Results 71 to 80 of about 5,812 (161)

Mucosal immunization with filamentous hemagglutinin protects against Bordetella pertussis respiratory infection [PDF]

Infection and Immunity, 1992
Mucosal immunization of mice with purified Bordetella pertussis filamentous hemagglutinin (FHA), by either the respiratory or the gut route, was found to protect against B. pertussis infection of the trachea and lungs. Intranasal immunization of BALB/c and (C57BL/6 x C3H/HeN)F1 adult female mice with FHA prior to B. pertussis aerosol challenge resulted
R D, Shahin, D F, Amsbaugh, M F, Leef
openaire   +2 more sources

Effect of FHA and Prn on Bordetella pertussis colonization of mice is dependent on vaccine type and anatomical site.

PLoS ONE, 2020
Bordetella pertussis vaccine escape mutants that lack expression of the pertussis antigen pertactin (Prn) have emerged in vaccinated populations in the last 10-20 years.
Anne Zeddeman, Evi van Schuppen, Kristianne E Kok, Marjolein van Gent, Kees J Heuvelman, Marieke J Bart, Han G J van der Heide, Joshua Gillard, Elles Simonetti, Marc J Eleveld, Fred J H van Opzeeland, Saskia van Selm, Ronald de Groot, Marien I de Jonge, Frits R Mooi, Dimitri A Diavatopoulos   +15 more
doaj   +1 more source

Serum proteases prevent bacterial biofilm formation: role of kallikrein and plasmin

Virulence, 2021
Biofilm formation is a general strategy for bacterial pathogens to withstand host defense mechanisms. In this study, we found that serum proteases inhibit biofilm formation by Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus influenzae, and ...
Jesús Arenas, Zalan Szabo, Jelle van der Wal, Coen Maas, Tahira Riaz, Tone Tønjum, Jan Tommassen   +6 more
doaj   +1 more source

Active Vaccination Strategies for Alzheimer's Disease: An Expanded Review

European Journal of Immunology, Volume 56, Issue 8, August 2026.
Overview of immunotherapeutic strategies targeting Alzheimer's disease (AD) pathology and their clinical implications. (Left) Key neuropathological hallmarks of AD, including extracellular amyloid‐beta (Aβ) aggregates and intraneuronal hyperphosphorylated Tau (phospho‐Tau), converge to produce synaptic failure, neuroinflammation and neuronal ...
Antonella Comitato, Antonino Neri, Andrea Cossarizza   +2 more
wiley   +1 more source

Range‐Wide Genetic Population Structure and Environmental Adaptation in the Eastern Oyster (Crassostrea virginica) Provides Insight for Aquaculture

Molecular Ecology, Volume 35, Issue 15, August 2026.
ABSTRACT Selective breeding in aquaculture is necessary to establish food security and meet demand for sustainably produced protein. An informed selective breeding program requires understanding how population structure, environmental adaptation, and human activities shape natural genetic variation in wild conspecifics.
Madeline G. Eppley, Kiran Bajaj, Camille Rumberger, Elisabeth Leung, Nicole Mongillo, Jessica Small, Katie E. Lotterhos   +6 more
wiley   +1 more source

Immunodominant Domains Present on theBordetella pertussisVaccine Component Filamentous Hemagglutinin [PDF]

The Journal of Infectious Diseases, 1997
To identify immunologically important domains on filamentous hemagglutinin (FHA), a Bordetella pertussis protein included in new acellular pertussis vaccines (ACPVs), a series of monoclonal antibodies, sera from infants vaccinated with ACPVs or whole cell pertussis vaccine (WCPV), and sera from patients with pertussis were analyzed by immunoblots ...
E, Leininger, S, Bowen, G, Renauld-Mongénie, J H, Rouse, F D, Menozzi, C, Locht, I, Heron, M J, Brennan   +7 more
openaire   +2 more sources

To Move or Not to Move: When and How Bacteria Suppress Flagellar Motility

Molecular Microbiology, Volume 126, Issue 2, Page 173-189, August 2026.
Motility cessation in bacteria is a key regulatory strategy that provides multiple survival advantages including enhanced community cooperation, niche adaptation and evasion of host immune responses. This process is controlled by associated mechanisms such as post‐translational modifications and second messenger signalling that stabilise non‐motile ...
Fatemeh Mohaghegh, Jacob Scadden, Matthew A. B. Baker   +2 more
wiley   +1 more source

Bordetella pertussis binds the human complement regulator C4BP: role of filamentous hemagglutinin [PDF]

Infection and Immunity, 1997
C4BP (C4b-binding protein) is a high-molecular-weight plasma protein that inhibits the classical pathway of complement activation. Recent experiments have demonstrated that C4BP binds to many strains of the gram-positive bacterium Streptococcus pyogenes, a major respiratory tract pathogen. Binding to S.
Berggard, K, Johnsson, E, Mooi, FR, Lindahl, G   +3 more
openaire   +3 more sources

Safety and immunogenicity of an indigenously developed tetanus toxoid, diphtheria toxoid, and acellular pertussis vaccine (Tdap) in adults, adolescents, and children in India

Expert Review of Vaccines, 2023
Background This study assessed safety and immunogenicity of Serum Institute of India Pvt Ltd (SIIPL)’s tetanus toxoid (TT), diphtheria toxoid (DT), and acellular pertussis booster vaccine (Tdap).
Hitt J Sharma, Sameer Parekh, Pramod Pujari, Sunil Shewale, Shivani Desai, Anand Kawade, Mandyam Ravi, Jitendra Oswal, Saji James, N. Mahantashetti, Renuka Munshi, Apurba Ghosh, Venkateshwar Rao, Sundaram Balsubramaniam, P. Varughese, A. Somshekhar, Amy Sarah Ginsburg, Harish Rao, Manish Gautam, Sunil Gairola, Umesh Shaligram   +20 more
doaj   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, Volume 13, Issue 41, 22 July 2026.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source