Results 51 to 60 of about 5,542 (153)

Multiplex Point-of-Care Tests for the Determination of Antibodies after Acellular Pertussis Vaccination

Diagnostics, 2020
Most of the current serological diagnosis of pertussis is based on pertussis toxin (PT) IgG antibodies and does not differentiate between vaccination and infection-induced antibodies. PT is included in all of acellular pertussis vaccines available in the
Aapo Knuutila, Carita Rautanen, Jussi Mertsola, Qiushui He   +3 more
doaj   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

Filamentous Hemagglutinin ofBordetella bronchisepticaIs Required for Efficient Establishment of Tracheal Colonization [PDF]

Infection and Immunity, 1998
ABSTRACTAdherence to ciliated respiratory epithelial cells is considered a critical early step inBordetellapathogenesis. ForBordetella pertussis, the etiologic agent of whooping cough, several factors have been shown to mediate adherence to cells and cell lines in vitro.
Cotter, Peggy A., Yuk, Ming H., Mattoo, Seema, Akerley, Brian J., Boschwitz, Jeff, Relman, David A., Miller, Jeff F.   +6 more
openaire   +3 more sources

The Highly Productive Thermothelomyces heterothallica C1 Expression System as a Host for Rapid Development of Influenza Vaccines

Vaccines, 2022
(1) Influenza viruses constantly change and evade prior immune responses, forcing seasonal re-vaccinations with updated vaccines. Current FDA-approved vaccine manufacturing technologies are too slow and/or expensive to quickly adapt to mid-season changes
Gabor Keresztes, Mark Baer, Mark R. Alfenito, Theo C. Verwoerd, Andriy Kovalchuk, Marilyn G. Wiebe, Tor Kristian Andersen, Markku Saloheimo, Ronen Tchelet, Richard Kensinger, Gunnveig Grødeland, Mark Emalfarb   +11 more
doaj   +1 more source

The power of many: when genetics met yeasts and high‐throughput

Biological Reviews, EarlyView.
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley   +1 more source

A novel method for the extraction of outer membrane vesicles (OMVs) from Bordetella pertussis Tohama strain

Iranian Journal of Microbiology, 2020
Background and Objectives: There are many pertussis outbreaks which is mainly due to the reduction in the immunity of acellular pertussis (aP) vaccines. Therefore, there is a crucial necessity to develop a new generation of pertussis vaccine.
Mohammad Sekhavati, Ashraf Mohabati Mobarez, Seyed Davar Siadat, Mojtaba Noofeli   +3 more
doaj   +1 more source

Antibodies to Bordetella pertussis antigens in maternal and cord blood pairs: a Thai cohort study [PDF]

PeerJ, 2017
Background Pertussis is a vaccine-preventable disease, yet an increasing incidence of pertussis occurs in many countries. Thailand has a long-standing pertussis vaccination policy, therefore most expectant mothers today had received vaccines as children.
Nasamon Wanlapakorn, Thanunrat Thongmee, Preeyaporn Vichaiwattana, Elke Leuridan, Sompong Vongpunsawad, Yong Poovorawan   +5 more
doaj   +2 more sources

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Expression of adhesins by some “Bordetella pertussis” strains isolated in Romania in different time periods

Studia Universitatis Babeș-Bolyai. Biologia, 2018
Bordetella pertussis is the etiological agent of whooping cough or pertussis, a respiratory infection in humans which can be prevented by vaccination. B.
Georgeta Cristina OPREA, Veronica LAZĂR
doaj   +1 more source