Results 101 to 110 of about 10,197,473 (297)

Advanced Research of Fibroblast Growth Factor Receptor 
in Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2013
Lung cancer is severely threatening human health. In recent years, the treatment for lung adenocarcinoma has made a great progress, targeted therapy has been widely applied in clinic, and benefits amount of patients. However, in squamous cell lung cancer,
Dan PU, Mei HOU
doaj   +1 more source

Angiogenesis-dependent and independent phases of intimal hyperplasia. [PDF]

, 2004
BACKGROUND: Neointimal vascular smooth muscle cell (VSMC) proliferation is a primary cause of occlusive vascular disease, including atherosclerosis, restenosis after percutaneous interventions, and bypass graft stenosis. Angiogenesis is implicated in the
De Muinck, E, Ferrara, N, Simons, M, Khurana, R, Zhuang, Z, Martin, JF, Murakami, M, Zachary, I, Bhardwaj, S, Yla-Herttuala, S   +9 more
core  

Amelioration of Type 2 Diabetes by Antibody-Mediated Activation of Fibroblast Growth Factor Receptor 1

, 2011
Antibody-mediated activation of fibroblast growth factor receptor 1 reverses the diabetic phenotype in mice, likely by affecting brown adipose tissues.
Ellen Filvaroff, Bo Feng, David West, Hok Seon Kim, Yongmei Chen, Scot Marsters, Maya Leabman, Elizabeth Luis, Ai-Luen Wu, Howard Stern, Yan Wu, Daniel Yansura, Jun Li, Lance Kates, Junichiro Sonoda, Nicholas van Bruggen, Scott Stawicki, Anne Wong, Jose Zavala-Solorio, Ganesh Kolumam, Andrew S. Peterson, Khanhky Phamluong, Li Li   +22 more
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Fibroblast growth factor signaling in macrophage polarization: impact on health and diseases

Frontiers in Immunology
Fibroblast growth factors (FGFs) are a versatile family of peptide growth factors that are involved in various biological functions, including cell growth and differentiation, embryonic development, angiogenesis, and metabolism. Abnormal FGF/FGF receptor
Luyao Shen, Yongsheng Li, Yongsheng Li, Huakan Zhao   +3 more
doaj   +1 more source

Supplementary Data from Antiangiogenic Activity of a Neutralizing Human Single-Chain Antibody Fragment against Fibroblast Growth Factor Receptor 1

, 2010
Supplementary Data from Antiangiogenic Activity of a Neutralizing Human Single-Chain Antibody Fragment against Fibroblast Growth Factor Receptor
Marco Presta (164845), Patrizia Alessi (15036417), Roberto Ronca (1621849), Daria Leali (2048407), Chiara Urbinati (15040619), Patrizia Benzoni (15040616), Daniela Coltrini (15036420), Michela Corsini (6955433), Stefano Calza (23543), Mirella Belleri (9960233), Patrizia Dell'Era (15040622)   +10 more
core   +1 more source

Inhibition von FGFR, PDGFR und VEGFR hemmt Tumorwachstum, Angiogenese und Metastasierung des Pankreaskarzinoms in einem experimentellen Modell [PDF]

, 2013
Die Expression und Aktivierung von Rezeptor-Tyrosinkinasen (RTK) für fibroblast growth factor (FGF), platelet-derived growth factor (PDGF) und vascular endothelial growth factor (VEGF) konnten mit gesteigertem Tumorwachstum, Metastasierung und ...
Taeger, Johannes Kai
core   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

A coacervate-based platform for growth factor delivery [PDF]

, 2013
Growth factors participating in a variety of biological processes have great potential in regenerative medicine. However, unprotected growth factors degrade quickly and have little efficacy at tissue repair.
Chu, Hunghao
core  

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source