Results 81 to 90 of about 365,165 (302)

Fibroblast Growth Factor-10 (FGF-10) Mobilizes Lung-resident Mesenchymal Stem Cells and Protects Against Acute Lung Injury. [PDF]

, 2016
FGF-10 can prevent or reduce lung specific inflammation due to traumatic or infectious lung injury. However, the exact mechanisms are poorly characterized.
Bai, Chunxue, Liu, Jie, Pan, Jue, Qu, Jieming, Rong, Linyi, Seeley, Eric J, Song, Yuanlin, Tang, Xinjun, Tong, Lin, Wang, Qin, Zhou, Jian, Zhu, Xiaodan   +11 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

The heparan sulfate co-receptor and the concentration of fibroblast growth factor-2 independently elicit different signalling patterns from the fibroblast growth factor receptor

Cell Communication and Signaling, 2010
Background The fibroblast growth factor receptor (FGFR) interprets concentration gradients of FGF ligands and structural changes in the heparan sulfate (HS) co-receptor to generate different cellular responses.
Duchesne Laurence, Zhu Hongyan, Rudland Philip S, Fernig David G   +3 more
doaj   +1 more source

Elucidating glycosaminoglycan–protein–protein interactions using carbohydrate microarray and computational approaches [PDF]

, 2011
Glycosaminoglycan polysaccharides play critical roles in many cellular processes, ranging from viral invasion and angiogenesis to spinal cord injury.
Bothwell, C. J. Rogers, Chao, Clement, de Paz, Dechant, Faham, Gama, Huang, K. C. Garcia, Keiser, Khunrae, Kim, L. C. Hsieh-Wilson, Lowes, Mukai, Mulloy, Oohira, P. M. Clark, Pellegrini, Petitou, R. Abrol, Raman, Rapp, Rawat, Raza, Roux, S. E. Tully, Schlessinger, Shelton, Shipp, Spivak-Kroizman, Strom, Sugahara, Sweeney, Tully, Tully, Vaudry, W. A. Goddard, Zhang   +39 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A peptide derived from TIMP-3 inhibits multiple angiogenic growth factor receptors and tumour growth and inflammatory arthritis in mice [PDF]

, 2013
The binding of vascular endothelial growth factor (VEGF) to VEGF receptor-2 (VEGFR-2) on the surface of vascular endothelial cells stimulates many steps in the angiogenic pathway.
A Janssen, A Kim, A Tuuttila, Ahmed H. Mujamammi, B AnandApte, C Alam, C Fischer, CA Bootle-Wilbraham, CA Staton, Claire E. Lewis, D Matei, DR Robinson, DW Seo, F Kazazi-Hyseni, FX Gomis-Ruth, G Bergers, G Fassina, G Fuh, H Gitay-Goren, HB Patel, J Mintseris, J Waltenberger, JC Tille, JE Rundhaug, JH Qi, JH Qi, JR Jackson, JR Worley, K Maskos, KP Langton, KP Langton, LA Kelley, M Bandt De, M Benedetto Di, M Lohela, M Wisniewska, Michael D. Barker, Michael P. Seed, MS Brozzo, Munitta Muthana, N Manabe, Nicola J. Brown, Q Ebrahem, Rita Jones, S Rosengren, S Sivaprasad, SE Hoegy, V Chabottaux, WH Yu, WU Kim, Y Cao, Y Matsumoto, Yung-Yi Chen   +52 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

The structure and function of vertebrate fibroblast growth factor receptor 1 [PDF]

, 2002
The vertebrate fibroblast growth factor receptor 1 (FGFR1) is alternatively spliced generating multiple splice variants that are differentially expressed during embryo development and in the adult body.
Groth, C., Lardelli, M.
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Phosphorus Restriction Changes the Expression of Fibroblast Growth Factor 23 and Its Receptors in Laying Hens

Frontiers in Physiology, 2020
Dietary phosphorus oversupply wastes non-renewable natural resources and raises environmental concerns in animal agriculture. We hypothesized that laying hens do not need large safety margins for dietary phosphorus because of the existence of fibroblast ...
Zhouzheng Ren, Jiakun Yan, Qianli Hu, Xinshuai Liu, Chong Pan, Yanli Liu, Xiaozhen Zhang, Xin Yang, Xiaojun Yang   +8 more
doaj   +1 more source