Results 61 to 70 of about 367,714 (351)
Journal of Medical Case Reports, 2023 Introduction Advances in the treatment of biliary tract cancer have been made possible through gains in genomic and epigenetic tumor understanding. The use of fibroblast growth factor receptor inhibitor has enabled significant clinical improvement in a ...
Andreas Edwin Juarso +2 more
doaj +1 more source
Tyrosine kinase A, C and fibroblast growth factor-2 receptors in bovine embryos cultured in vitro [PDF]
, 2013 Neurotrophins and basic fibroblast growth factor are ligands of tyrosine kinase receptors, though they bind to different tyrosine kinase receptor classes.
Caamaño, J.N. (José) +8 more
core
Molecular characteristics of fibroblast growth factor–fibroblast growth factor receptor–heparin-like glycosaminoglycan complex [PDF]
Proceedings of the National Academy of Sciences, 1999 Fibroblast growth factor (FGF) family plays key roles in development, wound healing, and angiogenesis. Understanding of the molecular nature of interactions of FGFs with their receptors (FGFRs) has been seriously limited by the absence of structural information on FGFR or FGF–FGFR complex.
G, Venkataraman +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Receptor Tyrosine Kinases Fall into Distinct Classes Based on Their Inferred Signaling Networks [PDF]
, 2013 Although many anticancer drugs that target receptor tyrosine kinases (RTKs) provide clinical benefit, their long-term use is limited by resistance that is often attributed to increased abundance or activation of another RTK that compensates for the ...
Grenier, Jennifer K. +6 more
core +1 more source
FGFR4 (fibroblast growth factor receptor 4) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Peer ...
Peláez-García, A +2 more
openaire +3 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Fibroblast Growth Factor Receptor, a Novel Receptor for Vegetative Insecticidal Protein Vip3Aa
Toxins, 2018 Vegetative insecticidal proteins (Vips), which are secreted by some Bacillus thuringiensis strains during vegetative growth, exhibit high virulence to many pests.
Kun Jiang +5 more
doaj +1 more source
Biomedicines, 2021 Recently, non-alcoholic fatty liver disease (NAFLD) has emerged as a predominant health concern affecting approximately a quarter of the world’s population.
Sayali Bhave, Han Kiat Ho
doaj +1 more source
The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis. [PDF]
, 2017 We recently found that integrin αvβ3 binds to fibroblast growth factor (FGF)-αvβ31 (FGF1), and that the integrin-binding defective FGF1 mutant (Arg-50 to glutamic acid, R50E) is defective in signalling and antagonistic to FGF1 signalling. R50E suppressed
Hamada, Yoshinosuke +10 more
core +2 more sources