Results 61 to 70 of about 2,459 (190)

Evaluation of the clonogenic potential of day-4 FICZ-cultured CML CD34+ cells.

, 2018
A significant reduction of leukemic clonogenic potential was observed with a synergistic profile of FICZ with Imatinib (p = 0.0309, Panel A) and Dasatinib (p = 0.0292. (Panel B).
Patricia Hugues (5616785), Gladys Telliam (5616788), Jerome Artus (5616800), Ali G. Turhan (155505), Annelise Bennaceur-Griscelli (155516), Lucas E. B. Souza (5616794), Hyacinthe Johnson-Ansah (5616806), Adlen Foudi (5616809), Seda Baykal (5616797), Christophe Desterke (760909), Ivan Sloma (5616791), Melanie Gentil (5616782), Frank Griscelli (171241), Agnes Guerci (5616803)   +13 more
core   +1 more source

Tryptophan Metabolism and Aryl‐Hydrocarbon Receptor Agonists in the Gut Microbiome of People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
The gut microbiome of people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is investigated to identify changes in microbial tryptophan metabolism. We reveal a subcommunity of microbes that correlates with tryptophan metabolism that differs in structure and diversity and identify differences in stool indoles including aryl‐hydrocarbon
David J. Esteban, Brynn Conrad, Autumn Cullinan, Sharon Luong, Jason Albaum, Victoria Wilk   +5 more
wiley   +1 more source

Tapinarof as a Therapeutic Aryl Hydrocarbon Receptor‐Modulating Agent in the Treatment of Atopic Dermatitis

The Journal of Dermatology, Volume 53, Issue 6, Page 867-879, June 2026.
ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory dermatitis underpinned by Type 2 inflammation driven by cytokines such as IL‐4 and IL‐13. It is characterized by skin barrier dysfunction, Th2 immune deviation, and pruritus. While biologics and oral Janus kinase (JAK) inhibitors demonstrate high therapeutic efficacy by targeting cytokines that ...
Gaku Tsuji, Yoko Fuyuno, Koji Kawamura, Ayako Yumine, Masaki Takemura, Yasutaka Mitamura, Kazuhiko Yamamura, Takeshi Nakahara   +7 more
wiley   +1 more source

Supplementary Figure 2 from Induction of PARP7 Creates a Vulnerability for Growth Inhibition by RBN2397 in Prostate Cancer Cells

, 2023
BBQ and FICZ treatment activates AHR signaling in prostate cancer ...
Song Yi Bae (15137314), Nicki Abianeh (15137320), Krzysztof Wierbiłowicz (15305679), Chunsong Yang (15137305), Bryce M. Paschal (15305688), Aakrosh Ratan (15079353), Justin M. Drake (15082222), Tarek Abbas (15137326), David Wotton (15137329), Sachi B. Tengse (15305685), Natalia M. Dworak (15305682)   +10 more
core   +2 more sources

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, Volume 183, Issue 10, Page 2177-2196, May 2026.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

Protective Effects of Aryl Hydrocarbon Receptor Signaling in Celiac Disease Mucosa and in Poly I:C-Induced Small Intestinal Atrophy Mouse Model

Frontiers in Immunology, 2019
Aryl hydrocarbon receptor (AhR), a transcription factor activated by a large number of natural and synthetic agents, modulates the activity of immune cells in the gut and represents an important link between the environment and immune-mediated ...
Vincenzo Dinallo, Irene Marafini, Davide Di Fusco, Antonio Di Grazia, Federica Laudisi, Rami Dwairi, Omero A. Paoluzi, Giovanni Monteleone, Ivan Monteleone   +8 more
doaj   +1 more source

Aryl hydrocarbon receptor activation ameliorates experimental colitis by modulating the tolerogenic dendritic and regulatory T cell formation

Cell & Bioscience, 2022
Background Intestinal immune dysfunction is involved in the onset of Crohn’s disease (CD). Dendritic cells (DCs), antigen-presenting cells, play a key role in the maintenance of intestinal immune homeostasis.
Xiufang Cui, Ziping Ye, Di Wang, Yan Yang, ChunHua Jiao, Jingjing Ma, Nana Tang, Hongjie Zhang   +7 more
doaj   +1 more source

Analysis of Protein and Lipid Dynamics Using Confocal Fluorescence Recovery After Photobleaching

Current Protocols, Volume 6, Issue 1, January 2026.
Abstract Fluorescence recovery after photobleaching (FRAP) is a powerful, versatile, and widely accessible tool to monitor molecular dynamics in living cells that can be performed using modern confocal microscopes. Although the basic principles of FRAP are simple, quantitative FRAP analysis requires careful experimental design, data collection, and ...
Charles A. Day, Lewis J. Kraft, Minchul Kang, Anne K. Kenworthy   +3 more
wiley   +1 more source

FICZ and RA co-treatment inhibits cell proliferation and augments RA-induced G₀/G₁ cell cycle arrest.

, 2015
HL-60 cells were initiated in culture at 0.1 x 106 cells/ml with 1 μM RA, 100 nM FICZ, 1 μM α-NF and 1 μM β-NF as indicated. (A). Cells/ml as a function of time in culture. Cell densities in all the cultures remained similar for the first 48 h (averaging
Robert J. MacDonald (784968), Rodica P. Bunaciu (390456), Dorian H. LaTocha (784969), Andrew Yen (390458), Holly A. Jensen (390454), Jeffrey D. Varner (197251)   +5 more
core   +1 more source

Robinia pseudoacacia L. Flower Exosome‐Like Nanoparticles (RFELNs) Activate AhR/IL‐22 to Relieve Intestinal Barrier Dysfunction Through Regulating Gut Microbiota‐Interrelated Tryptophan Metabolism in Ulcerative Colitis Mice

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Background Intestinal barrier dysfunction is a key driver of ulcerative colitis (UC) recurrence and chronic persistence. Modulating group 3 innate lymphoid cells (ILC3) activity and tryptophan‐derived metabolites is crucial for enhancing mucosal repair in UC. Robinia pseudoacacia L. flower exosome‐like nanoparticles (RFELNs) could ameliorate intestinal
Feihan Shen, Kewen Sun, Jianguo Song, Xueping Chen, Juan Dai, Ying Qi, Liwen Zhang, Liang Ma, Elena Niccolai   +8 more
wiley   +1 more source