Molecular interaction between natural IgG and ficolin - Mechanistic insights on adaptive-innate immune crosstalk [PDF]
, 2014 10.1038/srep03675Scientific ...
Anand, Ganesh Srinivasan +4 more
core +1 more source
PLoS ONE, 2012 BackgroundThe innate immune system encompasses various recognition molecules able to sense both exogenous and endogenous danger signals arising from pathogens or damaged host cells.
Christian Gytz Ammitzbøll +7 more
doaj +1 more source
Ficolin-2 levels and FCN2 haplotypes influence hepatitis B infection outcome in Vietnamese patients. [PDF]
PLoS ONE, 2011 Human Ficolin-2 (L-ficolins) encoded by FCN2 gene is a soluble serum protein that plays an important role in innate immunity and is mainly expressed in the liver.
Tong V Hoang +7 more
doaj +1 more source
Expression of human ficolin-2 in hepatocytes confers resistance to infection by diverse hepatotropic viruses [PDF]
, 2019 The liver-expressed pattern recognition receptors (PRRs) mannose binding lectin (MBL), ficolin-2 and ficolin-3 contribute to the innate immune response by activating complement.
Ball, Jonathan K. +11 more
core +2 more sources
M-ficolin in children with cancer
Immunobiology, 2011 M-ficolin (ficolin-1) is a complement-activating pattern-recognition molecule structurally related to mannan-binding lectin. It is produced by monocytes and neutrophils, and is found in serum. Its biological role is largely unknown. We assessed M-ficolin concentration in serum from pediatric cancer patients.
Schlapbach, Luregn J. +6 more
openaire +4 more sources
Mannan‐Binding Lectin, L‐Ficolin and H‐Ficolin Selectively Binds to Different Bacteria [PDF]
Scandinavian Journal of Immunology, 2004 Mannan‐binding lectin (MBL), L‐ficolin and H‐ficolin are pattern recognition molecules of the innate immune system. We investigated the ability of these molecules to bind to different serotypes and noncapsulated variants of Streptococcus pneumonia and Staphylococcus aureus. We found that MBL binds to noncapsulated S. aureus strain (Wood) but not any of
Jens Chr. Jensenius +4 more
openaire +2 more sources
Emerging role of ficolins in autoimmune diseases
Pharmacological Research, 2021 Ficolins are pattern-recognition molecules (PRMs) that could form complexes with mannose-binding lectin-associated serine proteases (MASPs) to trigger complement activation via the lectin pathway, thereby mediating a series of immune responses including opsonization, phagocytosis and cytokine production.
Peng Wang, Qian Wu, Zong-Wen Shuai
openaire +2 more sources
Low levels of mannan-binding lectin or ficolins are not associated with an increased risk of cytomegalovirus disease in HIV-infected patients. [PDF]
PLoS ONE, 2013 BACKGROUND: In HIV-infected patients, prediction of Cytomegalovirus (CMV) disease remains difficult. A protective role of mannan-binding lectin (MBL) and ficolins against CMV disease has been reported after transplantation, but the impact in HIV-infected
Adrian Egli +12 more
doaj +1 more source
Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation [PDF]
, 2015 MFAP4 (microfibrillar-associated protein 4) is an extracellular glycoprotein found in elastic fibers without a clearly defined role in elastic fiber assembly.
Heumüller, Stefanie E +11 more
core +1 more source
Iranian Biomedical Journal, 2021 Background Premature ovarian failure is a heterogeneous disorder, leading to early menopause. Several genes have been identified as the cause of non-syndromic POF. Our aim was to explore the genetic defects in Iranian patients with POF.
Soophia Mehrjooy +4 more
semanticscholar +1 more source