Results 51 to 60 of about 2,459 (190)

Tryptophan Photoproduct FICZ Upregulates IL1A, IL1B, and IL6 Expression via Oxidative Stress in Keratinocytes

Oxidative Medicine and Cellular Longevity, 2018
Ultraviolet B (UVB) irradiation activates the aryl hydrocarbon receptor (AHR), generates the reactive oxygen species (ROS), and induces the production of proinflammatory cytokines such as IL1A, IL1B, and IL6. 6‐Formylindolo[3,2‐b]carbazole (FICZ) is a tryptophan‐derived photoproduct that is induced by UVB irradiation and activates the AHR. However, its
Yuka Tanaka, Hiroshi Uchi, Akiko Hashimoto-Hachiya, Masutaka Furue   +3 more
openaire   +2 more sources

Exploring the impact of endogenous AHR ligand, 6-formylindole [3,2-b]carbazole (FICZ) on the microbiota-gut-brain axis in chronic stress-induced depression in rats [PDF]

Trends in Pharmaceutical Sciences
Aryl hydrocarbon receptor (AHR) is a nuclear receptor that mediates responses to environmental stimuli. The microbiome, influenced by factors such as nutrition, antibiotics, stress, and infection, plays a crucial role in mood, cognition, and mental ...
Najmeh Ekhtiyardar, Fereshteh Asadi Dolatabad, Amin Reza Akbarizadeh, Sanaz Salek, Neda Hajizadeh, Mohammad Javad Khoushnoud, Afshin Mohammadi-Bardbori   +6 more
doaj   +1 more source

A new insight into the role of aryl hydrocarbon receptor (AhR) in the migration of glioblastoma by AhR-IL24 axis regulation

Environment International, 2021
Cancer occurrence and development are closely related to the environment. Aryl hydrocarbon receptor (AhR) is an important receptor mediating the toxic effects of many environmental compounds, and is also involved in regulating tumor cell migration ...
Yiyun Liu, Yangsheng Chen, Rui Sha, Yunping Li, Tong Xu, Xiaoxu Hu, Li Xu, Qunhui Xie, Bin Zhao   +8 more
doaj   +1 more source

Microbiome‐Derived Tryptophan Metabolites Regulate AhR Signaling to Restore Epithelial Barrier Integrity in Inflammatory Bowel Disease

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
The graphical abstract illustrates how microbiome‐derived indoles activate the aryl hydrocarbon receptor to restore the intestinal barrier. The picture contrasts the “leaky gut” state with the restored homeostasis achieved through AMPK, Nrf2, and IL‐22 signaling.
Mohammad Ali Mahdiabadi, Asma Moghaddam, Nafiseh Erfanian   +2 more
wiley   +1 more source

Building an Interleukin‐10‐Producing Identity: How B Cells Acquire Interleukin‐10 Competence and How Plasma Cell Differentiation Consolidates This Program

Immunological Reviews, Volume 343, Issue 1, October 2026.
ABSTRACT Interleukin (IL)‐10‐producing B cells represent an archetype for the regulatory functions of B cells. Here, we review the cell‐surface receptors and transcriptional regulators that control IL‐10 expression in B cells and enable their regulatory function in vivo.
Bui Thi Cuc, Yanli Tong, Zhiguo Wu, Daniel Alvarez‐Simon, Simon Fillatreau   +4 more
wiley   +1 more source

Tryptophan metabolism in colorectal cancer: From mechanistic insights to novel therapeutic strategies

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Tryptophan metabolism modulates CRC via three microbiota‐regulated pathways with distinct dual‐mode effects. The kynurenine pathway provides biomarkers, serotonin pathway supports SSRI‐combined immunotherapy, indole pathway yields immunostimulatory metabolites, collectively offering translational prospects.
Ran Wang, Wenke Shen, Ping Yang, Dongxue Yang, Yuepeng Cao, Yuping Zhou   +5 more
wiley   +1 more source

Butyrate acts through HDAC inhibition to enhance aryl hydrocarbon receptor activation by gut microbiota-derived ligands

Gut Microbes, 2022
Aryl hydrocarbon receptor (AhR) is a critical player in the crosstalk between the gut microbiota and its host. However, factors regulating AhR within the gut, which is a complex metabolomic environment, are poorly understood.
Morgane Modoux, Nathalie Rolhion, Jeremie H. Lefevre, Cyriane Oeuvray, Petr Nádvorník, Peter Illes, Patrick Emond, Yann Parc, Sridhar Mani, Zdenek Dvorak, Harry Sokol   +10 more
doaj   +1 more source

Research Progress on the Regulatory Mechanisms of Gut Microbiota in Methamphetamine Addiction and Targeted Interventions

Addiction Biology, Volume 31, Issue 9, September 2026.
METH induces gut dysbiosis with increased proinflammatory and decreased beneficial bacteria, impairs mucosal barrier with reduced SCFAs/Occludin and increased permeability, leading to endotoxin leakage. This activates HPA axis, vagus‐CNS pathways, oxidative stress, and gut‐testis axis disturbance, all synergistically causing neurotoxicity, addiction ...
Jihao Yang, Yishuang Dai, Jia Li
wiley   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, Volume 13, Issue 39, 13 July 2026.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Plasma Aryl Hydrocarbon Receptor Agonist Activity Is Associated With Inflammation and Metabolic Dysregulation in Obesity: A Cross‐Sectional Study

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 5, July 2026.
ABSTRACT Background The aryl hydrocarbon receptor (AhR) is linked to inflammation, but its plasma agonist activity and association with metabolic and inflammatory markers in obesity remain unclear. This cross‐sectional study aimed to determine the level of plasma AhR agonistic activity and its association with systemic inflammation and metabolic ...
Fatemah Bahman, Shihab Kochumon, Ashraf Al Madhoun, Areej Al‐Roub, Abdullah Bennakhi, Monira Arouj, Fahd Al‐Mulla, Rasheed Ahmad   +7 more
wiley   +1 more source