Results 31 to 40 of about 2,459 (190)

The Ability of AhR Ligands to Attenuate Delayed Type Hypersensitivity Reaction Is Associated With Alterations in the Gut Microbiota

Frontiers in Immunology, 2021
Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that regulates T cell function. The aim of this study was to investigate the effects of AhR ligands, 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), and 6-Formylindolo[3,2-b]carbazole
Osama A. Abdulla, Wurood Neamah, Muthanna Sultan, Hasan K. Alghetaa, Narendra Singh, Philip Brandon Busbee, Mitzi Nagarkatti, Prakash Nagarkatti   +7 more
doaj   +1 more source

6-Formylindolo[3,2-b]carbazole, a Potent Ligand for the Aryl Hydrocarbon Receptor Produced Both Endogenously and by Microorganisms, can Either Promote or Restrain Inflammatory Responses

Frontiers in Toxicology, 2022
The aryl hydrocarbon receptor (AHR) binds major physiological modifiers of the immune system. The endogenous 6-formylindolo[3,2-b]carbazole (FICZ), which binds with higher affinity than any other compound yet tested, including TCDD, plays a well ...
Agneta Rannug
doaj   +1 more source

Inhibiting SARS-CoV-2 infection in vitro by suppressing its receptor, angiotensin-converting enzyme 2, via aryl-hydrocarbon receptor signal

Scientific Reports, 2021
Since understanding molecular mechanisms of SARS-CoV-2 infection is extremely important for developing effective therapies against COVID-19, we focused on the internalization mechanism of SARS-CoV-2 via ACE2.
Keiji Tanimoto, Kiichi Hirota, Takahiro Fukazawa, Yoshiyuki Matsuo, Toshihito Nomura, Nazmul Tanuza, Nobuyuki Hirohashi, Hidemasa Bono, Takemasa Sakaguchi   +8 more
doaj   +1 more source

Rosmarinus officinalis L. Leaf Extracts and Their Metabolites Inhibit the Aryl Hydrocarbon Receptor (AhR) Activation In Vitro and in Human Keratinocytes: Potential Impact on Inflammatory Skin Diseases and Skin Cancer

Molecules, 2022
Aryl hydrocarbon receptor (AhR) activation by environmental agents and microbial metabolites is potentially implicated in a series of skin diseases. Hence, it would be very important to identify natural compounds that could inhibit the AhR activation by ...
Panagiotis Kallimanis, Ioanna Chinou, Angeliki Panagiotopoulou, Anatoly A. Soshilov, Guochun He, Michael S. Denison, Prokopios Magiatis   +6 more
doaj   +1 more source

AhR agonist Ficz modulates T follicular helper cells and ameliorates skin fibrosis in a bleomycin-induced SSc mouse model. [PDF]

J Scleroderma Relat Disord
Objectives T follicular helper (Tfh) cells are involved in the pathogenesis of systemic sclerosis (SSc). Recent investigations have revealed aryl hydrocarbon receptor (AhR) regulated skin fibrosis in SSc. This study aims to explore the effect of AhR agonist Ficz on Tfh in a bleomycin (BLM)-induced SSc mouse ...
Zhu X, Chen Y, Qiu C, Wei M, Chen J, Luo B, Qi Q.   +6 more
europepmc   +4 more sources

AhR Ligands Modulate the Differentiation of Innate Lymphoid Cells and T Helper Cell Subsets That Control the Severity of a Pulmonary Fungal Infection

Frontiers in Immunology, 2021
In agreement with other fungal infections, immunoprotection in pulmonary paracoccidioidomycosis (PCM) is mediated by Th1/Th17 cells whereas disease progression by prevalent Th2/Th9 immunity.
Eliseu F. de Araújo, Flávio V. Loures, Nycolas W. Preite, Cláudia Feriotti, Nayane AL Galdino, Tânia A. Costa, Vera L. G. Calich   +6 more
doaj   +1 more source

AhR Ligands Differentially Regulate miRNA-132 Which Targets HMGB1 and to Control the Differentiation of Tregs and Th-17 Cells During Delayed-Type Hypersensitivity Response

Frontiers in Immunology, 2021
Aryl hydrocarbon receptor (AhR), is a transcription factor and an environmental sensor that has been shown to regulate T cell differentiation. Interestingly, AhR ligands exert varying effects from suppression to exacerbation of inflammation through ...
Osama A. Abdulla, Wurood Neamah, Muthanna Sultan, Saurabh Chatterjee, Narendra Singh, Mitzi Nagarkatti, Prakash Nagarkatti   +6 more
doaj   +1 more source

The aryl hydrocarbon receptor maintains antitumor activity of liver resident natural killer cells after partial hepatectomy in C57BL/6J mice

Cancer Medicine, 2023
Background Liver‐resident natural killer (lr‐NK) cells are distinct from conventional NK cells and exhibit higher cytotoxicity against hepatoma via tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL).
Koki Sato, Masahiro Ohira, Yuki Imaoka, Kouki Imaoka, Tomoaki Bekki, Marlen Doskali, Ryosuke Nakano, Takuya Yano, Yuka Tanaka, Hideki Ohdan   +9 more
doaj   +1 more source

Effect of AhR activation on intestinal flora and short-chain fatty acid content in immune stressed piglets

Siliao yanjiu, 2023
The study aimed to investigate the effect of AhR activation on intestinal flora and short-chain fatty acid content in immune-stressed piglets. A total of 24 weaned piglets (Duroc × Landrace × Yorkshire) with good health and similar weight at 21 d were ...
WU Xiao-mei, JI Meng-yao, YANG Wen, FANG Yi, DENG Tan-jie, AN Zhao-xiang, ZHANG Ya-lei, XUN Wen-juan   +7 more
doaj  

Aryl hydrocarbon receptor signals attenuate lung fibrosis in the bleomycin-induced mouse model for pulmonary fibrosis through increase of regulatory T cells

Arthritis Research & Therapy, 2020
Background Interstitial lung disease (ILD) is a serious complication of connective tissue diseases (CTDs). Although immune dysregulation triggered by genetic and environmental factors is thought to provoke inflammation and subsequent fibrosis, precise ...
Hiroshi Takei, Hidekata Yasuoka, Keiko Yoshimoto, Tsutomu Takeuchi   +3 more
doaj   +1 more source