Roles for B[a]P and FICZ in subchondral bone metabolism and experimental temporomandibular joint osteoarthritis via the AhR/Cyp1a1 signaling axis [PDF]
Scientific Reports, 2021 Bone loss due to smoking represents a major risk factor for fractures and bone osteoporosis. Signaling through the aryl hydrocarbon receptor (AhR) and its ligands contributes to both bone homeostasis and inflammatory diseases.
Yuri Yoshikawa +6 more
doaj +7 more sources
6-Formylindolo(3,2-b)Carbazole (FICZ) Modulates the Signalsome Responsible for RA-Induced Differentiation of HL-60 Myeloblastic Leukemia Cells. [PDF]
PLoS ONE, 2015 6-Formylindolo(3,2-b)carbazole (FICZ) is a photoproduct of tryptophan and an endogenous high affinity ligand for aryl hydrocarbon receptor (AhR). It was previously reported that, in patient-derived HL-60 myeloblastic leukemia cells, retinoic acid (RA ...
Rodica P Bunaciu +5 more
doaj +5 more sources
Evidence for New Light-Independent Pathways for Generation of the Endogenous Aryl Hydrocarbon Receptor Agonist FICZ [PDF]
Chemical Research in Toxicology, 2016 Activation of the aryl hydrocarbon receptor (AhR), a conserved transcription factor best known as a target for highly toxic halogenated substances such as dioxin, under normal xenobiotic-free conditions is of considerable scientific interest.
Vikström Bergander, Linda +13 more
core +4 more sources
FICZ Exposure and Viral Infection in Mice
Bio-Protocol, 2017 The aryl hydrocarbon receptor (AHR) is known as a sensor for dioxins that mediates their toxicity, and also has important biophysiological roles such as circadian rhythms, cell differentiation and immune responses.
Taisho Yamada, Akinori Takaoka
doaj +4 more sources
How the AHR Became Important in Intestinal Homeostasis—A Diurnal FICZ/AHR/CYP1A1 Feedback Controls Both Immunity and Immunopathology [PDF]
International Journal of Molecular Sciences, 2020 Ever since the 1970s, when profound immunosuppression caused by exogenous dioxin-like compounds was first observed, the involvement of the aryl hydrocarbon receptor (AHR) in immunomodulation has been the focus of considerable research interest.
Agneta Rannug, Rannug, A,
core +3 more sources
Scientific Reports, 2017 Potentially mutagenic DNA lesions induced by UVB (wavelengths 280–320 nm) are important risk factors for solar ultraviolet (UV) radiation-induced skin cancer.
Reto Brem +3 more
doaj +2 more sources
Light-dependent decomposition of FICZ, an endogenous ligand of the aryl hydrocarbon receptor [PDF]
, 2017 An efficient and scalable synthesis of 6-formylindolo[3,2-b]carbazole (FICZ) has been developed to provide large quantities of this physiologically important ligand of the aryl hydrocarbon receptor.
Katrina L. Creech +3 more
core +2 more sources
Ficz Emma kisebbségpolitikus, művelődésszervező, kormányfőtanácsos
, 2020 Ficz Emma, 44 éves, két diplomával rendelkező kormánytisztviselő, aki jelenleg a Belügyminisztérium munkatársa. Mezőpeterden, romungro család gyermekeként nőtt fel, számos romákhoz kapcsolódó projekten, kulturális programon dolgozott tervezőként ...
Lívia Renáta Járóka, Emma Ficz
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Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl hydrocarbon receptor [PDF]
Proceedings of the National Academy of Sciences, 2012 Altered systemic levels of 6-formylindolo[3,2-b]carbazole (FICZ), an enigmatic endogenous ligand for the aryl hydrocarbon receptor (AHR), may explain adverse physiological responses evoked by small natural and anthropogenic molecules as well as by ...
Bengtsson, J +13 more
core +3 more sources
TCDD, FICZ, and Other High Affinity AhR Ligands Dose-Dependently Determine the Fate of CD4+ T Cell Differentiation [PDF]
Toxicological Sciences, 2017 FICZ and TCDD, two high-affinity AhR ligands, are reported to have opposite effects on T cell differentiation with TCDD inducing regulatory T cells and FICZ inducing Th17 cells.
Jamie M Pennington +9 more
core +6 more sources