Results 1 to 10 of about 8,552 (153)

Role of Fibroblast Growth Factor 23 (FGF23) and αKlotho in Cancer [PDF]

Frontiers in Cell and Developmental Biology, 2021
Together with fibroblast growth factors (FGFs) 19 and 21, FGF23 is an endocrine member of the family of FGFs. Mainly secreted by bone cells, FGF23 acts as a hormone on the kidney, stimulating phosphate excretion and suppressing formation of 1,25(OH)2D3 ...
Franz Ewendt, Martina Feger, Michael Föller   +2 more
doaj   +5 more sources

PKC regulates the production of fibroblast growth factor 23 (FGF23). [PDF]

PLoS ONE, 2019
Serine/threonine protein kinase C (PKC) is activated by diacylglycerol that is released from membrane lipids by phospholipase C in response to activation of G protein-coupled receptors or receptor tyrosine kinases.
Ludmilla Bär, Philipp Hase, Michael Föller   +2 more
doaj   +5 more sources

Variation in the fibroblast growth factor 23 (FGF23) gene associates with serum FGF23 and bone strength in infants [PDF]

Frontiers in Genetics, 2023
Introduction: The effects of genetic variation in fibroblast growth factor 23 (FGF23) are unclear. This study explores the associations of single-nucleotide polymorphisms (SNPs) of FGF23 with phosphate and vitamin D metabolism and bone strength in early ...
Maria Enlund-Cerullo, Maria Enlund-Cerullo, Maria Enlund-Cerullo, Elisa Holmlund-Suila, Elisa Holmlund-Suila, Saara Valkama, Saara Valkama, Helena Hauta-alus, Helena Hauta-alus, Helena Hauta-alus, Helena Hauta-alus, Jenni Rosendahl, Jenni Rosendahl, Sture Andersson, Minna Pekkinen, Minna Pekkinen, Minna Pekkinen, Outi Mäkitie, Outi Mäkitie, Outi Mäkitie, Outi Mäkitie   +20 more
doaj   +6 more sources

Ectopic expression of Klotho in fibroblast growth factor 23 (FGF23)-producing tumors that cause tumor-induced rickets/osteomalacia (TIO) [PDF]

Bone Reports, 2019
Tumor-induced rickets/osteomalacia (TIO) is a rare paraneoplastic syndrome caused by tumors that ectopically express fibroblast growth factor 23 (FGF23). FGF23 is a bone-derived hormone that regulates serum phosphate concentrations.
Yuka Kinoshita, Yuichi Takashi, Nobuaki Ito, Shiro Ikegawa, Hiroyuki Mano, Tetsuo Ushiku, Masashi Fukayama, Masaomi Nangaku, Seiji Fukumoto   +8 more
doaj   +4 more sources

Oncostatin M is a regulator of fibroblast growth factor 23 (FGF23) in UMR106 osteoblast-like cells [PDF]

Scientific Reports, 2023
Renal phosphate and vitamin D metabolism is under the control of fibroblast growth factor 23 (FGF23), an endocrine and paracrine factor predominantly produced in bone. FGF23 formation is stimulated by active vitamin D, or parathyroid hormone (PTH), which
Sina Münz, Martina Feger, Michael Föller   +2 more
doaj   +4 more sources

Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation. [PDF]

J Biol Chem, 2023
ABSTRACT Fibroblast growth factor-23 (FGF23) is a bone-derived hormone that has recently received much attention due to its association with the progression of chronic kidney disease, cardiovascular disease, and associated mortality.
Radvanyi Z, Yoo EJ, Kandasamy P, Salas-Bastos A, Monnerat S, Refardt J, Christ-Crain M, Hayashi H, Kondo Y, Jantsch J, Rubio-Aliaga I, Sommer L, Wagner CA, Hediger MA, Kwon HM, Loffing J, Pathare G.   +16 more
europepmc   +5 more sources

Orthopaedic diagnostic pitfalls in fibroblast growth factor 23-mediated hypophosphatemic rickets/osteomalacia in fibrous dysplasia/McCune-Albright syndrome: Two burosumab-treated cases [PDF]

Bone Reports
Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) can obscure fibroblast growth factor 23 (FGF23)-mediated hypophosphatemic rickets/osteomalacia. We report two FD/MAS patients with recurrent fractures, hypophosphatemia, elevated FGF23, and serial ...
Tomoo Nakagawa, Jungo Imanishi, Ayako Koda, Taisuke Matsuyama, Kenji Sato, Asako Yamamoto, Kentaro Matsui, Yoshinobu Watanabe, Hirotaka Kawano   +8 more
doaj   +2 more sources

Direct and indirect effects of fibroblast growth factor 23 on the heart

Frontiers in Endocrinology, 2023
Fibroblast growth factor (FGF)23 is a bone-derived phosphotropic hormone that regulates phosphate and mineral homeostasis. Recent studies have provided evidence that a high plasma concentration of FGF23 is associated with cardiac disease, including left ...
Toshiaki Nakano, Toshiaki Nakano, Hiroshi Kishimoto, Masanori Tokumoto   +3 more
doaj   +1 more source

Serum intact fibroblast growth factor 23 in healthy paediatric population

Open Medicine, 2021
It is believed that fibroblast growth factor 23 (FGF23) can become an early biomarker of chronic kidney disease progression. Data on FGF23 age dependency are inconsistent.
Stanczyk Malgorzata, Chrul Slawomir, Wyka Krystyna, Tkaczyk Marcin   +3 more
doaj   +1 more source

Indoxyl sulfate induces left ventricular hypertrophy via the AhR-FGF23-FGFR4 signaling pathway

Frontiers in Cardiovascular Medicine, 2023
BackgroundPatients with chronic kidney disease (CKD) have a high risk of left ventricular hypertrophy (LVH). Fibroblast growth factor 23 (FGF23) and indoxyl sulfate (IS) are associated with LVH in patients with CKD, but the interactions between these ...
Hiroshi Kishimoto, Toshiaki Nakano, Kumiko Torisu, Masanori Tokumoto, Yushi Uchida, Shunsuke Yamada, Masatomo Taniguchi, Takanari Kitazono   +7 more
doaj   +1 more source