Results 41 to 50 of about 2,459 (190)

An endogenous tryptophan photo-product, FICZ, is potentially involved in photo-aging by reducing TGF-β-regulated collagen homeostasis [PDF]

Journal of Dermatological Science, 2018
Persistent ultraviolet (UV) radiation in the form of sunlight causes photo-aging of the skin by reducing the production of type I collagen, the major constituent of the extracellular matrix of the dermis. Transforming growth factor (TGF)-β transforms dermal fibroblasts into α2-smooth muscle actin (ACTA2)-expressing myofibroblasts.
Mika, Murai, Gaku, Tsuji, Akiko, Hashimoto-Hachiya, Yoshihito, Kawakami, Masutaka, Furue, Chikage, Mitoma   +5 more
openaire   +2 more sources

Decreased Expression of the Aryl Hydrocarbon Receptor in Ocular Behcet’s Disease

Mediators of Inflammation, 2014
Recent studies show that the aryl hydrocarbon receptor (AhR) is involved in immune responses. AhR is activated following interaction with its ligands, such as 6-formylindolo[3,2-b]carbazole (FICZ) and 2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid
Chaokui Wang, Zi Ye, Aize Kijlstra, Yan Zhou, Peizeng Yang   +4 more
doaj   +1 more source

FICZ upregulates Cyp1A1 expression.

, 2015
HL-60 cells were initiated in culture at 0.1 x 106 cells/ml with 1 μM RA, 100 nM FICZ, 1 μM α-NF as indicated for 2 h and 48 h. At 2 h post treatment, FICZ upregulates Cyp1A1 expression in HL-60 cells, reaching significance for RA+FICZ vs C (p = 0.0029 ...
Robert J. MacDonald (784968), Rodica P. Bunaciu (390456), Dorian H. LaTocha (784969), Andrew Yen (390458), Holly A. Jensen (390454), Jeffrey D. Varner (197251)   +5 more
core   +1 more source

In vitro Treatment of Mouse and Human Cells with Endogenous Ligands for Activation of the Aryl Hydrocarbon Receptor

Bio-Protocol, 2017
Activation of the aryl hydrocarbon receptor (AHR) by endogenous ligands has been implicated in a variety of physiological processes such as cell cycle regulation, cell differentiation and immune responses. It is reported that tryptophan metabolites, such
Taisho Yamada, Akinori Takaoka
doaj   +1 more source

Impairment of aryl hydrocarbon receptor signalling promotes hepatic disorders in cancer cachexia

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background The aryl hydrocarbon receptor (AHR) is expressed in the intestine and liver, where it has pleiotropic functions and target genes. This study aims to explore the potential implication of AHR in cancer cachexia, an inflammatory and metabolic ...
Adeline Dolly, Sarah A. Pötgens, Morgane M. Thibaut, Audrey M. Neyrinck, Gabriela S. deCastro, Chloé Galbert, Camille Lefevre, Elisabeth Wyart, Silvio P. Gomes, Daniela C. Gonçalves, Nicolas Lanthier, Pamela Baldin, Joshua R. Huot, Andrea Bonetto, Marília Seelaender, Nathalie M. Delzenne, Harry Sokol, Laure B. Bindels   +17 more
doaj   +1 more source

Effects of FICZ on metabolic system in NHEK.

, 2012
A. Western blots of nuclear AhR and Arnt after 30 min exposure to 0.1 or 1.0 µM FICZ. B. Densitometry of western blot bands. C. Western blots of total whole cell AhR after 30 min exposure to 0.1 or 1.0 µM FICZ. D.
Daniela Lulli (139088), Chiara De Luca (139084), Liudmila Korkina (122497), Andrea Stancato (139081), Alla Potapovich (139075), Saveria Pastore (139092), Vladimir Kostyuk (139070)   +6 more
core   +1 more source

FICZ enhances RA-induced expression of differentiation markers and blunts the stem cell like/malignant markers.

, 2015
HL-60 cells were initiated in culture at 0.1 x 106 cells/ml with 1 μM RA, 100 nM FICZ, 1 μM α-NF and 1 μM β-NF as indicated. Induced differentiation markers were measured at 48 and 72 h by flow cytometry. The results are expressed as mean integral of the
Robert J. MacDonald (784968), Rodica P. Bunaciu (390456), Dorian H. LaTocha (784969), Andrew Yen (390458), Holly A. Jensen (390454), Jeffrey D. Varner (197251)   +5 more
core   +1 more source

Possible Roles of Proinflammatory Signaling in Keratinocytes Through Aryl Hydrocarbon Receptor Ligands for the Development of Squamous Cell Carcinoma

Frontiers in Immunology, 2020
Aryl hydrocarbon receptor (AhR) provides a deeper insight into the pathogenesis of cutaneous squamous cell carcinoma (cSCC). AhR ligands, such as 6-formylindolo[3,2-b] carbazole (FICZ), and 7,12-Dimethylbenz[a]anthracene (DMBA), constitute major ...
Yota Sato, Taku Fujimura, Takanori Hidaka, Chunbing Lyu, Kayo Tanita, Shigeto Matsushita, Masayuki Yamamoto, Setsuya Aiba   +7 more
doaj   +1 more source

Trans‐resveratrol alleviates inflammation and improves skin barrier function via aryl hydrocarbon receptor pathway in human reconstructed epidermis

International Journal of Cosmetic Science, EarlyView.
In a cytokine‐challenged human epidermal model, trans‐resveratrol reduces inflammation (IL‐1α) and oxidative stress markers (CYP1A1, CYP1B1), while modulating the expression of barrier‐related genes (LOR, OCLN) and differentiation‐associated CASP14. This supports its role as a multifunctional active for sensitive and compromised skin.
Irini M. Dijkhoff, Sandeep Keshavan, Regina G. Daré, Alke Petri‐Fink, Marc Eeman, Agnès Tessier, Barbara Rothen‐Rutishauser   +6 more
wiley   +1 more source

AHR2 as a Potential Integrator of Eco‐Evo‐Devo in Non‐Mammalian Vertebrates: A Focus on Fishes

Evolution &Development, Volume 28, Issue 4, December 2026.
AHR2 mediated signals in eco‐evo‐devo context: Left: Ontogenetic window illustrating how chemical ligands (green) interact with developmental responses (blue) through AHR2 signaling mechanisms (pink). Right: Evolutionary window illustrating how sequence and regulatory evolution of the AHR2 pathway can promote the emergence of novel phenotypes and ...
Leandro Lofeu, Christian Sturmbauer, Ehsan Pashay Ahi   +2 more
wiley   +1 more source