Stability and degradation of fibroblast growth factor 23 (FGF23): the effect of time and temperature and assay type. [PDF]
Osteoporos Int, 2016 There is growing need for a reliable assay for measuring fibroblast growth factor 23 (FGF23), a regulator of phosphorus and vitamin D. In this work, we analyze and compare the performance of three available assays, including the effect of temperature and time.
El-Maouche D +7 more
europepmc +4 more sources
The Measurement and Interpretation of Fibroblast Growth Factor 23 (FGF23) Concentrations. [PDF]
Calcif Tissue Int, 2023 AbstractTwo decades after the discovery of the hormone FGF23, we know more about phosphate homeostasis as it turned out that FGF23 is the central hormone that regulates this. Hereditary hypophosphatemic rickets and tumor-induced osteomalacia could by then be explained, by autonomous FGF23 production, and the nephrology field was excited by this new ...
Heijboer AC, Cavalier E.
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Glucocorticoids dexamethasone and prednisolone suppress fibroblast growth factor 23 (FGF23). [PDF]
J Mol Med (Berl), 2021 Abstract Fibroblast growth factor 23 (FGF23) is a hormone mainly secreted by bone cells. Its most prominent effects are the regulation of renal phosphate reabsorption and calcitriol (active vitamin D, 1,25(OH)2D3) formation, effects dependent on its co-receptor αKlotho.
Feger M +7 more
europepmc +6 more sources
Renal Clearance of Fibroblast Growth Factor-23 (FGF23) and its Fragments in Humans. [PDF]
J Bone Miner Res, 2022 ABSTRACT Relative abundance of fibroblast growth factor-23 (FGF23) measured by the C-terminal (cFGF23, which measures both intact FGF23 and C-terminal fragments) versus intact (iFGF23, measures only intact hormone) assays varies by kidney function in humans. Differential kidney clearance may explain this finding.
Sharma S +11 more
europepmc +6 more sources
Tumor-Induced Osteomalacia With Normal Fibroblast Growth Factor-23 (FGF23) and Idiopathic Hypercalciuria. [PDF]
Cureus, 2022 Tumor-induced osteomalacia (TIO) is a rare acquired paraneoplastic syndrome characterized by low serum phosphate, phosphaturia, inappropriately low/normal levels of serum calcitriol, and normal or elevated levels of fibroblast growth factor-23 (FGF23). Finding this mesenchymal tumor is challenging since it is usually benign, small, slow-growing, and is
Velazquez-Navarro JA +3 more
europepmc +4 more sources
The Binding of Fibroblast Growth Factor 23 (FGF23) to FGF Receptor-αKlotho Complex Increases Sinoatrial Electrical Activity. [PDF]
Acta Physiol (Oxf)ABSTRACT Aim This study aims to investigate whether the Fibroblast Growth Factor 23 (FGF23) modulates the electrical activity of sinoatrial (SAN) cells. The canonical function of FGF23 is to regulate body phosphorus and calcium homeostasis by activating the FGF1 receptors (FGFR1)/α‐Klotho complex in the kidney and parathyroid glands.
Bertoli G +10 more
europepmc +2 more sources
Fibroblast growth factor 23 (FGF23) level is associated with ultrafiltration rate in patients on hemodialysis. [PDF]
Heart Vessels, 2021 AbstractFibroblast growth factor 23 (FGF23) is a bone-derived hormone that regulates renal phosphate reabsorption and vitamin D synthesis in renal proximal tubules. High circulating FGF23 levels are associated with increased mortality in patients with chronic kidney disease and those on dialysis.
Nishizawa Y +8 more
europepmc +4 more sources
Insulin suppresses the production of fibroblast growth factor 23 (FGF23). [PDF]
Proc Natl Acad Sci U S A, 2018 Significance Fibroblast growth factor 23 (FGF23) regulates phosphate and vitamin D metabolism and induces left heart hypertrophy. The importance of FGF23 is supported by the consequences of FGF23 deficiency: FGF23-deficient mice have a significantly reduced life span and recapitulate human age-associated diseases.
Bär L +7 more
europepmc +4 more sources
New Aspects of the Kidney in the Regulation of Fibroblast Growth Factor 23 (FGF23) and Mineral Homeostasis. [PDF]
Int J Mol Sci, 2020 The bone-derived hormone fibroblast growth factor 23 (FGF23) acts in concert with parathyroid hormone (PTH) and the active vitamin D metabolite calcitriol in the regulation of calcium (Ca) and phosphate (P) homeostasis. More factors are being identified to regulate FGF23 levels and the endocrine loops between the three hormones.
Mace ML, Olgaard K, Lewin E.
europepmc +5 more sources
Effects of Fibroblast Growth Factor 23 (FGF23) on the Cardiovascular System: A Review of Literature. [PDF]
CureusFibroblast growth factor 23 (FGF23) is a hormone that plays a crucial role in phosphate metabolism; its synthesis increases with phosphate intake. The effect of FGF23 is reduced by the decrease in Klotho protein in patients with chronic kidney disease (CKD).
Diaz-Haaz DI +5 more
europepmc +3 more sources