Results 31 to 40 of about 307,105 (254)

Fibroblast Growth Factor-2 Signaling in Neurogenesis and Neurodegeneration [PDF]

Journal of Neuroimmune Pharmacology, 2013
Fibroblast growth factor-2 (FGF2), also known as basic FGF, is a multi-functional growth factor. One of the 22-member FGF family, it signals through receptor tyrosine kinases encoding FGFR1-4. FGF2 activates FGFRs in cooperation with heparin or heparin sulfate proteoglycan to induce its pleiotropic effects in different tissues and organs, which include
Maya E, Woodbury, Tsuneya, Ikezu
openaire   +2 more sources

Fibroblast growth factor 2 orchestrates angiogenic networking in non-GIST STS patients

Journal of Translational Medicine, 2011
Background Non-gastrointestinal stromal tumor soft-tissue sarcomas (non-GIST STSs) constitute a heterogeneous group of tumors with poor prognosis. Fibroblast growth factor 2 (FGF2) and fibroblast growth factor receptor-1 (FGFR-1), in close interplay with
Smeland Eivind, Sorbye Sveinung W, Valkov Andrej, Kilvaer Thomas K, Bremnes Roy M, Busund Lill-Tove, Donnem Tom   +6 more
doaj   +1 more source

Gait disturbances and muscle dysfunction in fibroblast growth factor 2 knockout mice

Scientific Reports, 2021
Fibroblast growth factor 2 (FGF2) is important in musculoskeletal homeostasis, therefore the impact of reduction or Fgf2 knockout on skeletal muscle function and phenotype was determined.
C. Homer-Bouthiette, L. Xiao, Marja M. Hurley   +2 more
doaj   +1 more source

Fibroblast growth factor-2 mediates pressure-induced hypertrophic response [PDF]

Journal of Clinical Investigation, 1999
In vitro, fibroblast growth factor-2 (FGF2) has been implicated in cardiomyocyte growth and reexpression of fetal contractile genes, both markers of hypertrophy. However, its in vivo role in cardiac hypertrophy during pressure overload is not well characterized.
J E, Schultz, S A, Witt, M L, Nieman, P J, Reiser, S J, Engle, M, Zhou, S A, Pawlowski, J N, Lorenz, T R, Kimball, T, Doetschman   +9 more
openaire   +2 more sources

Essential growth factor receptors for fibroblast homeostasis and activation: Fibroblast Growth Factor Receptor (FGFR), Platelet Derived Growth Factor Receptor (PDGFR), and Transforming Growth Factor β Receptor (TGFβR) [version 2; peer review: 2 approved]

F1000Research
Fibroblasts are cells of mesenchymal origin that are found throughout the body. While these cells have several functions, their integral roles include maintaining tissue architecture through the production of key extracellular matrix components, and ...
Matthew B. Buechler, Maye F. Cheng, Faizah S. Abdullah   +2 more
doaj   +1 more source

Fibroblast growth factor-2 alters the nature of extinction [PDF]

Learning & Memory, 2011
These experiments examined the effects of the NMDA-receptor (NMDAr) antagonist MK801 on reacquisition and re-extinction of a conditioned fear that had been previously extinguished before injection of fibroblast growth factor-2 (FGF2) or vehicle. Recent findings have shown that relearning and re-extinction, unlike initial learning and extinction, do not
Bronwyn M, Graham, Rick, Richardson
openaire   +2 more sources

Topical fibroblast growth factor‐2 for treatment of chronic tympanic membrane perforations

Laryngoscope Investigative Otolaryngology, 2020
Objective To determine the efficacy of fibroblast growth factor‐2 (FGF‐2) in treating chronic nonhealing tympanic membrane (TM) perforations. Method Double‐blinded, randomized placebo controlled phase 2 clinical trial for patients with chronic TM ...
Felipe Santos, Edina Shu, Daniel J. Lee, David H. Jung, Alicia M. Quesnel, Konstantina M. Stankovic, Dunia E. Abdul‐Aziz, Camden P. Bay, Amy Quinkert, D. Bradley Welling   +9 more
doaj   +1 more source

Fibroblast Growth Factor 2 Augments Transforming Growth Factor Beta 1 Induced Epithelial-mesenchymal Transition in Lung Cell Culture Model

Iranian Journal of Allergy, Asthma and Immunology, 2020
Impaired lung epithelial cell regeneration following injury may contribute to the development of pulmonary fibrosis. Epithelial-mesenchymal transition (EMT) is a critical event in embryonic development, wound healing following injury, and even cancer ...
Lamis M.F. El-Baz, Nahla M. Shoukry, Hani S. Hafez, Robert D. Guzy, Mohamed Labib Salem   +4 more
doaj   +1 more source

Combined therapy of platelet-rich plasma and basic fibroblast growth factor using gelatin-hydrogel sheet for rotator cuff healing in rat models

Journal of Orthopaedic Surgery and Research, 2021
Introduction Excellent outcomes of arthroscopic rotator cuff repair for small and medium tears have been recently reported. However, re-tears after surgery have been a common complication after surgical repair of large and massive rotator cuff tears and ...
Takeshi Kataoka, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Takashi Kurosawa, Kohei Yamaura, Shintaro Mukohara, Takehiko Matsushita, Takahiro Niikura, Yasuhiko Tabata, Ryosuke Kuroda   +10 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source