   +8 more
wiley   +1 more source

Macrophage–Fibroblast Crosstalk Governs Tumor Mechanics, as Revealed by Spatiotemporal Force Mapping in 3D Spheroids

Advanced Healthcare Materials, EarlyView.
This study shows crosstalk among tumor cells, fibroblasts, and macrophages alters the physical forces inside 3D tumor spheroids. Incorporating deformable microparticles in 3D tumor spheroids, the researchers mapped mechanical stresses spatially and with respect to tumor growth (temporally).
Kunal P. Pednekar, Daan Vorselen, Jai Prakash   +2 more
wiley   +1 more source

A novel fibroblast activation protein-targeted near-infrared fluorescent off-on probe for cancer cell detection, &ITin vitro&IT and &ITin vivo &ITimaging

, 2018
A new hemicyanine-based fibroblast activation protein-targeted near-infrared fluorescent probe is designed and it shows high selectivity and sensitivity to cancer cell detection, and in vitro and in vivo imaging.
Xiang, Lingchao, Li, Zihou, Xing, Jie, Xia, Yuanzhi, Wu, Aiguo, Yu, Zhangsen, Ye, Yufan, Zou, Ruifen, Gong, Qiuyu   +8 more
core  

LDLs induce fibroblast spreading independently of the LDL receptor via activation of the p38 MAPK pathway

, 2003
Because adventitial fibroblasts play an important role in the repair of blood vessels, we assessed whether elevation in LDL concentrations would affect fibroblast function and whether this depended on activation of intracellular signaling pathways.
Dobreva, I., Widmann, C., Christian Widmann, Gérard Waeber, Richard W. James, Mooser, V., Iveta Dobreva, Vincent Mooser, Waeber, G., James, R.W., Waeber G, Mooser V, James RW, Widmann C, Dobreva I   +14 more
core   +1 more source

The Role of Viscoelasticity in Heterogeneous Glioblastoma Stem Cell Invasion in Biomimetic 3‐Dimensional Hydrogels

Advanced Healthcare Materials, EarlyView.
The role of viscoelasticity in the invasion of heterogeneous glioblastoma stem cells (GSCs) was investigated with GSCs categorized into subgroups based on molecular profile, as Reactive, Invasive, or Constructive using viscoelastic biomimetic hyaluronan‐oxime hydrogels.
Nicole J. Blaine, Arianna Skirzynska, Allysia A. Chin, Julie Audet, Molly S. Shoichet   +4 more
wiley   +1 more source

Radiolabeled fibroblast activation protein inhibitors in the evaluation of myocardial fibrosis

Chinese Medical Journal, 2023
Xiangyu Su, Yiheng Zhao, Xiang Zhou, Peifang Wei   +3 more
openaire   +3 more sources

Mechanoactive Biomaterials for Cell–Matrix Mechanotransduction

Advanced Materials, EarlyView.
The graphical abstract shows how individual triggers (force, light, or temperature) and combined optothermal or receptor‐targeted actuation induce material responses at the tissue, cellular, and receptor scales. Their spatial (global or focused) and temporal (continuous or cyclic) modulation determines the resulting mechanical output.
Yi‐Tung Lu, Alison E. John, Marc A. Fernández‐Yagüe   +2 more
wiley   +1 more source

Dihydroartemisinin alleviates pulmonary fibrosis by modulating the calcium signaling pathway in fibroblasts

Journal of Translational Medicine
Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, irreversible interstitial lung disease with limited effective treatment options.
Caihong Luo, Zhansheng Zou, Zili Zhou, Cuiwen Wu, Yuanhao Wei, Xujing Luo, Qingmei Wang, Li Jiang, Yiming You, Shaoxi Cai, Changhui Yu   +10 more
doaj   +1 more source

Vitamin C‐Induced Photo‐Redox Threshold Enables High‐Fidelity Volumetric Printing of Collagen

Advanced Materials, EarlyView.
Tomographic volumetric printing (TVP) of native proteins is limited by uncontrolled background crosslinking. Here, vitamin C is introduced as a biocompatible redox regulator to establish a tunable nonlinear polymerization threshold response for TVP.
Bin Wang, Amelia Hasenauer, Kristian Ivkovic, Ann‐Sophie Frind, David Fercher, Marcy Zenobi‐Wong   +5 more
wiley   +1 more source