Results 111 to 120 of about 10,197,473 (297)

Supplementary Figures S1-S2 from Resistance to Chemotherapy Is Associated with Fibroblast Growth Factor Receptor 4 Up-Regulation

, 2009
Supplementary Figures S1-S2 from Resistance to Chemotherapy Is Associated with Fibroblast Growth Factor Receptor 4 Up ...
Johannes Bange (14976618), Hans-Jürgen Berger (14976615), Pjotr Knyazev (506453), Andreas Roidl (116002), Sushil Kumar (197871), Axel Ullrich (1083)   +5 more
core   +1 more source

Targeting the fibroblast growth factor receptor family in cancer [PDF]

, 2016
Fibroblast growth factors (FGFs) regulate a plethora of biological functions, in both the embryonic and adult stages of development, binding their cognate receptors and thus activating a variety of downstream signalling pathways.
Cuffe, Sinead, O’Byrne, Kenneth, Rafee, Shereen, Finn, Stephen, Gately, Kathy, Hallinan, Niamh   +5 more
core   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Supplementary Table S2 from Fibroblast growth factor receptor-mediated signals contribute to the malignant phenotype of non-small cell lung cancer cells: therapeutic implications and synergism with epidermal growth factor receptor inhibition

, 2008
Supplementary Table S2 from Fibroblast growth factor receptor-mediated signals contribute to the malignant phenotype of non-small cell lung cancer cells: therapeutic implications and synergism with epidermal growth factor receptor ...
Heidelinde Cantonati (15037721), Walter Berger (194987), Leonilla Elbling (15037718), Brigitte Marian (420584), Bettina Grasl-Kraupp (476360), Gudrun Sonvilla (15037712), Sigrid Allerstorfer (15037709), Michael Grusch (470621), Hendrik Fischer (6637304), Klaus Holzmann (14907294), Christine Gauglhofer (14907282), Ninon Taylor (452266), Ulrike Setinek (15037715), Michael Micksche (2377774)   +13 more
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Physiological concentrations of gangliosides GM1, GM2 and GM3 differentially modify basic-fibroblast-growth-factor-induced mitogenesis and the associated signalling pathway in endothelial cells

, 1999
It has been suggested that gangliosides can influence the growth of cells by modulation of growth-factor-receptor signalling. The activation of endothelial cells (EC) during angiogenesis is crucial for tumour growth and for metastasis, also for numerous ...
Shant Kumar (83955), Mark Slevin (41459), Xiaotong He (303933), John Gaffney (41466)   +3 more
core  

Supplementary Fig. S1 from Fibroblast growth factor receptor-mediated signals contribute to the malignant phenotype of non-small cell lung cancer cells: therapeutic implications and synergism with epidermal growth factor receptor inhibition

, 2008
Supplementary Fig. S1 from Fibroblast growth factor receptor-mediated signals contribute to the malignant phenotype of non-small cell lung cancer cells: therapeutic implications and synergism with epidermal growth factor receptor ...
Heidelinde Cantonati (15037721), Walter Berger (194987), Leonilla Elbling (15037718), Brigitte Marian (420584), Bettina Grasl-Kraupp (476360), Gudrun Sonvilla (15037712), Sigrid Allerstorfer (15037709), Michael Grusch (470621), Hendrik Fischer (6637304), Klaus Holzmann (14907294), Christine Gauglhofer (14907282), Ninon Taylor (452266), Ulrike Setinek (15037715), Michael Micksche (2377774)   +13 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Research progress of fibroblast growth factor receptor in gastric cancer

Zhongguo linchuang yanjiu
The incidence and mortality of gastric cancer are in the forefront of the tumor, and the prognosis is poor, especially in the middle and advanced stage. Even with comprehensive treatment, the 5- year survival is very low.
CHEN Meili, YUAN Yihang, YANG Hui, RUAN Luxi, LEI Jing, ZHANG Quan'an
doaj   +1 more source