Results 71 to 80 of about 2,459 (190)

Oxidative stress induced by UVA photoactivation of the tryptophan UVB photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) inhibits nucleotide excision repair in human cells

, 2020
Potentially mutagenic DNA lesions induced by UVB (wavelengths 280-320 nm) are important risk factors for solar ultraviolet (UV) radiation-induced skin cancer.
Reto Brem (8017), Peter Macpherson (10902), Melisa Guven (3192867), Peter Karran (10906)   +3 more
core  

Aryl hydrocarbon receptor regulates IL-22 receptor expression on thymic epithelial cell and accelerates thymus regeneration

npj Regenerative Medicine, 2023
Improving regeneration of damaged thymus is important for reconstituting T-cell immunity. Interleukin-22 (IL-22) was proved to improve thymus regeneration through recovering thymic epithelial cells (TECs).
Jingyi Shen, Ying Wang, Fei Zheng, Shuo Cao, Qiu Lan, Kailin Xu, Bin Pan   +6 more
doaj   +1 more source

Advances in the Gut‐Lung Axis and Bronchial Asthma: From Mechanisms to Therapeutic Potential

Clinical and Translational Allergy, Volume 15, Issue 12, December 2025.
ABSTRACT Background Bronchial asthma (hereafter referred to as asthma) is a heterogeneous disease characterized by chronic airway inflammation, airway hyperresponsiveness (AHR), and reversible airflow limitation. Recent advancements in the “gut‐lung” axis concept have elucidated the intricate immunometabolic crosstalk between the gastrointestinal tract
Ting Zheng, Yi Huang, Hongmei Yao
wiley   +1 more source

THE TRANSACTIVATION ACTIVITY OF COMMON POLYPHENOLS ON BOTH RAT AND HUMAN ARYL HYDROCARBON RECEPTORS (AHR) IN THE PRESENCE AND ABSENCE OF AHR ENDOGENOUS (FICZ) AND XENOBIOTIC (TCDD) LIGANDS [PDF]

, 2019
Introduction. Aryl hydrocarbon receptor (AhR) is known as a mediator of the response to xenobiotic. Recently, however FICZ (6-formylindolo[3,2-b] carbazole), a tryptophan (Trp) derivative, emerged as an endogenous ligand displaying the highest affinity ...
Scippo, Marie-Louise, Muller, Marc, Connolly, L, Doan, Thi-Que   +3 more
core   +1 more source

Postbiotic from Lactobacillus acidophilus Inhibits Ferroptosis in Intestinal Stem Cells via Microbiota–AhR Axis to Mitigate Colitis

Food Frontiers, Volume 6, Issue 6, Page 2975-2993, November 2025.
Lacidophilin tablets alleviate colitis by regulating gut microbiota balance and maintaining intestinal barrier integrity. ABSTRACT Inflammatory bowel disease (IBD) is a chronic, progressive intestinal disorder. Dysbiosis of the gut microbiota is strongly implicated in the onset and progression of IBD.
Denglong Sun, Chenxuan Wang, Qigui Fan, Yang Zhan, Xiaoying Cheng, Jingwen Zhang, Qinxin Wang, Yingmeng Li, Qiong Li, Yanxia Xiong, Wenjun Liu   +10 more
wiley   +1 more source

FICZ activating AHR protects against intestinal injury in mice with DSS-induced colitis by regulating intestinal flora and metabolism

, 2023
Abstract Background: Aromatic hydrocarbon receptors (AHR) are widely expressed in the intestinal barrier and play a regulatory role in intestinal inflammation and immunity. Objectives: In this study, a dextran sulfate (DSS)-induced colitis mouse model was established to detect the effects of AHR activation on the intestinal barrier, flora, and ...
Liping Yin, Linxin Jiang, Ziyang Zhou, Jinying Zhao, Jianguo Tang, Zetian Wang   +5 more
openaire   +1 more source

Aryl Hydrocarbon Receptor in Health and Disease

MedComm, Volume 6, Issue 11, November 2025.
Based on the structure and ligands of AhR, this review introduces the AhR‐related signaling pathways and their roles in health and diseases. Agonists and antagonists of AhR as well as new strategies for treatment using the microbial–AhR axis are summarized. A prospect was made for the future use of AhR as a therapeutic target.
Haonan Li, Yufeng Fan, Jizheng Liu, Shumin Dong, Bin Wen, Yunfei Zhang, Xiaocui Wang, Xuemei Duan, Ying Hu, Ze Yan, Huifeng Shang, Yukai Jing   +11 more
wiley   +1 more source

AhR Activation Ameliorates Intestinal Barrier Damage in Immunostressed Piglets by Regulating Intestinal Flora and Its Metabolism

Animals
The primary factor leading to elevated rates of diarrhea and decreased performance in piglets is immunological stress. The regulation of immune stress through the intestinal flora is a crucial mechanism to consider.
Xiaomei Wu, Yalei Zhang, Mengyao Ji, Wen Yang, Tanjie Deng, Guanyu Hou, Liguang Shi, Wenjuan Xun   +7 more
doaj   +1 more source

Transition to naïve human pluripotency mirrors pan-cancer DNA hypermethylation

Nature Communications, 2020
Epigenetic reprogramming is a hallmark of cancer. Here the authors find that resetting primed human embryonic stem cells to naïve state results in the acquisition of a DNA methylation landscape that mirrors the cancer DNA methylome and provides evidence ...
Hemalvi Patani, Michael D. Rushton, Jonathan Higham, Saul A. Teijeiro, David Oxley, Pedro Cutillas, Duncan Sproul, Gabriella Ficz   +7 more
doaj   +1 more source

The Effect of Endogenous Ligands of the Aryl Hydrocarbon Receptor on Antibody Expression in a Human B-Cell Model [PDF]

, 2021
Small changes in antibody expression have broad impacts on human health and disease. An environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces profound immune suppression in animal models in an aryl hydrocarbon receptor (AhR)-mediated ...
Benedict, Valerie
core   +1 more source