Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner [PDF]
Biochemical Pharmacology, 2016 6-Formylindolo[3,2-b]carbazole (FICZ) is a potent aryl hydrocarbon receptor (AHR) agonist that is efficiently metabolized by AHR-regulated cytochrome P4501 enzymes. FICZ is a proposed physiological AHR ligand that induces its own degradation as part of a
Hahn, ME +20 more
core +5 more sources
Induction of long interspersed nucleotide element-1 (L1) retrotransposition by 6-formylindolo[3,2- b ]carbazole (FICZ), a tryptophan photoproduct [PDF]
Proceedings of the National Academy of Sciences, 2010 Long interspersed nucleotide element-1 (L1) is a retroelement comprising about 17% of the human genome, of which 80–100 copies are competent as mobile elements (retrotransposition: L1-RTP).
Takayoshi Koyama +6 more
core +3 more sources
6-Formylindolo[3,2-b]carbazole (FICZ) is a Very Minor Photoproduct of Tryptophan at Biologically Relevant Doses of UVB and Simulated Sunlight [PDF]
Photochemistry and Photobiology, 2018 International audienceExposure to solar UV is at the origin of numerous photodegradation pathways in biomolecules. Tryptophan is readily modified by UVB radiation into ring-opened and oxidized photoproducts.
Sylvain Caillat +11 more
core +5 more sources
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2016 The tryptophan derivative formylindolo[3,2-b]carbazole (FICZ) binds with high ligand affinity to the aryl hydrocarbon receptor (AHR) and is readily degraded by AHR-regulated cytochrome P450 family 1 (CYP1) enzymes.
Mattsson, Anna, +3 more
core +3 more sources
Inhibition of CYP1A1 by pharmaceutical drugs, omeprazol and ketoconazole as a mechanism for activation of aryl hydrocarbon receptor (AHR) [PDF]
Trends in Pharmaceutical Sciences, 2017 Omeprazole (OMP) and ketoconazole (KTZ) have been shown to activate the AHR signaling pathway in spite of the fact that they bind to the receptor with low or no affinity.
Ali Ghaffarian-Bahraman +8 more
doaj +3 more sources
FICZ: A Messenger of Light in Human Skin [PDF]
Journal of Investigative Dermatology, 2015 Photosensitization, subsequent to photon absorption by chromophores present in the human skin, appears to be a key mechanism of UV-induced oxidative stress. The tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ), an aryl hydrocarbon receptor ligand, has been found to be a potent UVA photosensitizer, effective at nanomolar concentrations.
Syed, Deeba N., Mukhtar, Hasan
openaire +2 more sources
6-Formylindolo[3,2-B]Carbazole (FICZ) Enhances The Expression Of Tumor Suppressor MiRNAs, MiR-22, MiR-515-5p, And MiR-124-3p In MCF-7 Cells [PDF]
Cell Journal, 2020 Objective microRNAs (miRNAs) play bifunctional roles in the initiation and progression of cancer, and recent evidence has confirmed that unusual expression of miRNAs is required for the progress of breast cancer.
Keivan Mobini +3 more
doaj +1 more source
Gram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor [PDF]
Scientific Reports, 2019 AbstractDevelopment of an efficient and scalable synthesis of 6-formylindolo[3,2-b]carbazole (FICZ), a naturally-occurring aryl hydrocarbon receptor (AhR) ligand, allowed its biological and physical properties to be studied. FICZ was shown to be the most potent among a series of 6-substituted indolo[3,2-b]carbazoles for activation of AhR in cells ...
Cunyu Zhang +3 more
openaire +2 more sources
陆军军医大学学报, 2023 Objective To investigate the protective effects of aryl hydrocarbon receptor (AhR) activation of 6-formylindolo [3, 2-B] carbazole (FICZ) on intestinal barrier damage and its potential mechanism in a mouse model of total parenteral nutrition (TPN ...
LIU Xingyu +5 more
doaj +1 more source
RSC Advances, 2022 FICZ/AhR axis might be a potential target to achieve optimal bone regeneration for both BMSCs and primed cartilage templates.
Jing Huang, Yining Wang, Yi Zhou
openaire +2 more sources