Results 91 to 100 of about 2,459 (190)

TCDD and FICZ administration inhibit EAE establishment and dampen T cell expansion and infiltration of the central nervous system.

, 2013
A) Clinical scores of mice immunized with MOG/CFA which received either vehicle (filled circles), TCDD (inverted triangles) or FICZ (filled squares) i.p.
Helena Ahlfors (433264), Keiji Hirota (484908), Brigitta Stockinger (277480), Paola Di Meglio (229474), João H. Duarte (484907)   +4 more
core   +1 more source

Astrocytes Respond to Environment-Relevant Doses TCDD in a Specific Manner Which Is Different from the Endogenous AhR Ligand (FICZ)

Environment & Health
Astrocytes play an important role in the nervous system's response to external stimulation. Environmental pollutants could activate astrocytes into A1 (toxic) or A2 (protective) types and induce different effects. Meanwhile, the aryl hydrocarbon receptor (AhR) is an environmental molecule sensor in the body and has various ligands.
Rui Sha, Yangsheng Chen, Tong Xu, Guanglei Yang, Li Xu, Heidi Qunhui Xie, Bin Zhao   +6 more
openaire   +2 more sources

Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors

Nature Communications, 2017
“Although aberrant promoter DNA hypermethylation is a hallmark of cancer, it is not clear whether it is sufficient to drive transformation. Here, the authors use CRISPR-dCas9 to perform hit-and-run epigenetic editing, which prevents senescence entry in ...
Emily A. Saunderson, Peter Stepper, Jennifer J. Gomm, Lily Hoa, Adrienne Morgan, Michael D. Allen, J. Louise Jones, John G. Gribben, Tomasz P. Jurkowski, Gabriella Ficz   +9 more
doaj   +1 more source

Correlation analysis of the FICZ + RA-elicited signalsome.

, 2015
(A) The dendrogram resultant from the hierarchical clustering analysis of the data presented in Fig 5 using the Pearson correlation coefficient as the distance metric and the average linkage method.
Robert J. MacDonald (784968), Rodica P. Bunaciu (390456), Dorian H. LaTocha (784969), Andrew Yen (390458), Holly A. Jensen (390454), Jeffrey D. Varner (197251)   +5 more
core   +1 more source

FICZ induces a c-Cbl-AhR association (mean fluorescence).

, 2015
HL-60 cells were initiated in culture at 0.1 x 106 cells/ml with 1 μM RA, 100 nM FICZ, 1 μM α-NF and 1 μM β-NF as indicated. Cells were harvested, fixed for 10 min with 2% paraformaldehyde, and permeabilized with ice cold methanol.
Robert J. MacDonald (784968), Rodica P. Bunaciu (390456), Dorian H. LaTocha (784969), Andrew Yen (390458), Holly A. Jensen (390454), Jeffrey D. Varner (197251)   +5 more
core   +1 more source

8β-hydroxy-9(11),13-abietadien-12-one and margolone ameliorate intestinal epithelial barrier dysfunction via aryl hydrocarbon receptor activation in a Caco-2 monolayer model

Phytomedicine Plus
Background: Disrupting the intestinal epithelial barrier function causes several diseases, including inflammatory bowel disease (IBD). Indole metabolite 6-formylindolo[3,2-b]carbazole (FICZ) has been reported to ameliorate this disruption by activating ...
Katsutoshi Nishino
doaj   +1 more source

Quercetin, Resveratrol, and Curcumin Are Indirect Activators of the Aryl Hydrocarbon Receptor (AHR)

, 2012
Several polyphenols have been shown to activate the aryl hydrocarbon receptor (AHR) in spite of the fact that they bind to the receptor with low affinity.
Bengtsson, J, Rannug, U, Wincent, Emma,, Emma Wincent, Rannug, Ulf,, Mohammadi-Bardbori, A, Wincent, E, Agneta Rannug, Rannug, A,, Ulf Rannug, Bengtsson, Johanna,, Mohammadi-Bardbori, Afshin, Rannug, Agneta, Johanna Bengtsson, Afshin Mohammadi-Bardbori   +14 more
core   +1 more source

FICZ modulates RA-elicited signalsome.

, 2015
HL-60 cells were initiated in culture at 0.1 x 106 cells/ml with 1 μM RA, 100 nM FICZ, 1 μM α-NF and 1 μM β-NF as indicated. Western blot assay of whole cell lysates is shown for AhR, c-Cbl, Cbl-b, CD38, Lyn, Fgr, pY416SFK, c-Raf, pS621c-Raf, pS289/296 ...
Robert J. MacDonald (784968), Rodica P. Bunaciu (390456), Dorian H. LaTocha (784969), Andrew Yen (390458), Holly A. Jensen (390454), Jeffrey D. Varner (197251)   +5 more
core   +1 more source

Porphyromonas Gingivalis Exacerbates Atherosclerosis By Inhibiting The Ahr/Ido Pathway

International Dental Journal
Aim or purpose: To investigate the role of the AhR/IDO (Aryl Hydrocarbon Receptor/Indoleamine 2,3-Dioxygenase) pathway, a key regulator of kynurenine (Kyn) metabolism, in modulating AS progression facilitated by periodontitis with Porphyromonas ...
Xinyue Wang, Wenlei Wu, Ting Hao, Tong Zhao, Zi Xuan Fan, Yu Liu, Jie Yang   +6 more
doaj   +1 more source

The aryl hydrocarbon receptor: differential contribution to T helper 17 and T cytotoxic 17 cell development.

PLoS ONE, 2014
The aryl hydrocarbon receptor (AhR) has been shown to be required for optimal Thelper (Th) 17 cell activation. Th17 cells provide immunity against extracellular pathogens and are implicated in autoimmune diseases.
Mark D Hayes, Vitalijs Ovcinnikovs, Andrew G Smith, Ian Kimber, Rebecca J Dearman   +4 more
doaj   +1 more source