Indole compounds produced by gut microbiota after metabolizing tryptophan improve dysmotility in sepsis via the AHR-TRPA1 axis in enteric nerves [PDF]
BMC MicrobiologyBackground Sepsis represents a major global health challenge, and the resulting impaired intestinal motility can lead to numerous adverse outcomes. Indole compounds produced by gut microbiota after metabolizing tryptophan may improve sepsis-induced ...
Jintao Zhang +7 more
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Future Journal of Pharmaceutical SciencesThe aryl hydrocarbon receptor (AHR) ligand, 6-formylindolo[3,2-b]carbazole (FICZ), plays a pivotal role in modulating various biological processes, including circadian rhythms and maintenance of cellular homeostasis.
Fatemeh Ahmadi +1 more
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Cooperation or Conflict? Molecular and Physiological Cross-Talk Between the Aryl Hydrocarbon and Vitamin D Receptors [PDF]
PharmaceuticalsThe aryl hydrocarbon receptor (AHR) and the vitamin D receptor (VDR) were long regarded as independent transcription factors governing distinct physiology—xenobiotic sensing and calcium–vitamin D homeostasis, respectively.
Mohammed A. Alqahtani
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AhR deficiency exacerbates inflammation in diabetic wounds via impaired mitophagy and cGAS-STING-NLRP3 activation: Therapeutic potential of hydrogels loaded with FICZ [PDF]
Materials Today BioDelayed healing of diabetic foot ulcers (DFUs) is driven by chronic inflammation and mitochondrial dysfunction. We identify the aryl hydrocarbon receptor (AhR) as a key regulator of immune and mitochondrial homeostasis in diabetic wounds.
Yingying Wang +12 more
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Aryl hydrocarbon receptor-mediated transcriptional regulation of HSP70 exacerbates endoplasmic reticulum stress in lupus nephritis [PDF]
Cell & BioscienceLupus nephritis (LN) is a severe and prevalent complication of systemic lupus erythematosus (SLE), often leading to progressive kidney damage. Endoplasmic reticulum (ER) stress, arising from proteostatic imbalance, triggers the unfolded protein response (
Min Wen +13 more
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Synthesis and Evaluation of the AhR Activity of Indolo[3,2-b]carbazole Derivatives [PDF]
MoleculesThe Aryl-hydrocarbon Receptor (AhR) is implicated in the regulation of several genes, including those encoding CYP1A1. Although it is an orphan receptor, the amount of data about its relationship with skin homeostasis and nosology is constantly ...
Nikitia Mexia +2 more
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Correlation of AHR Activation-Induced Suppression of PWM-Stimulated IgG and IgG-Triggered Signaling in Human PBMCs [PDF]
AntibodiesBackground/Objectives: Aryl hydrocarbon receptor (AHR) ligands are known to suppress antibody production. However, it remains unclear whether this suppression translates into altered antibody-mediated Fcγ receptor signaling in human cells.
Arpita Deb, Barbara L. F. Kaplan
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CellsAlthough our skin is not the primary visual organ in humans, it acts as a light sensor, playing a significant role in maintaining our health and overall well-being.
Tiziana Guarnieri
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Activation of the aryl hydrocarbon receptor with structurally diverse ligands suppresses class switch to immunoglobulin A [PDF]
BMC Research NotesObjective Activation of the aryl hydrocarbon receptor (AhR) with its prototypical agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suppresses B cell class switch recombination (CSR).
Alex B. Costa, Gregory K. DeKrey
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Redox Biology, 2021 Ultraviolet (UV) B irradiation of keratinocytes results in the formation of the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) which is a high-affinity ligand for the aryl hydrocarbon receptor (AHR).
Katharina M. Rolfes +11 more
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